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Human brain lectin immunoreactive material in cerebrospinal fluids determined by enzyme immunoassay (EIA).

Abstract：

:A sensitive enzyme immunoassay (EIA) micromethod is described which can measure levels of a 14 kDa human brain lectin (HBL) in the cerebrospinal fluid (CSF) of patients submitted to CSF examination. The assay is based on the use of a polyclonal antibody to HBL and the simultaneous application of biotinylated and unlabeled HBL. Biotin was then reacted with a streptavidin-peroxidase (Strep-HRP) conjugate and the bound enzyme quantified with the substrate orthophenylenediamine (OPD). The assay requires only 50 microliters of CSF and is very sensitive: as little as 6 ng/ml of HBL 14 can be detected. In a blind-test screening, the mean (+/- SEM) concentration of the HBL immunoreactive material (HIM) in CSF was determined to be 72.4 +/- 6.6 ng/ml. Our results indicate that EIA measurement of HIM levels in the CSF may find useful applications in elucidating the involvement of HBL in the physiopathology of human nervous system (NS).

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Eloumami H,Caron M,Joubert R,Doinel C,Bladier D

doi

10.1016/0022-510x(91)90110-s

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

6-11

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(91)90110-S

journal_volume

105

pub_type

杂志文章

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