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Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.

Abstract：

:We studied the effects of fasudil, a selective Rho-kinase inhibitor, on experimental autoimmune neuritis (EAN). Continuous parenteral administration of fasudil prevented the development of EAN induced by P0 peptide 180-199 in Lewis rats while it also reduced EAN severity when administered after disease onset. Immunohistochemical examination disclosed a marked decrease in the amount of inflammatory cell infiltration and attenuation of demyelination and axonal degeneration. Specific proliferation of lymphocytes from fasudil-treated rats in response to P0 peptide was significantly reduced as compared with those from phosphate-buffered saline (PBS)-treated rats. Fasudil treatment was associated with a significant reduction in secretion of IFN-γ; by contrast, secretion of IL-4 was almost the same in the fasudil- and PBS-treated groups. As a result, the IFN-γ/IL-4 ratio in the supernatant was significantly deceased in fasudil-treated rats compared with PBS-treated ones. Therefore, our results indicate a beneficial effect of selective blockade of Rho-kinase in animals with autoimmune inflammation of the peripheral nerves, and may provide a rationale for the selective blockade of Rho-kinase as a new therapy for Guillain-Barré syndrome.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Pineda AA,Minohara M,Kawamura N,Matsushita T,Yamasaki R,Sun X,Piao H,Shimokawa H,Kira J

doi

10.1016/j.jns.2011.03.031

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

115-20

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(11)00161-4

journal_volume

306

pub_type

杂志文章

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