Abstract:
:We examined 19 muscle biopsies from 14 patients with autosomal recessive distal muscular dystrophy (DisMD) histochemically and immunohistochemically to characterize the histologic features of this disease and to determine whether dystrophin and dystrophin-associated proteins (DAPs) are normally present in the muscles of patients with this disorder. The common histologic features in DisMD were active muscle fiber necrosis and regeneration with variation in fiber size, predominantly in the gastrocnemius muscle. There were occasional disorganizations of the intermyofibrillar network such as moth-eaten appearance, lobulated, whorled and targetoid fibers. In one half of the patients, small angular fibers and scattered rimmed vacuoles were also found. On immunohistochemical examination, dystrophin, DAPs, spectrin and laminin were normally expressed along the surface membrane of muscle fibers, even in the advanced stages of the disease. In contrast, dystrophin was absent and DAPs reduced in the sarcolemma of Duchenne muscular dystrophy (DMD) muscles. The overall histochemical features in DisMD were similar to those seen in DMD, though dystrophin and DAPs were normally expressed even in severely affected gastrocnemius muscle. A defect in an as yet unidentified protein rather than in DAPs and dystrophin is probably responsible for the muscle fiber necrosis in DisMD.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Yamanouchi Y,Ozawa E,Nonaka Idoi
10.1016/0022-510x(94)90096-5subject
Has Abstractpub_date
1994-10-01 00:00:00pages
70-6issue
1eissn
0022-510Xissn
1878-5883pii
0022-510X(94)90096-5journal_volume
126pub_type
杂志文章abstract::Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease characterised by inflammation and demyelination of the central nervous system and is the best available animal model of multiple sclerosis (MS). Since previous studies have shown that EAE is less severe or is delayed in onset durin...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(03)00212-0
更新日期:2003-12-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2015-12-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2003-01-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章
doi:10.1016/s0022-510x(99)00218-x
更新日期:1999-10-31 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2007.08.030
更新日期:2008-03-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.jns.2007.12.004
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1984-03-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2019-03-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(96)05323-3
更新日期:1997-05-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2006-12-21 00:00:00
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pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:2009-11-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00