Abstract:
:The REduction of Atherothrombosis for Continued Health (REACH) Registry is a large, international, prospective cohort of patients with atherothrombosis or multiple (>or=3) risk factors (MRFs) for atherothrombosis. Japanese patients (n=5193) were enrolled into the REACH registry between August and December 2004. One-year event rate in patients with cerebrovascular disease (CVD) was compared with that of patients with symptomatic atherothrombosis at other locations. After one year (n=5021), patients with CVD (n=1962) experienced a higher rate of non-fatal strokes than patients with coronary artery disease (CAD), peripheral artery disease (PAD) or MRFs alone (2.77% vs. 1.28%, 2.07% and 1.56%, respectively), but a lower rate of non-fatal myocardial infarction (0.45% vs. 1.31%, 0.77% and 0.66%, respectively). Patients with CVD plus disease in >or=1 other vascular bed had higher rates of cardiovascular events than patients with CVD alone. Overall, event rates including non-fatal stroke, non-fatal myocardial infarction and cardiovascular death were higher for patients with CVD and PAD than for patients with CVD and CAD. Asymptomatic carotid stenosis >or=70% and ankle-brachial index <0.9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Uchiyama S,Goto S,Matsumoto M,Nagai R,Origasa H,Yamazaki T,Shigematsu H,Shimada K,Yamada N,Bhatt DL,Steg PG,Ikeda Y,REduction of Atherothrombosis for Continued Health Registry Investigators.doi
10.1016/j.jns.2009.09.011subject
Has Abstractpub_date
2009-12-15 00:00:00pages
45-51issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(09)00853-3journal_volume
287pub_type
杂志文章,多中心研究abstract::In this study, we investigated the dose-effect relationship and safety of tissue plasminogen activator (tPA) for the treatment of intraventricular hemorrhage/hematoma (IVH) in rats. Adult male Sprague-Dawley rats were injected with autologous blood into the left lateral ventricle to establish IVH. Two hours later, Rin...
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