当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease.

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease.

Abstract：

:Electron transport chain (ETC) dysfunction has been claimed to contribute to the expression of neurodegenerative disorders. We have investigated the effects of the treatment with rivastigmine, a commonly used cholinesterase inhibitor, on lymphocyte mitochondria of patients with Alzheimer's disease (AD). Increased enzymatic activities of diverse complexes and oxidative capacity of the ETC were found. Enhanced mitochondrial ETC function may contribute to the beneficial effects of rivastigmine on clinical manifestations of AD.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Casademont J,Miró O,Rodriguez-Santiago B,Viedma P,Blesa R,Cardellach F

doi

10.1016/s0022-510x(02)00319-2

subject

Has Abstract

pub_date

2003-01-15 00:00:00

pages

23-6

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022510X02003192

journal_volume

206

pub_type

临床试验,杂志文章

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