当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus.

CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus.

Abstract：

:The present study was performed to investigate the effects of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) antisense oligodeoxynucleotides (ODNs) on the assembly of the CaMKII·GluR6·PSD-95 signaling module, GluR6 serine phosphorylation and c-Jun N-terminal kinase 3 (JNK3) activation. A further aim was to determine the neuroprotective mechanism of CaMKII antisense ODNs against ischemia-reperfusion (I/R)-induced neuronal death in the rat hippocampus. CaMKII antisense ODNs were intracerebroventricularly infused to inhibit CaMKII expression once daily for 3 days prior to the induction of ischemia. Transient cerebral ischemia (15 min) and reperfusion were induced by four-vessel occlusion in Sprague-Dawley rats as an animal model for transient cerebral I/R. The expression of related proteins was examined by immunoprecipitation and immunoblotting. Neuronal death in the rat hippocampus was detected by histology and histochemistry. The results indicate that CaMKII antisense ODNs inhibit several of the processes that are normally induced by cerebral I/R, including CaMKII expression, increased CaMKII·GluR6·PSD-95 signaling module assembly, GluR6 serine phosphorylation and JNK3 activation. Alternatively, CaMKII antisense ODNs also exhibit a significant neuroprotective role against cerebral I/R-induced cell death. These results provide the first evidence that CaMKII antisense ODNs can exert neuroprotective effects on cerebral I/R-induced cell death. The possible molecular mechanisms underlying this effect include 1) an inhibition of CaMKII expression and subsequent suppression of the assembly of the CaMKII·GluR6·PSD-95 signaling module, 2) GluR6 serine phosphorylation, and 3) reduced JNK3 activation.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Liu Z,Xu J,Shen X,Lv C,Xu T,Pei D

doi

10.1016/j.jns.2011.10.012

subject

Has Abstract

pub_date

2012-03-15 00:00:00

pages

104-10

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(11)00615-0

journal_volume

314

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Axonal degeneration in the pathogenesis of multiple sclerosis.

    abstract：:Axonal degeneration plays an important role in the accumulation of disability in patients with multiple sclerosis (MS). Pathological studies have demonstrated axonal damage, particularly in areas of acute inflammation and demyelination, and in chronic lesions. Axonal loss and its progression, which is associated with ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(99)00178-1

    authors： Silber E,Sharief MK

    更新日期：1999-11-15 00:00:00

  • A patient with anti-aquaporin 4 antibody presenting hypersomnolence as the initial symptom and symmetrical hypothalamic lesions.

    abstract：:Here we report a case with positive serum anti-aquaporin 4 (AQP4) antibody who presented with hypersomnolence, symmetrical hypothalamic lesions and a reduced CSF orexin (hypocretin) level without optic nerve and spinal cord lesions on MRI. All of the symptoms, MRI finding and CSF orexin level improved simultaneously a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.08.031

    authors： Deguchi K,Kono S,Deguchi S,Morimoto N,Ikeda M,Kurata T,Ikeda Y,Matsuura T,Kanbayashi T,Takahashi T,Abe K

    更新日期：2012-01-15 00:00:00

  • [Peripheral neuropathy with cryoglobulinemia (author's transl)].

    abstract：:The author describe 2 personal observations of peripheral neuropathy with cryoglobulinemia and the 28 cases previously recorded are reviewed. The characteristics of the usually sensorimotor neuropathy are not specific. Nevertheless, the association with purpura, Raynaud's syndrome and leg ulcers and the inconstant agg...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90005-9

    authors： Géraud G,Laclergue JP,Bès A,Géraud J

    更新日期：1978-02-01 00:00:00

  • Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections.

    abstract：:We investigated regional cerebral blood flow (rCBF) patterns in Binswanger's disease (BD) patients using single photon emission computed tomography (SPECT). SPECT data on 22 patients with BD were analyzed using three-dimensional stereotactic surface projections (3D-SSP) and were compared with those of 22 patients with...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.02.011

    authors： Hanyu H,Shimuzu S,Tanaka Y,Takasaki M,Koizumi K,Abe K

    更新日期：2004-05-15 00:00:00

  • Epidemiology of multiple sclerosis in Arabs in Kuwait: a comparative study between Kuwaitis and Palestinians.

    abstract：:On December 31, 1988 there were 201 registered multiple sclerosis patients in Kuwait, an overall prevalence rate (PR) of 10.2 per 100,000; among them were 186 Arabs, of whom 72 were Palestinians and 51 Kuwaitis. Comparison of these two subgroups, who had a similar age distribution revealed that the disease was 2 1/2 t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90024-h

    authors： al-Din AS,Khogali M,Poser CM,al-Nassar KE,Shakir R,Hussain J,Behbahani K,Chadha G

