当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > CIS case studies.

CIS case studies.

Abstract：

:The onset of multiple sclerosis presents in 85% of cases as a subacute clinical event, the so-called clinically isolated syndrome. This event involves either focal or multifocal brain regions, most frequently the optic nerve, brainstem or spinal cord. The initial diagnosis of multiple sclerosis necessitates the demonstration of dissemination of pathology in time and space, as well as the exclusion of other alternative diagnoses, and can be challenging. Confirming a diagnosis of multiple sclerosis is a sensitive time for both patient and physician. The patient is faced with a difficult diagnosis and the physician must consider making difficult treatment decisions regarding therapy and follow-up care. This article presents a number of case studies that illustrate the diversity of presentation of clinically isolated syndrome and the challenges associated with confirming a diagnosis of multiple sclerosis.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Tumani H,Sapunova-Mayer I,Süssmuth SD,Hirt V,Brettschneider J

doi

10.1016/S0022-510X(09)71294-8

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

S7-10

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(09)71294-8

journal_volume

287 Suppl 1

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease.

    abstract：OBJECTIVE:We estimated the extent and pattern of cardiovascular autonomic dysfunction in dementia with Lewy bodies (DLB) as compared with that in Parkinson's disease (PD). METHODS:We performed meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy of the heart and hemodynamic autonomic function testing using the Valsalva...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.jns.2007.01.002

    authors： Oka H,Morita M,Onouchi K,Yoshioka M,Mochio S,Inoue K

    更新日期：2007-03-15 00:00:00

  • Posterior tibial and sural nerve somatosensory evoked potentials in dystrophia myotonica.

    abstract：:Somatosensory evoked potentials (SEPs) were recorded in a group of 18 patients with dystrophia myotonica and in 28 control subjects after stimulating the right and left posterior tibial (SEP-PT) and sural (SEP-S) nerves at the ankles. Recording electrodes were placed in the popliteal fossae, overlying the L3 spinal ve...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(85)90187-x

    authors： Bartel P,Lotz B,Robinson E,Van der Meyden C

    更新日期：1985-08-01 00:00:00

  • Cerebral disease in a nationwide Dutch pseudoxanthoma elasticum cohort with a systematic review of the literature.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is a monogenetic disease with progressive calcification of arteries and potential risk of stroke. To gain insights in the cerebral involvement in PXE, we evaluated prevalence and determinants of cerebral disease in our PXE cohort and performed a systematic review of literature....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2016.12.053

    authors： Kauw F,Kranenburg G,Kappelle LJ,Hendrikse J,Koek HL,Visseren FLJ,Mali WPT,de Jong PA,Spiering W

    更新日期：2017-02-15 00:00:00

  • A wide spectrum of variably periictal MRI abnormalities induced by a single or a cluster of seizures.

    abstract：BACKGROUND:Although predominantly reported in patients with status epilepticus, periictal MRI abnormalities have been reported in patients with a single or a cluster of seizures. Clinicians are often presented with a dilemma concerning the features of MRI abnormalities induced by a single or a cluster of seizures, as t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.06.001

    authors： Xiang T,Li G,Liang Y,Zhou J

    更新日期：2014-08-15 00:00:00

  • Light chain myeloma with oro-pharyngeal amyloidosis presenting as bulbar paralysis.

    abstract：:A 53-year old woman developed slowly progressive dysarthria, mild enlargement of the tongue and dysphagia since 1 year ago. All neurological differential diagnoses that could have explained the bulbar symptoms were excluded. The swallowing sequence was pathologic and immunoglobulins were markedly reduced. A bone marro...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)05326-9

    authors： Finsterer J,Wogritsch C,Pokieser P,Vesely M,Ulrich W,Grisold W,Mamoli B

    更新日期：1997-04-15 00:00:00

  • Proteinase induced demyelination. An electrophysiological and histological study.

