Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity.

Abstract:

:We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barré syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM+GBS) affecting a 24-year-old woman from Cúcuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed by serum reverse transcriptase-polymerase chain reaction (RT-PCR) and convalescent ZIKV IgG antibodies. With intensive care treatment, respiratory support, steroids, and intravenous immunoglobulin (IVIg), patient survived with residual flaccid paraparesis. She had preexisting immunity against Chikungunya virus (CHIKV) and Dengue virus (DENV) acquired before the arrival of ZIKV in Colombia. From reports in the Caribbean, Central and South America we review 19 cases of ZIKV-associated TM, encephalitis and ADEM occurring after a mean latent period of 10.5 days (range 1-96) post-infection. Although GBS and ADEM are usually considered post-infectious and associated with development of antibodies against peripheral nerve and CNS epitopes, we postulate that our case of ADEM+GBS is para-infectious, induced by acute ZIKV neurotropism boosted by active immunity against other arboviruses. Animal models of ZIKV demonstrated strong viral neurotropism enhanced by passive immunity with antibodies against arboviruses such as West Nile virus, CHIKV, or DENV. These considerations are relevant to prevent potential ZIKV vaccine-induced reactions involving central and peripheral nervous system.

journal_name

J Neurol Sci

authors

Mancera-Páez O,Román GC,Pardo-Turriago R,Rodríguez Y,Anaya JM

doi

10.1016/j.jns.2018.09.028

subject

Has Abstract

pub_date

2018-12-15 00:00:00

pages

47-53

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(18)30390-3

journal_volume

395

pub_type

杂志文章,评审
  • Prevalence of migraine headache and its weight on neurological burden in Africa: a 43-year systematic review and meta-analysis of community-based studies.

    abstract:BACKGROUND:Headache burden is not adequately explored in Africa. Here, we measured weighted migraine prevalence from community-based studies in Africa. METHODS:PubMed search was employed using terms 'headache in Africa' AND/OR 'migraine in Africa' for published literature from 1970 until January 31, 2014. PRISMA was a...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jns.2014.04.019

    authors: Woldeamanuel YW,Andreou AP,Cowan RP

    更新日期:2014-07-15 00:00:00

  • Neurophysiological evidence for long-term repair of MS lesions: implications for axon protection.

    abstract::After recovery from the acute stage of optic neuritis, a marked prolongation in the latencies of visual evoked potentials (VEPs) is typically observed. We have conducted three studies (one cross-sectional, two prospective), aimed at elucidating the progressive shortening of VEP latency, which frequently ensues over th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-510x(02)00428-8

    authors: Jones SJ,Brusa A

    更新日期:2003-02-15 00:00:00

  • Separation of cerebrospinal fluid specific proteins -- a methodological study. Part I.

    abstract::A method for preparative separation of cerebrospinal fluid specific proteins by affinity chromatography and isoelectric focusing is described. It has been tested on CSF from a group of human patients suffering from TIA. The advantage of the method is the production of a protein pattern easy to survey by eye. The sensi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(80)90132-x

    authors: Wikkelsøo C,Blomstrand C,Rönnbäck L

    更新日期:1980-01-01 00:00:00

  • A novel A781V mutation in the CSF1R gene causes hereditary diffuse leucoencephalopathy with axonal spheroids.

    abstract::We report a family with a novel CSF1R mutation causing hereditary diffuse leucoencephalopathy with axonal spheroids. Family members presented with neuropsychiatric and behavioural symptoms, with subsequent development of motor symptoms and gait disturbance. MRI brain showed extensive white matter change with a frontal...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.06.007

    authors: Ahmed R,Guerreiro R,Rohrer JD,Guven G,Rossor MN,Hardy J,Fox NC

    更新日期:2013-09-15 00:00:00

  • Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese.

    abstract:BACKGROUND:Ischemic stroke is the end phenotype of a complex interaction between various genetic and environmental factors. OBJECTIVE:We aimed to explore association of two lipid-relevant genetic variants and conventional risk factors with risk of having ischemic stroke in Northern Han Chinese. METHODS:Genotyping was...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2008.09.013

    authors: Wang B,Zhao H,Zhou L,Dai X,Wang D,Cao J,Niu W

    更新日期:2009-01-15 00:00:00

  • Rebleeding from ruptured intracranial aneurysms in North Eastern Province of Japan. A cooperative study.

