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Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing.

Abstract：

:The analysis of human skeletal muscle mitochondria revealed a progressive decline in mitochondrial respiratory chain function with age. The activities affected to the greatest extent were those of complexes I and IV which were decreased by 59% and 47% respectively between the ages of 20-30 years and 60-90 years of age. Quantitation of the 5 kb 'common' deletion of mtDNA using PCR revealed a progressive accumulation with age, from approximately 1 in 100,000 at 21 years to 1 in 10,000 at 56 years and 1 in 5000 at 78 years of age. The low absolute levels of this mutation are unlikely to contribute significantly to the observed mitochondrial dysfunction.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Cooper JM,Mann VM,Schapira AH

doi

10.1016/0022-510x(92)90270-u

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

91-8

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(92)90270-U

journal_volume

113

pub_type

杂志文章

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