    abstract：:The physiological and histological changes following injection of 10 microliter of proteinase K into the rat tibial nerve have been compared with those induced by proteinase K and specific inhibitor phenylmethylsulphonyl fluoride (PMSF) and also by rabbit experimental allergic neuritis (EAN) serum. Proteinase K and PM...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(87)90005-0

    authors： Westland K,Pollard JD

    更新日期：1987-12-01 00:00:00

  • Safety and pharmacodynamics of a novel recombinant botulinum toxin E (rBoNT-E): Results of a phase 1 study in healthy male subjects compared with abobotulinumtoxinA (Dysport®).

    abstract：:Naturally occurring botulinum toxin (BoNT) serotypes have different pharmacological features of therapeutic and aesthetic interest. This phase 1, double-blind, placebo-controlled study (EudraCT: 2016-002609-20) assessed safety, tolerability and pharmacodynamics (PD) of the first recombinant BoNT serotype E (rBoNT-E) v...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jns.2019.116516

    authors： Pons L,Vilain C,Volteau M,Picaut P

    更新日期：2019-12-15 00:00:00

  • Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT.

    abstract：BACKGROUND:Differential diagnosis between idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA) is often difficult in early disease stages. Since MSA is misdiagnosed as PD in more than 20% of the early stages, there is need for methods refining the differentiation of the two disease entities. In PD post...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(00)00279-3

    authors： Druschky A,Hilz MJ,Platsch G,Radespiel-Tröger M,Druschky K,Kuwert T,Neundörfer B

    更新日期：2000-04-01 00:00:00

  • Galantamine inhibits beta-amyloid aggregation and cytotoxicity.

    abstract：:The ability of galantamine (Reminyl) to inhibit the aggregation and toxicity of the beta-amyloid peptide (Abeta) was investigated. Galantamine showed concentration-dependent inhibition of aggregation of both Abeta 1-40 and Abeta 1-42, as determined by an ELISA method. Electron microscope studies of Abeta 1-40 incubate...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.01.024

    authors： Matharu B,Gibson G,Parsons R,Huckerby TN,Moore SA,Cooper LJ,Millichamp R,Allsop D,Austen B

    更新日期：2009-05-15 00:00:00

  • Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.

    abstract：:The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identifie...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2009.09.009

    authors： Palace J

    更新日期：2009-11-15 00:00:00

  • Hypnic headache: A review of 348 cases published from 1988 to 2018.

    abstract：:Hypnic headache (HH) is a rare benign disorder described initially by Raskin in 1988. It is characterized by recurrent nocturnal episodes of headache that periodically awaken the sleeping patient and usually occur in the elderly. This review aimed to describe the clinical features of the HH cases published in the lite...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2019.04.028

    authors： Silva-Néto RP,Santos PEMS,Peres MFP

    更新日期：2019-06-15 00:00:00

  • An epidemic of optic neuropathy in Tanzania: characterization of the visual disorder and associated peripheral neuropathy.

    abstract：:An epidemic of subacute bilateral visual failure has affected large numbers of teenagers and young adult Africans in coastal Tanzania since 1988. Previous work had indicated that many patients had sensory symptoms, but the nature of the neurological involvement was uncertain. The primary objective of this study was to...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(96)00162-1

    authors： Plant GT,Mtanda AT,Arden GB,Johnson GJ

    更新日期：1997-02-12 00:00:00

  • Involvement of legs and other body parts in patients with restless legs syndrome and its variants.

    abstract：BACKGROUND:Restless legs syndrome (RLS) is characterized by the urge to move the legs accompanied by movement-responsive, abnormal sensations, which worsen at rest and night. We investigated the distribution of sensory symptoms and clinical correlations in patients with RLS and its variants. METHODS:Eighty-nine patien...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116519

    authors： Suzuki K,Suzuki S,Miyamoto M,Miyamoto T,Matsubara T,Nozawa N,Arikawa T,Nakajima I,Hirata K

    更新日期：2019-12-15 00:00:00

  • Immunologic derangement in myotonic dystrophy--abnormal contact sensitization to dinitrochlorobenzene.

    abstract：:A broad spectrum of immunologic parameters was investigated in 13 cases of myotonic muscular dystrophy (MyD), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old woman having both MyD and a thymoma. This association between MyD and thymoma is probably coinciden...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90007-6

    authors： Kuroiwa Y,Sugita H,Toyokura Y,Mizoguchi M,Matsuo H,Nonaka Y

    更新日期：1980-08-01 00:00:00

  • Electron-microscopic X-ray microanalysis of normal and diseased human muscle.

