当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus.

Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus.

Abstract：

:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors. (11)C-flumazenil (FMZ), the positron emission tomography (PET) GABA(A) receptor ligand, is a marker of cortical dysfunction. The objective of this study was to investigate the relationship between cognitive deficits and loss of neuronal integrity in ALS patients using (11)C-FMZ PET. Ten patients with ALS underwent both neuropsychological tests and (11)C-FMZ-PET. The binding potential (BP) of FMZ was calculated from (11)C-FMZ PET images. There were no significant correlations between the BP and most test scores except for the writing error index (WEI), which was measured by the modified Western Aphasia Battery - VB (WAB-IVB) test. The severity of writing error was associated with loss of neuronal integrity in the bilateral anterior cingulate gyrus with mild right predominance (n=9; x=4 mm, y=36 mm, z=4 mm, Z=5.1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Yabe I,Tsuji-Akimoto S,Shiga T,Hamada S,Hirata K,Otsuki M,Kuge Y,Tamaki N,Sasaki H

doi

10.1016/j.jns.2011.11.039

subject

Has Abstract

pub_date

2012-04-15 00:00:00

pages

55-9

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(11)00711-8

journal_volume

315

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Clinical trials for preventing post stroke cognitive impairment.

    abstract：:Post stroke dementia (PSD) develops in up to 40% of patients and often co-exists with Alzheimer's disease in the elderly. Unsurprisingly, the combination of stroke and dementia is associated with considerable morbidity and mortality, and is devastating to patients and carers. Limited trial evidence suggests that lower...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.08.052

    authors： Ankolekar S,Geeganage C,Anderton P,Hogg C,Bath PM

    更新日期：2010-12-15 00:00:00

  • Respiratory assistance with a non-invasive ventilator (Bipap) in MND/ALS patients: survival rates in a controlled trial.

    abstract：:Noninvasive ventilatory assistance, in ALS patients, with the bilevel intermittent positive air pressure (Bipap) was studied, in a prospective and controlled trial, by the authors. Twenty ALS bulbar patients, fulfilling El Escorial criteria for probable or definite disease, were selected. For the follow-up all patient...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0022-510x(95)00052-4

    authors： Pinto AC,Evangelista T,Carvalho M,Alves MA,Sales Luís ML

    更新日期：1995-05-01 00:00:00

  • Isolated unilateral oculomotor paresis in pure midbrain stroke.

    abstract：BACKGROUND AND PURPOSE:Pure midbrain stroke can cause isolated unilateral oculomotor paresis. We attempted to determine whether there is a difference in the oculomotor paresis pattern between pure midbrain infarction and midbrain hemorrhage. METHODS:Pure midbrain stroke patients who presented with isolated unilateral ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.03.012

    authors： Amano Y,Kudo Y,Kikyo H,Imazeki R,Yamamoto M,Amari K,Tanaka F,Johkura K

    更新日期：2015-04-15 00:00:00

  • Localization of olivo-cerebellar fibers in inferior cerebellar peduncle in man.

    abstract：:The localization of the olivo-cerebellar fibers in the inferior cerebellar peduncle was examined in a patient who showed severe degeneration of the left olivary nucleus due to an old hemorrhagic infarct in the contralateral cerebellum. Other precerebellar nuclei which send their cerebellipetal axons to the inferior ce...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90139-9

    authors： Iwata M,Hirano A

    更新日期：1978-10-01 00:00:00

  • Non-familial degenerative disease and atrophy of brainstem and cerebellum. Clinical and CT data in 47 patients.

    abstract：:We studied the clinical features of 47 patients with a non-hereditary degenerative disease and with atrophy of brainstem or cerebellum or both in CT scanning. There was no relation between the CT findings and duration or severity of the disease, nor with the kind of the neurological signs which comprised ataxia, a hyp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90073-v

    authors： Staal A,Meerwaldt JD,van Dongen KJ,Mulder PG,Busch HF

    更新日期：1990-03-01 00:00:00

  • Physical activity and subclinical MRI cerebral infarcts: the ARIC Study.

    abstract：BACKGROUND:We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. OBJECTIVES:We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2009.04.011

    authors： Dubbert PM,Penman AD,Evenson KR,Reeves RR,Mosley TH Jr

    更新日期：2009-09-15 00:00:00

  • Nonhomogeneous distribution of 5-hydroxyindoleacetic acid and homovanillic acid in the lumbar cerebrospinal fluid of man.

    abstract：:The volume of the lumbar sac measured in 4 subjects was found to be 15.5 ml. Exactly 15 ml of lumbar cerebrospinal fluid (L-CSF) was permitted to flow freely out during a lumbar puncture in 20 neurological patients and small samples of the L-CSF were collected in the beginning (sample 1), at the middle (sample 2), and...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90103-4

    authors： Jakupcević M,Lacković Z,Stefoski D,Bulat M

    更新日期：1977-03-01 00:00:00

  • The small sodium-channel blocking factor in the cerebrospinal fluid of multiple sclerosis patients is probably an oligopeptide.

    abstract：:An endogenous factor that is able to reduce the fast transient sodium current of excitable cells has been reported to exist in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. This was confirmed with nine clinically definite MS patients in the acute relapse. In order to purify and chemically identify...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00285-3

    authors： Aulkemeyer P,Hausner G,Brinkmeier H,Weber F,Würz A,Heidenreich F,Rüdel R