    更新日期：1990-12-01 00:00:00

  • Tumor necrosis factor beta NcoI polymorphism is associated with inflammatory and metabolic markers in multiple sclerosis patients.

    abstract：:To evaluate the association between the tumor necrosis factor beta (TNF-β) NcoI polymorphism and inflammatory and metabolic markers in patients with multiple sclerosis (MS) patients and the association of these markers with disease disability, a 782 base-pair fragment of the TNF-β gene was amplified from genomic DNA a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.08.016

    authors： Kallaur AP,Oliveira SR,Simão AN,de Almeida ER,Morimoto HK,Alfieri DF,Pereira WL,Borelli SD,Kaimen-Maciel DR,Maes M,Reiche EM

    更新日期：2014-11-15 00:00:00

  • Cognitive effects of repetitive transcranial magnetic stimulation in patients with neurodegenerative diseases - clinician's perspective.

    abstract：:Repetitive transcranial magnetic stimulation (rTMS) represents a promising tool for studying and influencing cognition in people with neurodegenerative diseases. This procedure is noninvasive and painless, and it does not require the use of anesthesia or pharmacological substances. In this systematic critical review w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2014.01.037

    authors： Anderkova L,Rektorova I

    更新日期：2014-04-15 00:00:00

  • CIS case studies.

    abstract：:The onset of multiple sclerosis presents in 85% of cases as a subacute clinical event, the so-called clinically isolated syndrome. This event involves either focal or multifocal brain regions, most frequently the optic nerve, brainstem or spinal cord. The initial diagnosis of multiple sclerosis necessitates the demons...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/S0022-510X(09)71294-8

    authors： Tumani H,Sapunova-Mayer I,Süssmuth SD,Hirt V,Brettschneider J

    更新日期：2009-12-01 00:00:00

  • Reversible hemichorea associated with extracranial carotid artery stenosis.

    abstract：:Hemichorea associated with carotid artery occlusive disease is extremely rare. It has been recently suggested that carotid artery stenosis should be considered in the differential diagnosis of chorea, even in the absence of a preceding stroke or transient ischemic attack. Although the pathophysiology of this condition...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.08.068

    authors： Pareés I,Pujadas F,Hernández-Vara J,Lorenzo-Bosquet C,Cuberas G,Munuera J,Alvarez-Sabín J

    更新日期：2011-01-15 00:00:00

  • Hyperreactivity to myelin basic protein in multiple sclerosis.

    abstract：:Multiple sclerosis patients, control patients with other neurological diseases, and normal volunteers were assayed in a short-term 51chromium release assay for cell-mediated cytotoxicity against lymphocyte targets coated with myelin basic protein. Multiple sclerosis patients, compared to the other two groups, were hyp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90019-8

    authors： Eggers AE,Tarmin L,Plank CR,Gamboa ET

    更新日期：1981-11-01 00:00:00

  • New spectrum of the neurologic consequences of Zika.

    abstract：:Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barré Syndrome by an autoimmune response against peripheral myelin and/or axonal componen...

    journal_title：Journal of the neurological sciences

    pub_type： 社论

    doi：10.1016/j.jns.2017.10.046

    authors： Medina MT,Medina-Montoya M

    更新日期：2017-12-15 00:00:00

  • Increase in diameter of the axonal initial segment is an early change in amyotrophic lateral sclerosis.

    abstract：:We measured the diameter of the most distal portion of the axonal initial segment, the neuronal size of anterior horn cells, and the length of the axon hillock plus the initial segment (AH+IS) in the lumbar spinal cord in motor neuron disease. Three patients with amyotrophic lateral sclerosis (ALS) and one with lower ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90017-f

    authors： Sasaki S,Maruyama S

    更新日期：1992-07-01 00:00:00

  • The neurological consequences of explosives.

    abstract：:Neurological injuries produced by explosive blasts are the result of a cascade of events that begin with the initial explosion and evolve from the secondary, tertiary, and quaternary effects that the explosion engenders [Lavonis EJ. Blast Injuries. EMedicine.htm]. Only the results of the primary blast are predictable,...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2006.06.005

    authors： Finkel MF

    更新日期：2006-11-01 00:00:00

  • Infarct presenting with a combination of Wallenberg and posterior spinal artery syndromes.

