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Galantamine inhibits beta-amyloid aggregation and cytotoxicity.

Abstract：

:The ability of galantamine (Reminyl) to inhibit the aggregation and toxicity of the beta-amyloid peptide (Abeta) was investigated. Galantamine showed concentration-dependent inhibition of aggregation of both Abeta 1-40 and Abeta 1-42, as determined by an ELISA method. Electron microscope studies of Abeta 1-40 incubated in the presence of galantamine revealed fibrils that were disordered and clumped in appearance. MTT and lactate dehydrogenase assays, employing SH-SY5Y human neuroblastoma cells, showed that galantamine reduced the cytotoxicity induced by Abeta 1-40. Galantamine also dramatically reduced Abeta 1-40-induced cellular apoptosis in these cells. There is some evidence that galantamine may not be acting purely as a symptomatic treatment. Disease-modifying effects of the drug could be due to an additional effect on Abeta aggregation and/or toxicity.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Matharu B,Gibson G,Parsons R,Huckerby TN,Moore SA,Cooper LJ,Millichamp R,Allsop D,Austen B

doi

10.1016/j.jns.2009.01.024

subject

Has Abstract

pub_date

2009-05-15 00:00:00

pages

49-58

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(09)00045-8

journal_volume

280

pub_type

杂志文章

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