当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Seasonal variations of 25-OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients.

Seasonal variations of 25-OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients.

Abstract：

:Low 25-hydroxy vitamin D (25-[OH]-D) serum concentrations have been associated with higher disease activity in multiple sclerosis (MS) patients. In a large cross-sectional study we assessed the vitamin D status in MS patients in relation to seasonality and relapse rate. 415 MS-patients (355 relapsing-remitting MS and 60 secondary-progressive, 282 female, mean age 39.1years) of whom 25-(OH)-D serum concentrations were determined at visits between 2010 and 2013 were included in the study. All clinical data including relapse at visit and expanded disability status scale were recorded in a standardized manner by an experienced neurologist. Seasonal variations of 25-(OH)-D serum concentrations were modelled by sinusoidal regression and seasonal variability in the prevalence of relapse by cubic regression. The mean 25-(OH)-D serum concentration was 24.8ng/ml (range 8.3-140ng/ml) with peak levels of 32.2ng/ml in July/August and nadir in January/February (17.2ng/ml). The lowest modelled prevalence of relapse was in September/October (28%) and the highest modelled prevalence in March/April (47%). The nadir of 25-(OH)-D serum concentrations preceded the peak in prevalence of relapses by two months. In summary, seasonal variation of 25-(OH)-D serum levels were inversely associated with clinical disease activity in MS patients. Future studies should investigate whether vitamin D supplementation in MS patients may decrease the seasonal risk for MS relapses.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Hartl C,Obermeier V,Gerdes LA,Brügel M,von Kries R,Kümpfel T

doi

10.1016/j.jns.2017.01.059

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

160-164

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(17)30068-0

journal_volume

375

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy.

    abstract：:Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disorder of muscle in children. The DMD gene product, "dystrophin", is absent from DMD, while the allelic disease, Becker muscular dystrophy (BMD), exhibits dystrophin of abnormal size and/or quantity. But we are still uncertain about the scenario that in...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90039-a

    authors： Arahata K,Beggs AH,Honda H,Ito S,Ishiura S,Tsukahara T,Ishiguro T,Eguchi C,Orimo S,Arikawa E

    更新日期：1991-02-01 00:00:00

  • Hemorheologic profiles of plasma fibrinogen and blood viscosity from silent to acute and chronic cerebral infarctions.

    abstract：:Hemorheologic changes from silent to acute and chronic cerebral infarction have seldom been reported. We evaluated hemorheologic profiles of the whole blood viscosity, plasma viscosity and fibrinogen level in stroke at-risk patients with silent cerebral infarction, patients with acute or chronic cerebral lacunar infar...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(96)05309-9

    authors： Tsuda Y,Satoh K,Kitadai M,Takahashi T

    更新日期：1997-03-20 00:00:00

  • Neurophysiological evidence for long-term repair of MS lesions: implications for axon protection.

    abstract：:After recovery from the acute stage of optic neuritis, a marked prolongation in the latencies of visual evoked potentials (VEPs) is typically observed. We have conducted three studies (one cross-sectional, two prospective), aimed at elucidating the progressive shortening of VEP latency, which frequently ensues over th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00428-8

    authors： Jones SJ,Brusa A

    更新日期：2003-02-15 00:00:00

  • Maintenance IVIg therapy in myasthenia gravis does not affect disease activity.

    abstract：OBJECTIVES:There is insufficient data on the efficacy of intravenous immunoglobulins (IVIg) as maintenance treatment in myasthenia gravis (MG). We therefore examined response to maintenance IVIg therapy in a cohort of MG patients. METHODS:We reviewed all MG patient files treated with IVIg in our neuro-immunology clini...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.10.043

    authors： Hellmann MA,Mosberg-Galili R,Lotan I,Steiner I

    更新日期：2014-03-15 00:00:00

  • Autosomal recessive distal muscular dystrophy: normal expression of dystrophin, utrophin and dystrophin-associated proteins in muscle fibers.

    abstract：:We examined 19 muscle biopsies from 14 patients with autosomal recessive distal muscular dystrophy (DisMD) histochemically and immunohistochemically to characterize the histologic features of this disease and to determine whether dystrophin and dystrophin-associated proteins (DAPs) are normally present in the muscles ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90096-5

    authors： Yamanouchi Y,Ozawa E,Nonaka I

    更新日期：1994-10-01 00:00:00

  • Early (1 h) administration of tissue plasminogen activator reduces infarct volume without increasing hemorrhagic transformation after focal cerebral embolization in rats.

