Abstract：
BACKGROUND:CYP2D6 gene encoding CYP2D6 enzyme belonging to the cytochrome P450 system has aroused long attention being a candidate gene for Alzheimer's disease (AD), but the results remain inconsistent and underpowered. OBJECTIVES:To investigate the contradictory results, the effect of single CYP2D6 polymorphism- CYP2D6*4, together with CYP2D6 phenotypes on the risk of AD, was evaluated using a meta-analysis. METHODS:Electronic database search of PubMed, Embase and Cochrane Library was conducted up to Apr 17, 2014. Odds ratio (OR) along with the 95% confidence interval (CI) was calculated. Subgroup analysis was performed to examine the impact of CYP2D6 variants on different ethnic. Meta-regression was performed to explore possible source of heterogeneity. RESULTS:A total of 11 studies involving 643AD cases and 1375 controls were included for CYP2D6*4 polymorphism, and 4 studies consisted of 411AD cases and 603 controls were included for CYP2D6 phenotypes. With respect to CYP2D6*4 polymorphism, significantly increased risk of AD was found in allelic contrast model of A vs. G (OR=1.29, 95%CI=1.03-1.62, P=0.026), co-dominant genetic model AA vs. GG (OR=1.91, 95%CI=1.04-3.51, P=0.038); and recessive genetic model AA vs. AG+GG (OR=1.88, 95%CI=1.03-3.46, P=0.041) in the overall populations. Similar results were also indicated in subgroup analysis in Caucasians. As for CYP2D6 phenotypes, no significant association with AD was revealed. CONCLUSIONS:Our data support that the CYP2D6*4 polymorphism but not CYP2D6 phenotypes might be associated with increased AD risk, particularly in Caucasian populations.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Lu Y,Qin X,Li S,Zhang X,He Y,Peng Q,Deng Y,Wang J,Xie L,Li T,Zeng Zdoi
10.1016/j.jns.2014.05.033subject
Has Abstractpub_date
2014-08-15 00:00:00pages
15-22issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(14)00323-2journal_volume
343pub_type
杂志文章,meta分析abstract：:3',5'-Cyclic nucleotide phosphodiesterase (PDE) is known to play an important role in the regulation of cyclic nucleotide levels in various tissues including the muscle. Previous studies have estimated the level of this enzyme in several neuromuscular disorders but the results have been variable. Moreover, there was n...
journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,评审
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/j.jns.2018.04.009
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/j.jns.2003.08.012
更新日期：2004-01-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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更新日期：1994-07-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：1998-09-18 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2017-10-15 00:00:00
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pub_type： 杂志文章
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