    abstract：:This is the first report of a patient presenting with a combination of Wallenberg and posterior spinal artery syndromes. The patient developed right hemiplegia and sensory disturbances on the right side of the face and over the whole body. MRI showed infarcts of the cerebellum, medulla oblongata, and upper cervical co...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(00)00318-x

    authors： Manabe Y,Murase T,Iwatsuki K,Warita H,Hayashi T,Sakai K,Abe K

    更新日期：2000-06-15 00:00:00

  • A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family.

    abstract：:Benign familial neonatal convulsions (BFNC) are a rare autosomal dominant inherited epilepsy syndrome. Two voltage-gated potassium channel genes, KCNQ2 on chromosome 20q13.3 and KCNQ3 on chromosome 8q24, have been identified as the genes responsible for benign familial neonatal convulsions. By linkage analysis and mut...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.03.001

    authors： Tang B,Li H,Xia K,Jiang H,Pan Q,Shen L,Long Z,Zhao G,Cai F

    更新日期：2004-06-15 00:00:00

  • A longitudinal brain MRI study comparing the sensitivities of the conventional and a newer approach for detecting active lesions in multiple sclerosis.

    abstract：:Monthly dual-echo spin-echo (SE) and enhanced magnetic resonance imaging (MRI) after the injection of a standard dose (SD) of gadolinium (Gd) is the conventional approach to monitor short-term disease activity in multiple sclerosis (MS). In this study, the sensitivity of this approach in detecting active lesions in MS...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0022-510x(98)00144-0

    authors： Filippi M,Mastronardo G,Bastianello S,Rocca MA,Rovaris M,Gasperini C,Pozzilli C,Comi G

    更新日期：1998-07-15 00:00:00

  • Poorer physical fitness is associated with reduced structural brain integrity in heart failure.

    abstract：OBJECTIVE:Physical fitness is an important correlate of structural and functional integrity of the brain in healthy adults. In heart failure (HF) patients, poor physical fitness may contribute to cognitive dysfunction and we examined the unique contribution of physical fitness to brain structural integrity among patien...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.02.015

    authors： Alosco ML,Brickman AM,Spitznagel MB,Griffith EY,Narkhede A,Raz N,Cohen R,Sweet LH,Colbert LH,Josephson R,Hughes J,Rosneck J,Gunstad J

    更新日期：2013-05-15 00:00:00

  • Relation between Genetic markers and oligoclonal IgG in CSF in optic neuritis.

    abstract：:Thirty patients with acute, unilateral optic neuritis (ON), where re-examination after a mean observation period of 5 years did not reveal any aetiology, were investigated with regard to laboratory abnormalities frequently observed in multiple sclerosis. Eleven patients had oligoclonal IgG in CSF. In 5 of these a meas...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(76)90237-9

    authors： Stendahl L,Link H,Möller E,Norrby E

    更新日期：1976-01-01 00:00:00

  • The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats.

    abstract：:We investigated therapeutic effects of 4-methylcatechol (4-MC), a non-amine catechol compound, on streptozotocin (STZ)-induced diabetic neuropathy in rats. 4-MC is one of the potent stimulators of endogenous nerve growth factor (NGF) synthesis both in vitro and in vivo. Diabetic rats showed a statistically significant...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90048-5

    authors： Hanaoka Y,Ohi T,Furukawa S,Furukawa Y,Hayashi K,Matsukura S

    更新日期：1994-03-01 00:00:00

  • Postural control, falls and fear of falling in people with multiple sclerosis without mobility aids.

    abstract：:The purpose of the study was to determine the relationship between static postural control parameters to fear of falling and falling history in people with multiple sclerosis (MS) without mobility assistive devices. One-hundred and seven relapsing-remitting patients diagnosed with MS, 62 women aged 42.8 (S.D.=12.0), p...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.09.029

    authors： Kalron A,Achiron A

    更新日期：2013-12-15 00:00:00

  • Abnormal apocrine secretory cell mitochondria in a Huntington disease patient.

    abstract：:Over two decades, a 42-year old woman experienced the gradual onset of choreic involuntary movements, dystonia, and tics. Decreased caudate nucleus metabolism on 2-deoxyglucose PET scan and a heterozygous 49-CAG repeat expansion within the HTT gene established the diagnosis of HD, although no other family history was ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.08.034

    authors： Sidiropoulos C,LeWitt P,Hashimoto K

    更新日期：2012-12-15 00:00:00

  • Neurophysiological evidence for long-term repair of MS lesions: implications for axon protection.

