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Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury.

Abstract：

:Thromboxane-prostacyclin imbalance may be an important determinant of platelet-vessel wall interactions that are vital in circulatory homeostasis. In experimental spinal cord injury, the vascular damage contributes substantially to the process of progressive secondary injury culminating in post-traumatic myelopathy. In this study, we found a time-dependent alteration of thromboxane-prostacyclin balance in the injured spinal cord with thromboxane dominance during the first 2 h: a time when maximal vascular injury is reflected by extravasation of 125I-labelled serum albumin. The thromboxane-prostacyclin imbalance reverted to favor prostacyclin by 18 h post-injury. This time-dependent alteration of thromboxane-prostacyclin balance should be considered in the planning of therapeutic attempts to prevent secondary injury by pharmacological modulation of platelet-vessel wall interaction.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Hsu CY,Halushka PV,Spicer KM,Hogan EL,Martin HF

doi

10.1016/0022-510x(88)90019-6

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

55-62

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(88)90019-6

journal_volume

83

pub_type

杂志文章

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