当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > S100B and ADMA in cerebral small vessel disease and cognitive dysfunction.

S100B and ADMA in cerebral small vessel disease and cognitive dysfunction.

Abstract：

BACKGROUND:Glial cell activation and endothelial dysfunction are thought to contribute to the pathophysiology of cerebral small vessel disease (SVD). The purpose of the present study was to determine if levels of S100B, a protein highly expressed in glial cells, and asymmetric dimethylarginine (ADMA), which promotes endothelial dysfunction, are elevated in the serum of patients with SVD and correlate with their cognitive functioning. METHODS:The serum levels of S100B and ADMA were measured with enzyme-linked immunosorbent assays in 210 patients with SVD and 207 controls. Cognitive functioning was evaluated using the Montreal Cognitive Assessment. SVD lesions were categorized as isolated lacunar infarcts (ILI), multiple lacunar infarcts, leukoaraiosis (LA), and LA with cerebral atrophy using magnetic resonance imaging. RESULTS:SVD patients were significantly older, and more likely to have hypertension, diabetes, and heart disease, and smoke compared to controls (Ps<0.05). Plasma levels of S100B and ADMA were significantly higher in SVD patients (Ps<0.05), though only S100B was significant after adjusting for the confounding factors. Subtype analyses indicated that ADMA levels were differentially altered depending on lesion type, particularly in cases with ILI and LA (Ps<0.05). Compared with controls, SVD patients had significant cognitive impairment that was most profound in the cases with LA (all Ps<0.05). Levels of S100B and ADMA were significantly correlated with cognitive decline in patients with LA (P<0.05). CONCLUSION:S100B and ADMA are elevated in SVD, and are associated with cognitive impairment in patients with LA lesions.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Gao Q,Fan Y,Mu LY,Ma L,Song ZQ,Zhang YN

doi

10.1016/j.jns.2015.04.031

subject

Has Abstract

pub_date

2015-07-15 00:00:00

pages

27-32

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(15)00241-5

journal_volume

354

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Separation of cerebrospinal fluid specific proteins -- a methodological study. Part I.

    abstract：:A method for preparative separation of cerebrospinal fluid specific proteins by affinity chromatography and isoelectric focusing is described. It has been tested on CSF from a group of human patients suffering from TIA. The advantage of the method is the production of a protein pattern easy to survey by eye. The sensi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90132-x

    authors： Wikkelsøo C,Blomstrand C,Rönnbäck L

    更新日期：1980-01-01 00:00:00

  • Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease.

    abstract：:In addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of Alzheimer's disease (AD). Several factors have been postulated as causes or triggers of cellular apoptotic change. This study focused on a quantifiable relationship between phosphorylation si...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00410-0

    authors： Kobayashi K,Nakano H,Hayashi M,Shimazaki M,Fukutani Y,Sasaki K,Sugimori K,Koshino Y

    更新日期：2003-04-15 00:00:00

  • Transient resolution of bilateral tremor after unilateral thalamotomy, associated with focal injury of the corpus callosum: case report.

    abstract：:We present a patient with Parkinson's disease whose bilateral tremor transiently resolved after a unilateral left ventrolateral thalamotomy. The transient resolution of the bilateral tremor was associated with a focal thalamic lesion and a second lesion in the corpus callosum. The mechanism of this phenomenon may be r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)00236-h

    authors： Greene KA,Wallace RC,Fram EK,Shetter AG,Lieberman AN

    更新日期：1995-03-01 00:00:00

  • Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway.

    abstract：:Isoflavone formononetin is a typical phytoestrogen isolated from Chinese medical herb red clover. It has been reported that estrogens have neuroprotective properties, and dietary intake of phytoestrogens could reduce stroke injury in cerebral ischemia/reperfusion (I/R) animal models. In the present research, we sought...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.06.033

    authors： Liang K,Ye Y,Wang Y,Zhang J,Li C

    更新日期：2014-09-15 00:00:00

  • The acute effects of alcohol on plasma creatine kinase (CK) activity in the rat.

    abstract：:The acute effect of a single intraperitoneal dose of alcohol (2 g kg-1 body weight) was studied in normally fed rats anaesthetised with sodium pentabarbitone . Rapidly achieved high blood alcohol levels were accompanied by an equally rapid but transient 4-fold increase in the total creatine kinase (CK) activity in the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90153-9

    authors： Spargo E

    更新日期：1984-03-01 00:00:00

  • Increasing and persistent DWI changes in a patient with hereditary diffuse leukoencephalopathy with spheroids.