    abstract：:After recovery from the acute stage of optic neuritis, a marked prolongation in the latencies of visual evoked potentials (VEPs) is typically observed. We have conducted three studies (one cross-sectional, two prospective), aimed at elucidating the progressive shortening of VEP latency, which frequently ensues over th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00428-8

    authors： Jones SJ,Brusa A

    更新日期：2003-02-15 00:00:00

  • Corticobasal degeneration presenting with progressive conduction aphasia.

    abstract：:We report the case of a woman with primary progressive aphasia (PPA) presenting with conduction aphasia. Neurological findings showed bilateral finger tremor and signe de poignet figé in her right hand. Memory, orientation, and activities of daily living were well preserved. Linguistic examination showed severe impair...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.12.017

    authors： Kimura N,Kumamoto T,Hanaoka T,Hazama Y,Nakamura K,Arakawa R

    更新日期：2008-06-15 00:00:00

  • Therapy adherence issues in Parkinson's disease.

    abstract：:The response to dopamine replacement therapy in patients with degenerative parkinsonism is variable. Reasons for a poor therapy response include the type of parkinsonism, comorbidities, and differential effects on clinical features. An additional explanation, which has received much less attention, is sub-optimal ther...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2009.08.053

    authors： Grosset D,European PD Therapy Compliance Study Group.

    更新日期：2010-02-15 00:00:00

  • ADC values of benign and high grade meningiomas and associations with tumor cellularity and proliferation - A systematic review and meta-analysis.

    abstract：INTRODUCTION:The aim of the present systematic review and meta-analysis was to compare the reported ADC values in different meningiomas and to analyze associations between ADC and cell count and proliferation activity in this tumor entity. METHOD:MEDLINE library and SCOPUS database were screened for papers investigati...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116975

    authors： Meyer HJ,Wienke A,Surov A

    更新日期：2020-08-15 00:00:00

  • Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study.

    abstract：:To elucidate the neuronal mechanism of the motor disturbances of the Rolling mouse Nagoya (rolling, genotype rol/rol), an experimental neurologic mutant mouse, we studied the physiological characteristics of neurons of the globus pallidus (GP) in rolling, comparing them with those of the behaviorally normal heterozygo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90139-c

    authors： Tomoda H,Kato M,Sakata S,Shima F

    更新日期：1992-10-01 00:00:00

  • A novel homozygous mutation of GJC2 derived from maternal uniparental disomy in a female patient with Pelizaeus-Merzbacher-like disease.

    abstract：:Pelizaeus-Merzbacher-like disease (PMLD) is an autosomal recessive hypomyelinating disorder of the central nervous system characterized by nystagmus, motor developmental delay, ataxia, and progressive spasticity. The gap junction protein gamma-2 gene (GJC2), encoding the gap junction protein connexin 47, is one of the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.04.017

    authors： Shimojima K,Tanaka R,Shimada S,Sangu N,Nakayama J,Iwasaki N,Yamamoto T

    更新日期：2013-07-15 00:00:00

  • Rapid sideline performance meets outpatient clinic: Results from a multidisciplinary concussion center registry.

    abstract：OBJECTIVE:This study investigated the utility of sideline concussion tests, including components of the Sports Concussion Assessment Tool, 3rd Edition (SCAT3) and the King-Devick (K-D), a vision-based test of rapid number naming, in an outpatient, multidisciplinary concussion center treating patients with both sports-r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.06.038

    authors： Kyle Harrold G,Hasanaj L,Moehringer N,Zhang I,Nolan R,Serrano L,Raynowska J,Rucker JC,Flanagan SR,Cardone D,Galetta SL,Balcer LJ

    更新日期：2017-08-15 00:00:00

  • Transient global amnesia: Only in already disrupted neuronal integrity of memory network?

    abstract：:Transient global amnesia is a well-described clinical syndrome; however, the pathophysiology is perplexing. Structural imaging indicates that punctuate hippocampal lesions are the representative pathophysiology, although functional neuroimaging studies have reported that the various regions comprising the episodic mem...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.05.035

    authors： Moon Y,Oh J,Kwon KJ,Han SH

    更新日期：2016-09-15 00:00:00

  • Neurological involvement and characterization in acquired hemophagocytic lymphohistiocytosis in adulthood.

    abstract：OBJECTIVE:To describe the neurological and neuroradiological features of acquired hemophagocytic lymphohistiocytosis (HLH) in adulthood by reporting a series of cases. METHODS:Ten consecutive patients who were diagnosed with HLH at Medstar Georgetown University Hospital and Walter Reed National Military Medical Center...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.07.017

    authors： Gratton SM,Powell TR,Theeler BJ,Hawley JS,Amjad FS,Tornatore C

    更新日期：2015-10-15 00:00:00