Abstract：
INTRODUCTION:TCS is a well-established technique for diagnosis of Parkinson's disease (PD). Volumetric 3D-TCS is a promising complementary approach for objective acquisition and analysis, in particular for less experienced sonographers. This study provides baselines for Parkinson detection (sensitivity and specificity), cutoff values and inter-rater agreement in 3D-TCS. METHODS:We performed 3D-TCS in 52 subjects (healthy controls and PD) bilaterally, and reconstructed in 3D space uni-laterally. Ipsi-lateral hyperechogenicities in the substantia nigra are manually segmented slice-by-slice in the 3D volume by two raters at different experience levels. ROC threshold analysis is performed and compared on features representing 3D volume and axial cross-sections (2.5D) of hyperechogenicities. Pearson correlation and intra-class correlation coefficients were evaluated for assessment of inter-rater agreement. RESULTS:50 subjects were included. Both raters achieved high classification accuracy with 2.5D/3D features extracted from 3D-TCS volumes (best results sensitivity/specificity/cut-off per rater: 84.6%/88.9%/25.0mm2; 77.8%/88.9%/95.9mm3). The inter-rater agreement in 3D was high (ICC(A,1) = 0.777, p < 10-3), the classification performance of both sonographers was statistically not significantly different. CONCLUSION:The study presents first baseline values for uni-lateral 3D-TCS examination, and finds no disadvantage of uni-lateral reconstructions compared to previous bi-lateral fusion. Volumetric 3D-TCS has potential for a high inter-rater agreement and accuracy in detection of PD, in particular for sonographers with less experience.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Plate A,Maiostre J,Levin J,Bötzel K,Ahmadi SAdoi
10.1016/j.jns.2018.12.001subject
Has Abstractpub_date
2019-02-15 00:00:00pages
16-21eissn
0022-510Xissn
1878-5883pii
S0022-510X(18)30487-8journal_volume
397pub_type
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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