    abstract:OBJECT:Rebleeding from ruptured intracranial aneurysms is a major cause of death and disability. With regard to the factors that precipitate the rebleeding and influence the time course after initial bleeding, previous reports differ in their results, and the number of patients investigated was not sufficient for valid...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jns.2007.01.074

    authors: Tanno Y,Homma M,Oinuma M,Kodama N,Ymamoto T

    更新日期:2007-07-15 00:00:00

  • Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizures.

    abstract:PURPOSE:Increased concentrations of the nervous-system-specific proteins neuron-specific enolase (NSE) and S-100 protein (S-100) have been measured with lesions in the CNS. Elevated levels of serum NSE (s-NSE) have been found in status epilepticus, but also after single epileptic seizures. Because larger studies addres...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(00)00478-0

    authors: Palmio J,Peltola J,Vuorinen P,Laine S,Suhonen J,Keränen T

    更新日期:2001-01-15 00:00:00

  • Optic neuritis in an ethnically diverse population: higher risk of atypical cases in patients of African or African-Caribbean heritage.

    abstract:PURPOSE:To investigate the presence of an ethnicity bias within patients presenting with optic neuritis in London. DESIGN:Observational cross-sectional study. METHODS:The ethnicity profile of all patients attending a neuro-ophthalmology clinic in central London with acute optic neuritis over a 16month period (n=86) w...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2011.08.030

    authors: Storoni M,Pittock SJ,Weinshenker BG,Plant GT

    更新日期:2012-01-15 00:00:00

  • Alpha-interferon and isoprinosine in adult-onset subacute sclerosing panencephalitis.

    abstract::We report eight patients with adult-onset subacute sclerosing panencephalitis (SSPE), of which, four were treated with oral isoprinosine and four with intraventricular alpha-interferon plus oral isoprinosine. One of the four patients treated with oral isoprinosine died within two months, and the disease progressed in ...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0022-510x(98)00302-5

    authors: Gokcil Z,Odabasi Z,Demirkaya S,Eroglu E,Vural O

    更新日期:1999-01-01 00:00:00

  • Effect of mild cognitive impairment on balance.

    abstract:OBJECTIVE:To investigate the effect of mild cognitive impairment (MCI) on balance. METHODS:87 subjects with subjective memory impairment were enrolled, and subdivided into two groups, MCI and non-MCI, according to diagnostic criteria of amnestic subtype of MCI according to the 1999 MCI international panel (Current Con...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2011.02.031

    authors: Shin BM,Han SJ,Jung JH,Kim JE,Fregni F

    更新日期:2011-06-15 00:00:00

  • Relation between the increase in the diffusional permeability of the blood-central nervous system barrier and other changes during the development of experimental allergic encephalomyelitis in the Lewis rat.

    abstract::The reduction in the effectiveness of the blood-brain and blood-spinal cord barriers, previously seen in rats at the height of the acute episode of experimental allergic encephalomyelitis, has now been measured at various stages in the development of the disease up to 60 days after inoculation with guinea pig spinal c...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(83)90147-8

    authors: Daniel PM,Lam DK,Pratt OE

    更新日期:1983-08-01 00:00:00

  • Electrophysiological observations on the spinal cord of the normal and dystrophic mouse.

    abstract::A method of carrying out electrophysiological experiments on the mouse spinal cord is described. The conduction velocity in the spinal dorsal roots (DR) of the normal mouse was in the range 10-100 m sec-1 and in the ventral roots (VR) 50-70 m sec-1. In the dystrophic mutant (129 ReJ dy/dy) the conduction velocity for ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(77)90005-3

    authors: Biscoe TJ,Headley PM,Martin MR,Stirling CA

    更新日期:1977-01-01 00:00:00

  • A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients.

    abstract::The present single center, double-blind, delayed start study was conducted to examine possible symptomatic and disease-modifying effects of GM1 ganglioside in Parkinson's disease (PD). Seventy-seven subjects with PD were randomly assigned to receive GM1 for 120 weeks (early-start group) or placebo for 24 weeks followe...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jns.2012.10.024

    authors: Schneider JS,Gollomp SM,Sendek S,Colcher A,Cambi F,Du W

    更新日期:2013-01-15 00:00:00

  • Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry.