    abstract：:We assessed the incidence of hemorrhagic transformation and infarct volume after early intravenous infusion of recombinant human tissue plasminogen activator (rht-PA) in a newly developed rat cerebral embolic model. Male Wistar rats (n=60) were subjected to middle cerebral artery (MCA) occlusion by a single fibrin ric...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00155-5

    authors： Zhang RL,Chopp M,Zhang ZG,Divine G

    更新日期：1998-09-18 00:00:00

  • Late onset cerebello-pontomesencephalic degeneration.

    abstract：:Two siblings are presented with late onset, rapidly progressive truncal ataxia, paralysis of down-gaze and loss of up-gaze saccades in association with other oculomotor dysfunctions as well as dementia. Electron microscopic muscle studies revealed abnormal distribution and form of the mitochondria, probably being the ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90202-5

    authors： al-Din AS,al-Zuhair AG,al-Salem MK,al-Nassar KE,Rudwan MA,Khafaja S,Hamawi T

    更新日期：1989-11-01 00:00:00

  • Diminished emotional sweating in patients with limbic encephalitis.

    abstract：OBJECTIVE:Sweating on the palms of the hands and soles of the feet, so-called emotional sweating, is considered to be mediated by the limbic system, including the amygdala and anterior cingulate cortex. To reveal involvement of the limbic system in emotional sweating, we evaluated emotional sweating on the palms in pat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.04.007

    authors： Asahina M,Fujinuma Y,Yamanaka Y,Fukushima T,Katagiri A,Ito S,Kuwabara S

    更新日期：2011-07-15 00:00:00

  • Acute canine idiopathic polyneuropathy. A Guillain-Barré-like syndrome in dogs.

    abstract：:We evaluated 14 previously healthy dogs with acute progressive flaccid quadriparesis and hyporeflexia. Electrophysiological and pathological features indicated varying degrees of motor-sensory polyneuropathy with some demyelination. Perivenular cellular infiltrations were present in roots of one autopsied case. Recove...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(82)90147-2

    authors： Northington JW,Brown MJ

    更新日期：1982-11-01 00:00:00

  • Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis.

    abstract：:The present study tested aspects of a novel etiological/pathogenetic hypothesis of Alzheimer's disease (AD), which proposes that alterations in endocrine regulation of peripheral calcium/phosphate (Ca/PO4) homeostasis (e.g., by glucocorticoids, vitamin D, etc.) induce and/or reflect altered calcium homeostasis and neu...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90261-5

    authors： Landfield PW,Applegate MD,Schmitzer-Osborne SE,Naylor CE

    更新日期：1991-12-01 00:00:00

  • Intracerebral hemorrhage and postpartum cerebral vasculopathy.

    abstract：INTRODUCTION:Intracerebral hemorrhage (ICH) associated with pregnancy commonly occurs in the postpartum period in the setting of preeclampsia/eclampsia. We describe the clinical course of two patients with ICH due to postpartum cerebral vasculopathy in the absence of toxemia. METHODS:We reviewed two cases with ICH and...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(02)00245-9

    authors： Geocadin RG,Razumovsky AY,Wityk RJ,Bhardwaj A,Ulatowski JA

    更新日期：2002-12-15 00:00:00

  • Brain MRI findings in patients with Fabry disease.

    abstract：BACKGROUND:To evaluate the presence of ischemic and hemorrhagic lesions in brain MRI of patients with Fabry disease (FD). METHODS:Brain MRI studies in 46 consecutive patients were evaluated using classic sequences as well as GRE-weighted images, for ischemic lesions and chronic microbleed detection. Of the 36 adult pa...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.03.020

    authors： Reisin RC,Romero C,Marchesoni C,Nápoli G,Kisinovsky I,Cáceres G,Sevlever G

    更新日期：2011-06-15 00:00:00

  • Canine X-linked muscular dystrophy. An animal model of Duchenne muscular dystrophy: clinical studies.

    abstract：:The progression of clinical disease and serum creatine kinase (CK) levels in canine X-linked muscular dystrophy (CXMD) was studied in 7 dogs from birth to 12-14 months and in 18 dogs at varying intervals from birth to 8 weeks. One affected male was studied from age 3.5 to 6 years, and all pups were descendants of this...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90206-7

    authors： Valentine BA,Cooper BJ,de Lahunta A,O'Quinn R,Blue JT

    更新日期：1988-12-01 00:00:00

  • Hypnic headache in childhood: A literature review.