    abstract：:We report a case with genetically confirmed hereditary diffuse leukoencephalopathy with spheroids with distinctive MRI features. A 52-year-old woman with a family history of juvenile dementia presented with an 18-month history of progressive cognitive decline. Longitudinal magnetic resonance imaging studies of the bra...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.08.027

    authors： Terasawa Y,Osaki Y,Kawarai T,Sugimoto T,Orlacchio A,Abe T,Izumi Y,Kaji R

    更新日期：2013-12-15 00:00:00

  • Immunological relationship between a demyelinating RNA enveloped budding virus (Semliki Forest) and brain glycolipids.

    abstract：:A monoclonal antibody (MAb) raised against central nervous system (CNS) myelin (212) and a MAb (308) raised against brain with Semliki Forest virus (SFV) were both found to react against the same CNS glycolipids. Both these MAbs were also found to react strongly with SFV and against certain brain glycolipid fractions ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(86)90144-9

    authors： Khalili-Shirazi A,Gregson N,Webb HE

    更新日期：1986-11-01 00:00:00

  • Vascular dementia among elderly Arabs in Wadi Ara.

    abstract：:Dementia of the Alzheimer type (DAT) and vascular dementia (VaD) are the two major subtypes of dementia. In our epidemiological study of DAT in an Arab community in Wadi Ara, Israel, we found a high prevalence of late onset DAT. Illiteracy, smoking, diabetes mellitus (DM) and hypertension are very frequent in Wadi Ara...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00269-1

    authors： Bowirrat A,Friedland RP,Korczyn AD

    更新日期：2002-11-15 00:00:00

  • Molecular genetic analysis of Charcot-Marie-Tooth 1A duplication in Norwegian patients by quantitative photostimulated luminescence imaging.

    abstract：:Around 70% of Charcot-Marie-Tooth 1 (CMT1) cases are caused by a dominantly inherited 1.5-Mb duplication at 17p11.2-12 (CMT1A). Using photostimulated luminescence (PSL) imaging of MspI Southern blots, hybridization signals of the probe pVAW409R3a in relation to cohybridized probe SF85a, were densitometrically quantifi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00544-5

    authors： Aarskog NK,Aadland S,Gjerde IO,Vedeler CA

    更新日期：2001-07-15 00:00:00

  • Cerebral disease in a nationwide Dutch pseudoxanthoma elasticum cohort with a systematic review of the literature.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is a monogenetic disease with progressive calcification of arteries and potential risk of stroke. To gain insights in the cerebral involvement in PXE, we evaluated prevalence and determinants of cerebral disease in our PXE cohort and performed a systematic review of literature....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2016.12.053

    authors： Kauw F,Kranenburg G,Kappelle LJ,Hendrikse J,Koek HL,Visseren FLJ,Mali WPT,de Jong PA,Spiering W

    更新日期：2017-02-15 00:00:00

  • Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel.

    abstract：:High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and plasma B12 and folate levels. Seventy-nine AD patients and 156 controls from three Arab villages in northern Israel participated. Plasma tHcy, ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.08.011

    authors： Mizrahi EH,Bowirrat A,Jacobsen DW,Korczyn AD,Traore F,Petot GJ,Lerner AJ,Debanne SM,Adunsky A,Dibello PM,Friedland RP

    更新日期：2004-12-15 00:00:00

  • Development of a clinical score, PANDA, to predict delirium in stroke care unit.

    abstract：BACKGROUND AND PURPOSE:Delirium frequently complicates acute stroke and worsens outcomes. Because delirium is potentially preventable, predicting its occurrence is essential. Although several prediction scores have been proposed, nurses need to quickly predict delirium in stroke care units (SCUs). We aimed to develop a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116956

    authors： Nakamizo T,Kanda T,Kudo Y,Sugawara E,Hashimoto E,Okazaki A,Usuda M,Nagai T,Hara H,Johkura K

    更新日期：2020-08-15 00:00:00

  • Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d,l-HMPAO SPECT study.

    abstract：:We investigated regional cerebral blood flow (rCBF) using the [99mTc]-d,l-HMPAO technique with brain dedicated high resolution single photon emission computer tomography (SPECT) in 14 consecutive patients with amyotrophic lateral sclerosis (ALS), median age 62 years (45-77). Global CBF, expressed in % relative to the ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90204-x

    authors： Waldemar G,Vorstrup S,Jensen TS,Johnsen A,Boysen G

    更新日期：1992-01-01 00:00:00

  • Activation-flow coupling differentiates between vascular and Alzheimer type of dementia.