    abstract:OBJECTIVES:Though much information exists about the diagnosis, treatment, and epidemiology of myasthenia gravis (MG), a comprehensive data registry and biorepository is critical to better understand disease mechanisms, treatment outcomes, and the impact of treatment strategies. We aimed to design and implement the "Exp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.116830

    authors: Anil R,Kumar A,Alaparthi S,Sharma A,Nye JL,Roy B,O'Connor KC,Nowak RJ

    更新日期:2020-07-15 00:00:00

  • Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer's disease: a meta-analysis.

    abstract:BACKGROUND:CYP2D6 gene encoding CYP2D6 enzyme belonging to the cytochrome P450 system has aroused long attention being a candidate gene for Alzheimer's disease (AD), but the results remain inconsistent and underpowered. OBJECTIVES:To investigate the contradictory results, the effect of single CYP2D6 polymorphism- CYP2...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jns.2014.05.033

    authors: Lu Y,Qin X,Li S,Zhang X,He Y,Peng Q,Deng Y,Wang J,Xie L,Li T,Zeng Z

    更新日期:2014-08-15 00:00:00

  • GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding.

    abstract:OBJECTIVE:GM1 ganglioside has been suggested as a treatment for Parkinson's disease (PD), potentially having symptomatic and disease modifying effects. The current pilot imaging study was performed to examine effects of GM1 on dopamine transporter binding, as a surrogate measure of disease progression, studied longitud...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jns.2015.06.028

    authors: Schneider JS,Cambi F,Gollomp SM,Kuwabara H,Brašić JR,Leiby B,Sendek S,Wong DF

    更新日期:2015-09-15 00:00:00

  • Susceptibility of human skeletal muscle culture to influenza virus infection. Part 2. Ultrastructural cytopathology.

    abstract::Cultured post-fused human skeletal muscle monolayers exposed to WSN influenza A virus were analyzed by scanning and transmission electron microscopy. At 12-14h post-inoculation (p.i.), affected mononuclear cells retracted from the cell surface, but remained anchored to the substrate by taut filar processes. Retraction...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(78)90162-4

    authors: Miranda AF,Gamboa ET,Armstrong CL,Hsu KC

    更新日期:1978-03-01 00:00:00

  • Covert persistence of mdx mouse myopathy is revealed by acute and chronic effects of irradiation.

    abstract::To compare muscle fiber loss in young and old mdx mice, we have blocked regeneration in one leg with a high dose (18 Gy) of X-rays administered at two ages; 16 days, just prior to the onset of the myopathy, and 15 weeks, when the myopathy is considered to be quiescent. Mice were examined 4 days after irradiation to lo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(99)00061-1

    authors: Pagel CN,Partridge TA

    更新日期:1999-04-01 00:00:00

  • Ocular myasthenia gravis - How effective is low dose prednisone long term?

    abstract:INTRODUCTION:Controversy persists on the best treatment to control ocular myasthenia gravis (OMG) and reduce conversion to generalized myasthenia gravis (GMG). We hypothesized that low dose prednisone could accomplish both in a cohort of OMG patients followed after three years. METHODS:We reviewed the records of 168 p...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.117274

    authors: Verma R,Wolfe GI,Kupersmith MJ

    更新日期:2021-01-15 00:00:00

  • Incidence of rotational vertigo in supratentorial stroke: a prospective analysis of 112 consecutive patients.

    abstract:BACKGROUND:Single cases with hemispheric, cortical or subcortical, ischemic lesions presenting with rotational vertigo (RV), that challenge the notion of infratentorial or peripheral generation of RV have been published, but the incidence of this symptom in a larger series is unknown. The aim of this study was to inves...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2009.11.015

    authors: Anagnostou E,Spengos K,Vassilopoulou S,Paraskevas GP,Zis V,Vassilopoulos D

    更新日期:2010-03-15 00:00:00

  • [Ultrastructural study of a chordoma].

    abstract::An ultrastructural study of a case of sacral chordoma is reported. The cell type was monomorphic. The epithelial nature and the secretory function of the tumour cells was obvious in view of their content of desmosomes and the presence of mucopolysaccharide in the ergastoplasm and in the extracellular space. Because of...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(75)90157-4

    authors: Tripler MF,Hassoun J,Toga M

    更新日期:1975-07-01 00:00:00

  • What is the validity of an "abnormal" evoked or event-related potential in MS? Auditory and visual evoked and event-related potentials in multiple sclerosis patients and normal subjects.