    abstract：:Hypnic headache (HH) is a rare benign disorder described initially by Raskin in 1988. It is characterized by recurrent nocturnal episodes of headache that periodically awaken the sleeping patient and usually occur in the elderly. This review is aimed at describing the clinical features of the HH cases in childhood tha...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2015.06.048

    authors： Silva-Néto RP,Almeida KJ

    更新日期：2015-09-15 00:00:00

  • Bone marrow in the Batten-Vogt syndrome.

    abstract：:Six children with clinical and pathological features of Batten-Vogt syndrome showed autofluorescent material in bone marrow cells and in 5 of them sea-blue histiocytes were seen. It is suggested that bone marrow examination for sea-blue histiocytes and autofluorescenceis a useful screening test for ceroid-lipofuscinos...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(75)90140-9

    authors： Gadoth N,O'Croinin P,Butler IJ

    更新日期：1975-06-01 00:00:00

  • Characterization of the mitochondrial DNA in patients with multiple sclerosis.

    abstract：:Mitochondrial DNA (mtDNA) abnormalities with primary pathogenic significance for optic nerve atrophy have been detected in inflammatory demyelinating conditions indistinguishable from multiple sclerosis (MS). However, the degree of involvement of mtDNA alterations in the pathogenesis of MS is not clear. To further cla...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(96)00112-8

    authors： Kalman B,Lublin FD,Alder H

    更新日期：1996-09-01 00:00:00

  • Chronic progressive spinobulbar spasticity with disturbance of voluntary eyelid closure. Report of a case with special reference to MRI and electrophysiological findings.

    abstract：:We describe a 56-year-old man who had a progressive pseudobulbar palsy, spastic tetraparesis, forced laughing and disturbance of voluntary eyelid closure, and was clinically compatible with chronic progressive spinobulbar spasticity. Magnetic resonance images (MRI) revealed atrophy of the bilateral motor cortices and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90131-6

    authors： Nishimura M,Tojima M,Suga M,Hirose K,Tanabe H

    更新日期：1990-05-01 00:00:00

  • Brains of apolipoprotein E deficient mice fed vitamin E deficient diets show alteration in handling alpha tocopherol injected into the cerebral ventricles.

    abstract：:Abnormal function of apolipoprotein E (apoE) has been implicated in the incidence of some neurological disorders including dementia. Our recent experiments have shown that apoE deficiency alters the dynamics of alpha tocopherol (vitamin E) handling by brain. In the current investigation, we examined the uptake and ret...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.02.350

    authors： Vatassery GT,Smith WE,Quach HT

    更新日期：2009-08-15 00:00:00

  • Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study.

    abstract：:To elucidate the neuronal mechanism of the motor disturbances of the Rolling mouse Nagoya (rolling, genotype rol/rol), an experimental neurologic mutant mouse, we studied the physiological characteristics of neurons of the globus pallidus (GP) in rolling, comparing them with those of the behaviorally normal heterozygo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90139-c

    authors： Tomoda H,Kato M,Sakata S,Shima F

    更新日期：1992-10-01 00:00:00

  • The spinal cord in lightning injury: a report of two cases.

    abstract：:We present 2 patients in whom the predominant neurological complication following lightning strike was spinal cord injury. One patient, who was followed for 5 years, showed clinical, electrophysiologic and MRI evidence of cervical spinal cord injury. This patient had significant recovery, which in part, may be related...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.09.020

    authors： Lakshminarayanan S,Chokroverty S,Eshkar N,Grewal R

    更新日期：2009-01-15 00:00:00

  • Microheterogeneity of anti-myelin-associated glycoprotein antibodies.

    abstract：:Antibodies to the myelin-associated glycoprotein (MAG) are implicated in the pathogenesis of an acquired demyelinating polyneuropathy. We studied IgM affinity to MAG in 18 patients with anti-MAG antibodies. Binding of sera was tested for anti-MAG immunoreactivity in central nervous system (CNS) by ELISA and in CNS and...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00359-3

    authors： Fluri F,Ferracin F,Erne B,Steck AJ

    更新日期：2003-03-15 00:00:00

  • Restoration of brain growth in fetal sheep after iodized oil administration to pregnant iodine-deficient ewes.