    abstract：:The activation-flow coupling describes a mechanism, which adapts local cerebral blood flow in accordance with the underlying neuronal activity. It was suggested that the mechanism helps in differentiation between Alzheimer and vascular type of dementia. We combined EEG and Doppler techniques and assessed integrity of ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.01.032

    authors： Rosengarten B,Paulsen S,Molnar S,Kaschel R,Gallhofer B,Kaps M

    更新日期：2007-06-15 00:00:00

  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status.

    abstract：:We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolu...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0022-510x(97)00156-1

    authors： Rohowsky-Kochan C,Molinaro D,Devereux C,Troiano R,Bansil S,Zito G,Wolansky L,Jotkowitz A,Denny T,Oleske J,Dowling P,Cook SD

    更新日期：1997-11-25 00:00:00

  • Inhibition of synaptosomal [3H]glutamate uptake and [3H]glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro.

    abstract：:Synaptosomes and plasma membrane preparations from brain of 30-day-old rats were incubated with glutaric acid at final concentrations ranging from 10 nM to 1 mM for the determination of glutamate uptake and binding, respectively. [3H]Glutamate uptake into synaptosomes was inhibited by approximately 50% by 1 mM glutari...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00307-x

    authors： Porciúncula LO,Dal-Pizzol A Jr,Coitinho AS,Emanuelli T,Souza DO,Wajner M

    更新日期：2000-02-15 00:00:00

  • Anoxia in vitro does not induce neuronal swelling or death.

    abstract：:To improve the understanding of neuronal cell swelling in cerebral ischemia, cell volume regulation, viability, intracellular electrolytes, and lactate production of Neuro-2A neuroblastoma cells were studied using an in vitro model. The volume regulatory capacity of Neuro-2A cells was assessed after incubation in hypo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：

    authors： Mackert BM,Staub F,Peters J,Baethmann A,Kempski O

    更新日期：1996-07-01 00:00:00

  • The effects of Cannabis on hallucinations in Parkinson's disease patients.

    abstract：:Cannabis use is on the rise both as medical treatment and recreational use. There is evidence that cannabis can cause hallucinations and psychosis especially with heavy and prolonged use. Parkinson's disease (PD) carries an increased risk for development of hallucinations and psychosis. It is possible that cannabis ma...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2020.117206

    authors： Cravanas B Jr,Frei K

    更新日期：2020-12-15 00:00:00

  • Expression of the human groEL stress-protein homologue in the brain and spinal cord.

    abstract：:A monoclonal antibody (ML30), previously shown to identify a human mitochondrial protein epitope homologous with the groEL heat-shock protein of bacteria (hsp60), was used in an immunohistochemical survey of the central nervous system in patients dying with no evidence of neurological disease and in tissue from patien...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90111-b

    authors： Martin JE,Swash M,Mather K,Leigh PN

    更新日期：1993-09-01 00:00:00

  • Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury.

    abstract：:Thromboxane-prostacyclin imbalance may be an important determinant of platelet-vessel wall interactions that are vital in circulatory homeostasis. In experimental spinal cord injury, the vascular damage contributes substantially to the process of progressive secondary injury culminating in post-traumatic myelopathy. I...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90019-6

    authors： Hsu CY,Halushka PV,Spicer KM,Hogan EL,Martin HF

    更新日期：1988-01-01 00:00:00

  • HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases.

    abstract：:Histone deacetylases (HDACs), or lysine deacetylases (KDAC), are epigenetic regulators that catalyze the removal of acetyl moieties from the tails of lysine residues of histones and other proteins. To date, eighteen HDAC family members (HDAC1-11 and SIRT1-7) have been identified and grouped into four classes according...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2011.02.017

    authors： Li G,Jiang H,Chang M,Xie H,Hu L

    更新日期：2011-05-15 00:00:00

  • Familial intermittent ataxia with possible X-linked recessive inheritance. Two patients with abnormal pyruvate metabolism and a response to acetazolamide.

    abstract：:Five males in one kindred suffered from intermittent ataxia and one female may have been more mildly affected. The pattern of inheritance strongly suggests X-linkage. Cerebral pathology in one case had some features of Leigh's disease. A defect in pyruvate metabolism was found in two cases. Acetazolamide gave a tempor...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90059-5

    authors： Livingstone IR,Gardner-Medwin D,Pennington RJ

    更新日期：1984-04-01 00:00:00

  • Apolipoprotein E epsilon4 allele frequency in elderly depressed patients with and without cerebrovascular disease.

