Abstract:
:Polyglutamine (poly-Q) diseases are late-onset neurodegenerative disorders arising from the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract of glutamine residues. This kind of mutant proteins may be aggregated and accumulated, and thereby enhance cellular oxidative stress. In one of our previous studies (Free Radic. Res. 2003;37:1307-17), we found that alteration in the leukocyte mtDNA content is very sensitive to the level of oxidative stress in blood. Thus, we proposed that leukocyte mtDNA content may be used as a biomarker to predict the severity of clinical manifestation of poly-Q diseases. We recruited 50 healthy subjects and 114 patients with poly-Q diseases, including spinal cerebellar atrophy 2/3, spinal bulbar muscular atrophy, and Huntington chorea. We found that mtDNA in leukocytes was depleted in patients with poly-Q diseases (P<0.05). Moreover, the results showed that patients with lower mtDNA content more frequently manifested multiple-symptom disorders and had high CAG repeat numbers in the mutant genes. In conclusion, we suggest that leukocyte mtDNA content correlates with the length of GAG repeat and may serve as an index of the severity of poly-Q diseases.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Liu CS,Cheng WL,Kuo SJ,Li JY,Soong BW,Wei YHdoi
10.1016/j.jns.2007.07.016subject
Has Abstractpub_date
2008-01-15 00:00:00pages
18-21issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(07)00480-7journal_volume
264pub_type
杂志文章abstract::The present single center, double-blind, delayed start study was conducted to examine possible symptomatic and disease-modifying effects of GM1 ganglioside in Parkinson's disease (PD). Seventy-seven subjects with PD were randomly assigned to receive GM1 for 120 weeks (early-start group) or placebo for 24 weeks followe...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-15 00:00:00
abstract:PURPOSE:Brain interstitial fluid plays an important role in the excretion of metabolic waste products into the cerebrospinal fluid through perivascular spaces (PVS). To investigate the normal function of PVS in healthy elderly individuals, we assessed the relationship between PVS and white matter hyperintensity (WMH) o...
journal_title:Journal of the neurological sciences
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更新日期:2019-03-15 00:00:00
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2003-11-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1981-08-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:2018-12-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1979-07-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(93)90296-b
更新日期:1993-02-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2007.04.021
更新日期:2007-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2017-05-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2008.01.011
更新日期:2008-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jns.2018.10.022
更新日期:2019-01-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(92)90061-o
更新日期:1992-09-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:2007-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2009-08-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-05-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(95)00295-d
更新日期:1996-03-01 00:00:00