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Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis.

Abstract：

:In a prospective study, we analysed the presence of monoclonal immunoglobulin (moIg) in the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS group and 13.3% in the control group. Most ALS sera contained 2 or 3 monoclonal components. They were IgG (72.7%) and IgM (27.3%). These results corroborate the concept of a probable association between ALS and serum moIg.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Duarte F,Binet S,Lacomblez L,Bouche P,Preud'homme JL,Meininger V

doi

10.1016/0022-510x(91)90220-2

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

88-91

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(91)90220-2

journal_volume

104

pub_type

杂志文章

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