    abstract：:Electron-microscopic X-ray microanalysis has been used to compare elemental concentrations in specific organelles in normal and diseased human muscle. An elevated calcium to phosphorus ratio has been found in both myonuclei and interstitial cell nuclei in diseased muscle compared with controls. Preliminary observation...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90129-0

    authors： Maunder CA,Yarom R,Dubowitz V

    更新日期：1977-09-01 00:00:00

  • Leigh-like syndrome with the T8993G mutation in the mitochondrial ATPase 6 gene: long-term follow-up discloses a slowly progressive course.

    abstract：:We describe the long-term clinical outcome of a patient with Leigh-like syndrome presenting as an early onset encephalopathy and peripheral neuropathy caused by the T8993G mutation in the mitochondrial DNA (mtDNA). Clinical follow-up for 20 years revealed a peculiar pattern of slow disease progression, characterized b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.11.023

    authors： Sobreira C,Marques W Jr,Pontes Neto OM,Santos AC,Pina Neto JM,Barreira AA

    更新日期：2009-03-15 00:00:00

  • Cognition in multiple sclerosis: Between cognitive reserve and brain volume.

    abstract：BACKGROUND:Several correlations between cognitive impairment (CI), radiologic markers and cognitive reserve (CR) have been documented in MS. OBIECTIVE:To evaluate correlation between CI and brain volume (BV) considering CR as possibile mitigating factor. METHODS:195 relapsing MS patients underwent a neuropsychologica...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.01.011

    authors： Fenu G,Lorefice L,Arru M,Sechi V,Loi L,Contu F,Cabras F,Coghe G,Frau J,Fronza M,Sbrescia G,Lai V,Boi M,Mallus S,Murru S,Porcu A,Barracciu MA,Marrosu MG,Cocco E

    更新日期：2018-03-15 00:00:00

  • Antigalactocerebroside serum demyelinates optic nerve in vivo.

    abstract：:Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of an...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90177-1

    authors： Sergott RC,Brown MJ,Silberberg DH,Lisak RP

    更新日期：1984-06-01 00:00:00

  • Infectious aneurysm of the intracavernous carotid artery occurring concomitantly with sphenoid sinusitis; an autopsy case report.

    abstract：:A previously healthy 56-year-old woman presented with right-sided ophthalmic pain and diplopia following headache and fever. A neurological examination revealed 3rd and 6th right cranial nerve palsies. Brain magnetic resonance imaging (MRI) and 3D-computed tomography (CT) angiography (CTA) showed right-sided sphenoid ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.11.017

    authors： Sugie M,Ihihara K,Nakano I,Kawamura M

    更新日期：2009-03-15 00:00:00

  • New options for early treatment of multiple sclerosis.

    abstract：:It is now possible to diagnose patients with multiple sclerosis earlier than previously due to the integration of MRI parameters into the diagnostic criteria. This provides a window of opportunity to treat patients with disease-modifying treatments before clinically-manifest tissue destruction and disability has emerg...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/S0022-510X(09)70004-8

    authors： Tintoré M

    更新日期：2009-02-01 00:00:00

  • Effects of chronic catecholamine depletions on muscarinic M1-receptor and its mRNA in rat brain.

    abstract：:In order to compare the effects of total catecholamine (CA) or noradrenaline (NA) depletions on cholinergic systems, and the mechanisms of receptor regulation in various brain regions, the regional changes in the levels of acetylcholine (ACh), M1-receptor (M1-R) binding, and M1-R messenger RNA (mRNA) were mainly exami...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90029-k

    authors： Asanuma M,Ogawa N,Haba K,Hirata H,Mori A

    更新日期：1992-07-01 00:00:00

  • Post-stroke epilepsy in Burkina Faso (West Africa).

    abstract：:Post-stroke epilepsy (PSE) is defined as "recurrent seizures following stroke with confirmed diagnosis of epilepsy". Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.06.038

    authors： Napon C,Dabilgou A,Kyelem J,Kaboré J

    更新日期：2016-09-15 00:00:00

  • Novel SACS mutation in a Belgian family with sacsin-related ataxia.

