Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT.

Abstract:

BACKGROUND:Differential diagnosis between idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA) is often difficult in early disease stages. Since MSA is misdiagnosed as PD in more than 20% of the early stages, there is need for methods refining the differentiation of the two disease entities. In PD postganglionic involvement of the autonomic nervous system (ANS) predominates whereas in MSA the ANS is mainly affected in its preganglionic structures. The functional integrity of postganglionic cardiac sympathetic neurons can be investigated using I-123-metaiodobenzylguanidine-single photon emission computed tomography (MIBG-SPECT). OBJECTIVES:We investigated whether I-123-MIBG-SPECT allows to differentiate between early stages of PD and MSA in patients not yet requiring L-dopa therapy. METHODS:Thirty patients (10 PD and 20 MSA patients) underwent MIBG-SPECT and evaluation of heart rate variability (HRV). Patients on any medication interfering with MIBG-accumulation were excluded from the study. Cardiac perfusion was evaluated by myocardial scintigraphy. RESULTS:The median cardiac MIBG uptake was significantly decreased in PD as well as MSA patients compared to controls (P<0.001). However, in the PD group MIBG uptake was significantly lower than in MSA (P=0.03). Even in PD patients without clinical signs of autonomic failure, MIBG uptake was significantly lower than in MSA patients (P=0.03). Analysis of heart rate parameters did not differentiate between PD and MSA patients. The median coefficient of variation was significantly smaller in PD and MSA patients compared to control subjects. CONCLUSIONS:Our study shows that MIBG-SPECT identifies autonomic cardiac dysfunction in very early stages of both, PD and MSA. More importantly, the technique facilitates differentiation of MSA and PD in the early stages. The different pathology with prominent peripheral, postganglionic sympathetic dysfunction in PD and primarily central and preganglionic lesions in MSA accounts for a lower MIBG uptake in PD compared to MSA patients.

journal_name

J Neurol Sci

authors

Druschky A,Hilz MJ,Platsch G,Radespiel-Tröger M,Druschky K,Kuwert T,Neundörfer B

doi

10.1016/s0022-510x(00)00279-3

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

3-12

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(00)00279-3

journal_volume

175

pub_type

杂志文章
  • Detection and management of cardiomyopathy in female dystrophinopathy carriers.

    abstract::Regular health checkups for mothers of patients with Duchenne muscular dystrophy have been performed at National Hospital Organization Tokushima Hospital since 1994. Among 43 mothers participated in this study, 28 dystrophinopathy carriers were identified. Skeletal and cardiac muscle functions of these subjects were e...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2017.12.024

    authors: Adachi K,Hashiguchi S,Saito M,Kashiwagi S,Miyazaki T,Kawai H,Yamada H,Iwase T,Akaike M,Takao S,Kobayashi M,Ishizaki M,Matsumura T,Mori-Yoshimura M,Kimura E

    更新日期:2018-03-15 00:00:00

  • Hereditary parkinsonism with multiple system degeneration: beneficial effect of anticholinergics, but not of levodopa.

    abstract::Two siblings who exhibited hereditary parkinsonism with pyramidal signs and cerebellar ataxia are reported. Anticholinergics had a dramatic beneficial effect in both cases, but levodopa did not. This responsiveness, which is similar to that reported in patients with Joseph's disease, suggests dysfunction of an "indire...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(94)90028-0

    authors: Mitsui T,Kawai H,Sakoda S,Miyata M,Saito S

    更新日期:1994-09-01 00:00:00

  • COVID-19 in multiple sclerosis patients and risk factors for severe infection.

    abstract::Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics of MS associated with worse COVID-19 outcomes. Therefore, we conducted a multicenter...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jns.2020.117147

    authors: Chaudhry F,Bulka H,Rathnam AS,Said OM,Lin J,Lorigan H,Bernitsas E,Rube J,Korzeniewski SJ,Memon AB,Levy PD,Schultz L,Javed A,Lisak R,Cerghet M

    更新日期:2020-11-15 00:00:00

  • Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect.

    abstract::A variety of neurological conditions and disease states are accompanied by pseudobulbar affect (PBA), an emotional disorder characterized by uncontrollable outbursts of laughing and crying. The causes of PBA are unclear but may involve lesions in neural circuits regulating the motor output of emotional expression. Sev...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2006.06.030

    authors: Miller A,Panitch H

    更新日期:2007-08-15 00:00:00

  • Distribution of intramembranous particle size in the muscle plasma membrane of the mdx mouse.