    abstract：:Late-onset depression (LOD) could be a very early manifestation of Alzheimer's disease (AD), although contradictory results have been reported. Cerebrovascular disease (CVD) may favor the development of LOD, and that the particular forms of vascular depression should be individualized. The Apolipoprotein E (ApoE) epsi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.01.038

    authors： Traykov L,Bayle AC,Latour F,Lenoir H,Seux ML,Hanon O,Péquignot R,Bert P,Moulin F,Cantegreil I,Wenisch E,Batouche F,Mehrabian S,Rotrou Jd,Rigaud AS

    更新日期：2007-06-15 00:00:00

  • Is maraviroc useful in multiple sclerosis patients with natalizumab-related progressive multifocal leukoencephalopathy?

    abstract：BACKGROUND:Despite the recent advances in the understanding of natalizumab (NTZ) related progressive multifocal leukoencephalopathy (PML) and its associated immune reconstitution inflammatory syndrome (PML-IRIS), the therapeutic options are still under investigated. In this context, the beneficial use of maraviroc is s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2017.05.018

    authors： Scarpazza C,Prosperini L,Mancinelli CR,De Rossi N,Lugaresi A,Capobianco M,Moiola L,Naldi P,Imberti L,Gerevini S,Capra R

    更新日期：2017-07-15 00:00:00

  • Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis.

    abstract：:Previously, we demonstrated that neuronal nitric oxide synthase (nNOS) is activated and promotes muscle atrophy in skeletal muscle during tail suspension, a model of unloading and denervation. Here, we examined patients with amyotrophic lateral sclerosis (ALS) and mutant (H46R) SOD1 transgenic (Tg) mice model using im...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.03.022

    authors： Suzuki N,Mizuno H,Warita H,Takeda S,Itoyama Y,Aoki M

    更新日期：2010-07-15 00:00:00

  • Monitoring brain tissue oxymetry: will it change management of critically ill neurologic patients?

    abstract：:Based on the assumption that brain ischemia and hypoxia are central causes of brain damage, the maintenance of an adequate tissue oxygenation is a primary objective in the field of neurocritical care. Thus, monitoring brain tissue oxymetry, allowing the possibility to discriminate between normal and critically impaire...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2007.04.026

    authors： Mazzeo AT,Bullock R

    更新日期：2007-10-15 00:00:00

  • Crossed cerebellar diaschisis and brain tumor biochemistry studied with positron emission tomography, [18F]fluorodeoxyglucose and [11C]methionine.

    abstract：:Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00019-7

    authors： Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

    更新日期：1998-01-01 00:00:00

  • Frontal lobe dysfunction in amyotrophic lateral sclerosis.

    abstract：:The aim of the present study was to investigate the involvement of frontal lobe dysfunction in amyotrophic lateral sclerosis (ALS) using ocular motor paradigms and neuropsychological testing. Fifty-one patients with ALS participated in the following ocular motor tasks: (1) a three-choice task and (2) a remembered sacc...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00683-9

    authors： Evdokimidis I,Constantinidis TS,Gourtzelidis P,Smyrnis N,Zalonis I,Zis PV,Andreadou E,Papageorgiou C

    更新日期：2002-03-15 00:00:00

  • Bilateral basal ganglia lesions as initial manifestation of CNS invasion in adult T-cell leukemia.

    abstract：:We describe the case of a 67-year-old man who exhibited unsteadiness in walking, topographical disorientation, and urinary incontinence. Neurological examination revealed somnolence and mild weakness in the lower limbs with slight rigidity in the upper limbs. Cerebrospinal fluid examination showed pleocytosis with "fl...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.01.035

    authors： Matsuo Y,Yamashita S,Honda S,Nakajima M,Ueda A,Hirahara T,Yamashita T,Maeda Y,Hirano T,Ando Y

    更新日期：2013-04-15 00:00:00

  • Treatment options: the latest evidence with galantamine (Reminyl).

    abstract：:Vascular dementia (VaD) has a great deal of overlap (in terms of features and symptoms) with Alzheimer's disease (AD). Mixed dementia, or AD with concomitant cerebrovascular disease (AD with CVD), is increasingly being recognized as a distinct clinical condition that occurs with substantial frequency. The robust evide...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00267-8

    authors： Erkinjuntti T

    更新日期：2002-11-15 00:00:00