当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system.

Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system.

Abstract：

:Mice were inoculated with herpes simplex virus (HSV) type 1 by gently scraping the skin of the nose with a fine needle. About 80% of the animals developed latent inapparent HSV infections in trigeminal ganglia. Virus was demonstrable for at least 6 months post inoculation (p.i.) by cocultivation of ganglionic tissue with GMK cells. Histologically, trigeminal ganglia revealed infiltrations of inflammatory cells even 6 months p.i. In addition, lesions occurred in the brainstem corresponding to the entry of trigeminal roots, trigeminal tracts and nuclei. Inflammatory cell infiltration, disruption of myelin sheaths and macrophages laden with myelin degradation products were observed 7 days p.i. Fourteen to 30 days p.i. electron microscopy demonstrated completely naked axons. In the transitional region of the trigeminal root denuded axons occurred in the central part of the region while the peripheral myelin, bordering the demyelinated central segments, was intact. Small areas of demyelination were still detectable 3 and 6 months p.i. but there were then also signs of remyelination. Possible mechanisms causing the demyelinations are discussed.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Kristensson K,Svennerholm B,Persson L,Vahlne A,Lycke E

doi

10.1016/0022-510x(79)90119-9

subject

Has Abstract

pub_date

1979-10-01 00:00:00

pages

253-63

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(79)90119-9

journal_volume

43

pub_type

杂志文章

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