    abstract::We investigated whether the reduced intramembranous particles (IMP) in the muscle plasma membrane in mdx mice reflects a preferential depletion of a particular size of the IMP. The experiments were performed using the freeze-fracture method to analyze the frequency distribution of the size of IMP, the density of ortho...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(96)05350-6

    authors: Ito H,Yoshimura T,Tsujihata M,Nagataki S

    更新日期:1997-05-29 00:00:00

  • Parabiotic reinnervation in normal and dystrophic mice. Part 2. Morphological studies.

    abstract::The technique of parabiotic reinnervation has been used to test directly the neurogenic theory of the aetiology of muscular dystrophy in mice. Dystrophic muscles contain significantly fewer muscle fibres than their normal controls; they also have a much broader spectrum of fibre size because of a much higher proportio...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(75)90212-9

    authors: Johnson MA,Montgomery A

    更新日期:1975-11-01 00:00:00

  • Clinical characteristics, misdiagnosis and outcomes of patients with low-flow spinal arteriovenous fistulas.

    abstract:OBJECTIVE:To describe the clinical characteristics, delay to diagnosis and post-intervention outcomes of patients with low-flow spinal arteriovenous fistulas (SAVFs). METHODS:In this retrospective observational study, we reviewed all patients with low-flow SAVFs angiographically diagnosed at our institution between 20...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.116863

    authors: Murphy OC,Hedjoudje A,Salazar-Camelo A,Pardo CA,Gailloud P

    更新日期:2020-06-15 00:00:00

  • Early expression of serum neutrophil gelatinase-associated lipocalin (NGAL) is associated with neurological severity immediately after traumatic brain injury.

    abstract:PURPOSE:Intracranial bleeding and inflammatory reactions are common consequences of traumatic brain injury (TBI). Neutrophil gelatinase-associated lipocalin (NGAL), an iron-handling and acute phase protein, may participate in the pathogenesis of TBI. Therefore, we hypothesize that NGAL may be of high diagnostic and the...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2016.07.060

    authors: Zhao J,Chen H,Zhang M,Zhang Y,Qian C,Liu Y,He S,Zou Y,Liu H

    更新日期:2016-09-15 00:00:00

  • Metabolic implications of distal atrophy. Carbohydrate metabolism in centronuclear myopathy.

    abstract::Centronuclear myopathy, like myotonic dystrophy, is characterized by muscle wasting and type 1 fiber atrophy. To determine whether this disorder might include a derangement in carbohydrate metabolism similar to that in myotonic dystrophy, 3 comparably wasted patients with centronuclear myopathy, myotonic dystrophy, an...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(78)90127-2

    authors: Moxley RT 3rd,Griggs RC,Markesbery WR,Vangelder V

    更新日期:1978-12-01 00:00:00

  • In vitro cellular responsiveness in multiple sclerosis patients to a purified measles virus nuclear core and to other viral antigens.

    abstract::The Clausen modification of the peripheral blood buffy coat leukocyte migration test was used to test patients with multiple sclerosis, normal subjects and patients with other neurologic diseases for cell-mediated immunity to commercial measles virus, purified nuclear core material from a human neurotropic strain of m...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(76)90026-5

    authors: Ciongoli AK,Lisak RP,Zweiman B,Koprowski H,Waters D

    更新日期:1976-07-01 00:00:00

  • Sensory symptoms in cranial dystonia: a potential role in the etiology?

    abstract::Cranial dystonia is normally considered as a pure movement disorder. Sensory symptoms have not received much attention, but we found ill-defined pain, discomfort, distortion of sensory modalities, 'phantom' kinetic or postural sensations in the orofacial areas subsequently involved by the dyskinesia in all of 11 conse...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(93)90318-s

    authors: Ghika J,Regli F,Growdon JH

    更新日期:1993-06-01 00:00:00

  • Isolated limb sensory disturbance accompanied with sudden deafness from vertebral artery dissection: a case report.

    abstract::A 52-year-old male presented with right sudden deafness and left isolated limb sensory disturbance following posterior neck pain. An examination revealed a mild degree of right sensory neural hearing loss and decreased pain and thermal sensation in the left side below the L3 level. Brain MRI showed a small lesion in t...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2007.05.026

    authors: Shibata K,Otuka K,Nishimura Y,Kondo H,Ikeda N,Iwata M

    更新日期:2007-12-15 00:00:00

  • Insulin resistance and cognitive test performance in elderly adults: National health and nutrition examination survey (NHANES).