    abstract::The predictive validity of evoked potentials (EPs) and event-related potentials (ERPs) in multiple sclerosis (MS) has not yet been fully investigated, as only the sensitivity of these tests has sofar been reported. EPs (short, middle and long latency auditory evoked potentials and visual evoked potentials) and ERPs (v...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(92)90087-2

    authors: van Dijk JG,Jennekens-Schinkel A,Caekebeke JF,Singh A,Zwinderman AH

    更新日期:1992-05-01 00:00:00

  • Reciprocal expression of dystrophin and utrophin in muscles of Duchenne muscular dystrophy patients, female DMD-carriers and control subjects.

    abstract::We examined muscle biopsies from patients with Duchenne muscular dystrophy (DMD: 39 patients) and Becker muscular dystrophy (BMD: 11 patients), female DMD-carriers (4 patients), and control subjects (26 persons) for the expression of dystrophin and utrophin. Control subjects showed all fibers to be dystrophin-positive...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(93)90190-a

    authors: Mizuno Y,Nonaka I,Hirai S,Ozawa E

    更新日期:1993-10-01 00:00:00

  • Altered tumor growth factor beta mRNA expression is associated with thymectomy-related clinical remission in myasthenia gravis.

    abstract::Clinical remission in myasthenia gravis after thymectomy and immune suppressive treatment may be reflected by changes of immunoregulatory cytokines. Mononuclear cells from paired blood samples from fifteen patients with myasthenia gravis before and after thymectomy and immunosuppressive therapy were examined by in sit...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(97)00104-4

    authors: Weissert R,Melms A,Link H

    更新日期:1997-10-03 00:00:00

  • Accelerometer cut-points derived during over-ground walking in persons with mild, moderate, and severe multiple sclerosis.

    abstract:BACKGROUND:There has been increased interest in objectively quantifying time spent in moderate-to-vigorous physical activity (MVPA) using accelerometry as an outcome among persons with multiple sclerosis (MS). This requires development of a cut-point for interpreting the rate of accelerometer output based on its associ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2014.02.024

    authors: Sandroff BM,Riskin BJ,Agiovlasitis S,Motl RW

    更新日期:2014-05-15 00:00:00

  • Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor α (TNFα) release in a rat brain.

    abstract::Blast-induced neurotrauma (BINT) is a major medical concern yet its etiology is largely undefined. Complement activation may play a role in the development of secondary injury following traumatic brain injury; however, its role in BINT is still undefined. The present study was designed to characterize the complement s...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2012.02.002

    authors: Dalle Lucca JJ,Chavko M,Dubick MA,Adeeb S,Falabella MJ,Slack JL,McCarron R,Li Y

    更新日期:2012-07-15 00:00:00

  • Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis.

    abstract::Few data exist on the effects of specific Alzheimer's disease (AD)-related mutations on cognitive function. We present neuropsychological test results in eight members of a large kindred with variant Alzheimer's disease (VarAD) due to a deletion of the presenilin 1 (PS-1) gene, encompassing exon 9. The disease was neu...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2003.10.020

    authors: Verkkoniemi A,Ylikoski R,Rinne JO,Somer M,Hietaharju A,Erkinjuntti T,Viitanen M,Kalimo H,Haltia M

    更新日期:2004-03-15 00:00:00

  • Untapped targets in multiple sclerosis.

    abstract::Multiple sclerosis is a chronic inflammatory disease of the white and grey matter which results in irrevocable axonal and neuronal damage. Grey matter injury is widespread and reflects disability to a greater extent than do white matter lesions. Growing understanding of the immunopathology of multiple sclerosis is lea...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/S0022-510X(11)70003-X

    authors: Meinl E

    更新日期:2011-12-01 00:00:00

  • Hypnic headache: A review of 348 cases published from 1988 to 2018.

    abstract::Hypnic headache (HH) is a rare benign disorder described initially by Raskin in 1988. It is characterized by recurrent nocturnal episodes of headache that periodically awaken the sleeping patient and usually occur in the elderly. This review aimed to describe the clinical features of the HH cases published in the lite...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2019.04.028

    authors: Silva-Néto RP,Santos PEMS,Peres MFP

    更新日期:2019-06-15 00:00:00

  • Understanding the pathology of vascular cognitive impairment.

    abstract::The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed vascular cognitive impairment (VCI), and of mixed dementia (Alzheimer disease+vascular encephalopathy) are a matter of discussion and no validated neuropathologic criteria for these disorders are currently available. In Western mem...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2004.11.029

    authors: Jellinger KA

    更新日期:2005-03-15 00:00:00