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Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis).

Abstract：

:Possible changes in brain metabolites in motor neurone disease/amytrophic lateral sclerosis (MND/ALS) were investigated using 1H magnetic resonance spectroscopy (MRS). A series of normal, healthy volunteer controls and MND patients have been studied using a spin echo (SE) 135 ms sequence, acquiring spectra from the region of the motor cortex. A further limited series of studies have been made for similar groups of volunteers and MND patients using a STEAM 20 ms sequence (stimulated echo). Analysis of the SE 135 ms spectra indicates there are statistically significant differences in the ratios of N-acetyl-aspartate to creatine and N-acetyl-aspartate to choline between controls and MND patients. Furthermore, metabolites identified using the STEAM 20 ms may be of great importance in the investigations of free radical mediated mechanisms, which have been postulated as being important contributors to the disease process. Preliminary results indicate that 1H MRS may provide important data to help understand the disease processes in MND and it could form a useful method for monitoring the effects of future trial treatment regimens.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Jones AP,Gunawardena WJ,Coutinho CM,Gatt JA,Shaw IC,Mitchell JD

doi

10.1016/0022-510x(95)00072-a

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

85-9

eissn

0022-510X

issn

1878-5883

pii

0022510X9500072A

journal_volume

129 Suppl

pub_type

临床试验,杂志文章

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