    abstract:OBJECTIVES:To examine the relationship between homeostatic model of insulin resistance (HOMA-IR) and cognitive test performance among population≥60years in a national database. HYPOTHESIS:Higher insulin resistance is associated with lower cognitive test performance score in the population≥60years. PARTICIPANTS:We ana...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2017.11.031

    authors: Sherzai AZ,Shaheen M,Yu JJ,Talbot K,Sherzai D

    更新日期:2018-05-15 00:00:00

  • How long does it take to diagnose cervical dystonia?

    abstract:BACKGROUND:Dystonia is a neurological disorder characterized by involuntary twisting movements and postures. The neck is among the most commonly affected regions, and diagnosis can be made readily through a simple clinical evaluation. The goal of this study was to explore how long it took patients to receive a diagnosi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.08.028

    authors: Tiderington E,Goodman EM,Rosen AR,Hapner ER,Johns MM 3rd,Evatt ML,Freeman A,Factor S,Jinnah HA

    更新日期:2013-12-15 00:00:00

  • Laser evoked potentials in amyotrophic lateral sclerosis.

    abstract::The pathophysiological mechanism of the pain in ALS is still unclear. The aim of the study was to evaluate the laser evoked potentials (LEPs) in ALS patients in relation to their clinical features. Twenty-four ALS patients were selected. Pain features were assessed and their intensity was measured by a 0-10 VAS. LEPs ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2009.09.023

    authors: Simone IL,Tortelli R,Samarelli V,D'Errico E,Sardaro M,Difruscolo O,Calabrese R,Francesco Vde V,Livrea P,de Tommaso M

    更新日期:2010-01-15 00:00:00

  • An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study.

    abstract:OBJECTIVE:The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.117268

    authors: Hindenes LB,Håberg AK,Mathiesen EB,Vangberg TR

    更新日期:2021-01-15 00:00:00

  • Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurons.

    abstract::Deprenyl, a selective monoamine oxidase B inhibitor, is effective in Parkinson's disease, and can slow the cognitive deterioration in Alzheimer's disease. However, it is not known whether this agent has a trophic effect on spinal motor neurons. We have studied neurotrophic effects of deprenyl on spinal motor neurons, ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(94)90235-6

    authors: Iwasaki Y,Ikeda K,Shiojima T,Kobayashi T,Tagaya N,Kinoshita M

    更新日期:1994-08-01 00:00:00

  • Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.

    abstract::Recently, TAR DNA-binding protein of 43-kDa (TDP-43) was identified as a major component of ubiquitinated neuronal cytoplasmic inclusions observed in lower motor neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions. We herein investigated the relationship b...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2007.12.016

    authors: Fujita Y,Mizuno Y,Takatama M,Okamoto K

    更新日期:2008-06-15 00:00:00

  • gamma delta+ T cells are increased in patients with Parkinson's disease.

    abstract::The etiology of Parkinson's disease is mainly unknown. Immune abnormalities have been reported, including the occurrence of autoantibodies against neuronal structures and abnormal T cell functions. gamma delta+ T cells represent a recently recognized T cell subpopulation which is considered to play a role in immune re...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(94)90154-6

    authors: Fiszer U,Mix E,Fredrikson S,Kostulas V,Olsson T,Link H

    更新日期:1994-01-01 00:00:00

  • Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

    abstract::Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(99)00079-9

    authors: Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

    更新日期:1999-05-01 00:00:00

  • A serial study of regional cerebral blood flow deficits in patients with left anterior thalamic infarction: anatomical and neuropsychological correlates.

    abstract::Thalamic damage is associated with a variety of neuropsychological dysfunctions, as well as strategic infarct dementia. However, only a limited number of reports in the medical literature have discussed the correlation between the clinical findings and the specific functional changes observed on images. We investigate...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2007.09.016

    authors: Shim YS,Kim JS,Shon YM,Chung YA,Ahn KJ,Yang DW

    更新日期:2008-03-15 00:00:00

  • Adjuvant intra-arterial rt-PA injection at the initially deployed solitaire stent enhances the efficacy of mechanical thrombectomy in acute ischemic stroke.