    abstract：:The authors describe the four patients in the first known Belgian family with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). A novel homozygous missense mutation, NM_014363.3: c.3491T>A in exon 9, of the SACS gene was identified in the present family, which results in an original amino acid of met...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.07.022

    authors： Ouyang Y,Segers K,Bouquiaux O,Wang FC,Janin N,Andris C,Shimazaki H,Sakoe K,Nakano I,Takiyama Y

    更新日期：2008-01-15 00:00:00

  • Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy.

    abstract：INTRODUCTION:Magnetization transfer ratio (MTR) histogram analysis can be used as a method for quantifying overall disease burden in MS. We studied correlations between MTR histogram and clinical parameters in MS subgroups. Contrary to earlier studies we placed special emphasis on the lower MTR range, to explore the ef...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00431-2

    authors： Kalkers NF,Hintzen RQ,van Waesberghe JH,Lazeron RH,van Schijndel RA,Adèr HJ,Polman CH,Barkhof F

    更新日期：2001-03-01 00:00:00

  • Overexpression of glucose-regulated protein 94 after spinal cord injury in rats.

    abstract：:Glucose-regulated protein (GRP) 94 is a member of the stress protein family, which is localized in the endoplasmic reticulum (ER). Spinal cord injury (SCI) induced ER stress that results in apoptosis. However, the role of GRP94 in injury of the central nervous system remains unknown. In this study, we performed SCI in...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.06.024

    authors： Xu D,Cui S,Sun Y,Bao G,Li W,Liu W,Zhu X,Fan J,Wang Y,Cui Z

    更新日期：2011-10-15 00:00:00

  • Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis.

    abstract：:The present study tested aspects of a novel etiological/pathogenetic hypothesis of Alzheimer's disease (AD), which proposes that alterations in endocrine regulation of peripheral calcium/phosphate (Ca/PO4) homeostasis (e.g., by glucocorticoids, vitamin D, etc.) induce and/or reflect altered calcium homeostasis and neu...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90261-5

    authors： Landfield PW,Applegate MD,Schmitzer-Osborne SE,Naylor CE

    更新日期：1991-12-01 00:00:00

  • Altered resting state functional network connectivity in children absence epilepsy.

    abstract：:Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with child...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.04.054

    authors： Li Q,Cao W,Liao X,Chen Z,Yang T,Gong Q,Zhou D,Luo C,Yao D

    更新日期：2015-07-15 00:00:00

  • The concept of vascular cognitive impairment.

    abstract：:Vascular dementia (VaD) is increasingly recognised to reflect an outmoded concept in that it identifies cases too late for preventive therapy to have an opportunity to prevent the development of dementia and uses a cognitive paradigm inappropriately based on Alzheimer's disease. A replacement is urgently required and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00253-8

    authors： Bowler JV

    更新日期：2002-11-15 00:00:00

  • Insulin resistance and cognitive test performance in elderly adults: National health and nutrition examination survey (NHANES).

    abstract：OBJECTIVES:To examine the relationship between homeostatic model of insulin resistance (HOMA-IR) and cognitive test performance among population≥60years in a national database. HYPOTHESIS:Higher insulin resistance is associated with lower cognitive test performance score in the population≥60years. PARTICIPANTS:We ana...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.11.031

    authors： Sherzai AZ,Shaheen M,Yu JJ,Talbot K,Sherzai D

    更新日期：2018-05-15 00:00:00

  • A novel homozygous mutation of GJC2 derived from maternal uniparental disomy in a female patient with Pelizaeus-Merzbacher-like disease.

    abstract：:Pelizaeus-Merzbacher-like disease (PMLD) is an autosomal recessive hypomyelinating disorder of the central nervous system characterized by nystagmus, motor developmental delay, ataxia, and progressive spasticity. The gap junction protein gamma-2 gene (GJC2), encoding the gap junction protein connexin 47, is one of the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.04.017

    authors： Shimojima K,Tanaka R,Shimada S,Sangu N,Nakayama J,Iwasaki N,Yamamoto T

    更新日期：2013-07-15 00:00:00