    abstract：:Iodized oil was administered as a single intramuscular injection to pregnant iodine-deficient ewes at 100 days gestation and the subsequent growth of their fetuses compared with that of fetuses of severely iodine-deficient ewes and of iodine-replete ewes, all of which were fed the same low-iodine diet. The administere...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90137-0

    authors： Potter BJ,Mano MT,Belling GB,Martin DM,Cragg BG,Chavadej J,Hetzel BS

    更新日期：1984-10-01 00:00:00

  • Voices behind the left shoulder: two patients with right-sided temporal lobe epilepsy.

    abstract：:Auditory vocal hallucinations are sometimes observed in temporal-lobe epilepsy, but are a frequent sign of psychosis and may rarely be mistaken for the latter. Here we report two patients who suffered from auditory vocal hallucinations, described as unintelligible human voices perceived at their left side during epile...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.03.029

    authors： Hug A,Bartsch A,Gutschalk A

    更新日期：2011-06-15 00:00:00

  • A census of movement disorders at a Thai university hospital.

    abstract：:There is little information available on the number of patients with movement disorders seen by physicians in Thailand. The authors reviewed the medical records of all movement disorders patients seen at the Chulalongkorn Comprehensive Movement Disorders Center (CUMDS) in Bangkok, Thailand over a 4.5-year period to de...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.11.010

    authors： Bhidayasiri R,Saksornchai K,Kaewwilai L,Phanthumchinda K

    更新日期：2011-02-15 00:00:00

  • Post-streptococcal 'complex' movement disorders: unusual concurrence of psychogenic and organic symptoms.

    abstract：:Post-streptococcal neuropsychiatric disorders encompass a broad spectrum of movement disorders, including tics, stereotypies, dystonia and tremor. We report the case of a 15-year-old boy who presented with a relapsing-remitting combination of psychogenic and organic movement disorders. Both relapses occurred after an ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.10.004

    authors： Squintani G,Tinazzi M,Gambarin M,Bravi E,Moretto G,Buttiglione M,Defazio G,Martino D

    更新日期：2010-01-15 00:00:00

  • Cerebrospinal fluid autoantibodies to myelin basic protein in multiple sclerosis patients. Detection during first exacerbations and kinetics of acute relapses and subsequent convalescent phases.

    abstract：:In order to determine if free (F) and bound (B) levels of autoantibodies to myelin basic protein (anti-MBP) are present from the onset of multiple sclerosis (MS), 201 patients referred to our clinic were clinically divided into a group diagnosed as having an initial MS relapse and a group of non-MS controls. Ninety-fo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90083-x

    authors： Warren KG,Catz I

    更新日期：1989-06-01 00:00:00

  • White matter lesions and depression in patients with Parkinson's disease.

    abstract：:Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investig...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.07.021

    authors： Petrovic IN,Stefanova E,Kozic D,Semnic R,Markovic V,Daragasevic NT,Kostic VS

    更新日期：2012-11-15 00:00:00

  • Virus antibodies in the cerebrospinal fluid of multiple sclerosis patients detected with ELISA tests.

    abstract：:The enzyme-linked immunosorbent assay (ELISA) was used to determine levels of specific IgG antibodies against measles, rubella, vaccinia, corona (OC43) and mumps viruses in cerebrospinal fluid (CSF) and serum of 18 patients with clinically definite multiple sclerosis (MS), 8 patients with optic neuritis (ON), 27 patie...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(82)90031-4

    authors： Leinikki P,Shekarchi I,Iivanainen M,Taskinen E,Holmes KV,Madden D,Sever JL

    更新日期：1982-12-01 00:00:00

  • Apolipoprotein E polymorphisms status in Iranian patients with multiple sclerosis.

    abstract：BACKGROUND:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system. Evidences linking apolipoprotein E (APOE) to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggest that it may be relevant in MS. The main goal of this study was to determine whet...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.05.050

    authors： Rafiei M,Zarif Yeganeh M,Sheikholeslami S,Gozalpour E,Ghaffarpour M,Hedayati M

    更新日期：2012-09-15 00:00:00

  • Motor neuron disease in the province of Turin, Italy, 1966-1980. Survival analysis in an unselected population.

    abstract：:We performed a population based survival analysis of all incident cases (220) of motor neuron disease (MND) in the province of Turin, Italy, during the period 1966-1980. 175 cases were diagnosed as amyotrophic lateral sclerosis (ALS), 43 as progressive muscular atrophy (PMA) and 2 as progressive bulbar palsy (PBP). Th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90004-2

    authors： Mortara P,Chiò A,Rosso MG,Leone M,Schiffer D

    更新日期：1984-11-01 00:00:00