    abstract:BACKGROUND:Both intra-arterial recombinant tissue plasminogen activator (rt-PA) and stent retrieval are effective for treating acute ischemic stroke. The goal of this study was to evaluate the effectiveness of stent retrieval combined with intra-arterial rt-PA administration via micro-catheter (called the complex techn...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2018.01.012

    authors: Yi TY,Chen WH,Wu YM,Zhang MF,Lin DL,Lin XH

    更新日期:2018-03-15 00:00:00

  • Direct observation during surgery shows preservation of cerebral microcirculation in patients with traumatic brain injury.

    abstract:OBJECTIVE:To describe the alterations of the cortical microcirculation of the brain (blood flow and vessel density) in TBI patients who and compare them with a control group. METHODS:Prospective and observational study in a third-level university hospital. Cortical microcirculation in the brain was directly observed u...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.03.044

    authors: Pérez-Bárcena J,Romay E,Llompart-Pou JA,Ibáñez J,Brell M,Llinás P,González E,Merenda A,Ince C,Bullock R

    更新日期:2015-01-01 00:00:00

  • Vascular risk factors and intensity of cognitive dysfunction in MCI.

    abstract::Patients with Mild Cognitive Impairment (MCI) have a greater risk of developing dementia than general population. Lots of evidence suggests that cardiovascular risk factors appear more often in the MCI than in general population The aim of this study was to evaluate association between cardiovascular risk factors and ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2007.01.034

    authors: Siuda J,Gorzkowska A,Opala G,Ochudło S

    更新日期:2007-06-15 00:00:00

  • Covert persistence of mdx mouse myopathy is revealed by acute and chronic effects of irradiation.

    abstract::To compare muscle fiber loss in young and old mdx mice, we have blocked regeneration in one leg with a high dose (18 Gy) of X-rays administered at two ages; 16 days, just prior to the onset of the myopathy, and 15 weeks, when the myopathy is considered to be quiescent. Mice were examined 4 days after irradiation to lo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(99)00061-1

    authors: Pagel CN,Partridge TA

    更新日期:1999-04-01 00:00:00

  • CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.

    abstract::In five patients with cerebral manifestation of Wilson's disease, copper was measured in CSF, serum, urine and liver, and ceruloplasmin was determined in CSF and serum. CSF copper was found to be elevated in all cases, especially in the four examined before therapy. Two patients were followed up for a period of 3 year...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(87)90275-9

    authors: Weisner B,Hartard C,Dieu C

    更新日期:1987-06-01 00:00:00

  • Corticosteroids treatment.

    abstract::Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of cli...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2004.04.019

    authors: Pozzilli C,Marinelli F,Romano S,Bagnato F

    更新日期:2004-08-15 00:00:00

  • Factors associated with tonic-clonic seizures in patients with drug-resistant mesial temporal epilepsy.

    abstract:PURPOSE:Among different seizure types, tonic-clonic seizures are more significant because they are more often associated with morbidity. No prior study has been done to investigate risk factors associated with tonic-clonic seizures in patients with mesial temporal epilepsy. METHODS:In this retrospective study, all dru...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.10.022

    authors: Asadi-Pooya AA,Rostami C,Rabiei AH,Sperling MR

    更新日期:2015-12-15 00:00:00

  • Evaluation parameters between intra-voxel incoherent motion and diffusion-weighted imaging in grading and differentiating histological subtypes of meningioma: A prospective pilot study.

    abstract:PURPOSE:To prospectively evaluate the usage of intra-voxel incoherent motion (IVIM) magnetic resonance imaging (MRI) parameters in grading and differentiating histological subtypes of meningiomas and in comparing their ability with the traditional diffusion-weighted imaging (DWI) parameter (apparent diffusion coefficie...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2016.11.037

    authors: Yiping L,Kawai S,Jianbo W,Li L,Daoying G,Bo Y

    更新日期:2017-01-15 00:00:00

  • [Ultrastructural study of a chordoma].

    abstract::An ultrastructural study of a case of sacral chordoma is reported. The cell type was monomorphic. The epithelial nature and the secretory function of the tumour cells was obvious in view of their content of desmosomes and the presence of mucopolysaccharide in the ergastoplasm and in the extracellular space. Because of...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(75)90157-4

    authors: Tripler MF,Hassoun J,Toga M

    更新日期:1975-07-01 00:00:00