    更新日期：2000-01-01 00:00:00

  • Autonomic dysfunction in different subtypes of post-acute ischemic stroke.

    abstract：OBJECTIVES:Central autonomic impairment is frequent in ischemic stroke at acute or chronic stages. The mechanism by which these symptoms occur in patients with ischemic stroke has not been elucidated. This study sought to investigate cardiovascular autonomic function in patients with different subtypes of post-acute is...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.11.036

    authors： Xiong L,Leung HW,Chen XY,Leung WH,Soo OY,Wong KS

    更新日期：2014-02-15 00:00:00

  • Comparison of major cortical aminopeptidase activity in normal brain and brain from patients with Alzheimer's disease.

    abstract：:In order to develop a greater understanding of the importance of peptide catabolism in the intracellular protein degradation process in normal and pathological human brain, we have undertaken a systematic investigation of the aminopeptidase group of enzymes. Although a wide range of aminoacyl-7-amino-4-methylcoumarin ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90024-5

    authors： Mantle D,Lauffart B,Perry EK,Perry RH

    更新日期：1989-02-01 00:00:00

  • Temporal relationship between awakening and seizure onset in nocturnal partial seizures.

    abstract：:Clinical awakening can be seen just before or after seizure onsets. In this study we determined the time between onset of seizures and awakening in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE). Sixty-eight patients who underwent video-EEG monitoring with simultaneous PSG were retrospectiv...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.12.009

    authors： Yildiz FG,Tezer FI,Saygi S

    更新日期：2012-04-15 00:00:00

  • Characteristics of the ischemic stroke patients whose seizures occur at stroke presentation at a single institution in Eastern China.

    abstract：PURPOSE:We compared clinical characteristics and outcomes of the early-onset seizure post-stroke patients who had seizures occurring at stroke presentation (SSP) with other patients without SSP at a single institution in Eastern China. METHODS:We reviewed 20,947 ischemic stroke patients in our hospital electronic medi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.01.028

    authors： Cheng JH,Zhang Z,Ye Q,Ye ZS,Xia NG

    更新日期：2018-04-15 00:00:00

  • Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo).

    abstract：:Radiation-induced (RI) peripheral neuropathy is a rare and severe delayed complication of radiotherapy that is spontaneously irreversible, with no standard of treatment. We previously developed a successful antioxidant treatment in RI fibrosis and necrosis. Two patients with progressive worsening RI lumbosacral polyra...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.08.004

    authors： Delanian S,Lefaix JL,Maisonobe T,Salachas F,Pradat PF

    更新日期：2008-12-15 00:00:00

  • High-dose, frequently administered interferon beta therapy for relapsing-remitting multiple sclerosis must be maintained over the long term: the interferon beta dose-reduction study.

    abstract：:Long-term trials have demonstrated the continued efficacy of interferon (IFN) beta treatment in patients with relapsing-remitting (RR) multiple sclerosis (MS) during prolonged administration. The objective of the work was to evaluate the effects of reducing IFN beta administration frequency and total weekly dose in pa...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jns.2004.03.023

    authors： Barbero P,Verdun E,Bergui M,Pipieri A,Clerico M,Cucci A,Ricci A,Bergamasco B,Durelli L

    更新日期：2004-07-15 00:00:00

  • Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity.

    abstract：OBJECTIVE:To report the first histopathologic description of optic nerve demyelination from tacrolimus (FK 506) toxicity in the absence of toxic levels of tacrolimus in a patient presenting with asymmetric bilateral visual loss after 5 years of tacrolimus therapy. PATIENTS:We report a patient status post cardiac and r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.10.014

    authors： Venneti S,Moss HE,Levin MH,Vagefi MR,Brozena SC,Pruitt AA,Mourelatos Z,Trojanowski JQ,Galetta SL,Balcer LJ

    更新日期：2011-02-15 00:00:00

  • Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: effect on survival.

    abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is offered to amyotrophic lateral sclerosis (ALS) patients with severe dysphagia. Immediate benefits of PEG are adequate food intake and weight stabilization. However, the impact of PEG on survival is still uncertain. In this work we retrospectively evaluated the eff...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.02.016

    authors： Spataro R,Ficano L,Piccoli F,La Bella V

    更新日期：2011-05-15 00:00:00

  • Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques.

    abstract：:The pattern of mental dysfunction in multiple sclerosis (MS) is characteristic of the so-called subcortical dementia. Cognitive dysfunction results predominantly by the disruption of communication among cortical and subcortical areas, as a consequence of the white matter damage. As expected, studies with conventional ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(99)00282-8

    authors： Comi G,Rovaris M,Leocani L,Martinelli V,Filippi M

    更新日期：2000-01-15 00:00:00

  • Brain MRI findings in patients with Fabry disease.

    abstract：BACKGROUND:To evaluate the presence of ischemic and hemorrhagic lesions in brain MRI of patients with Fabry disease (FD). METHODS:Brain MRI studies in 46 consecutive patients were evaluated using classic sequences as well as GRE-weighted images, for ischemic lesions and chronic microbleed detection. Of the 36 adult pa...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.03.020

    authors： Reisin RC,Romero C,Marchesoni C,Nápoli G,Kisinovsky I,Cáceres G,Sevlever G

    更新日期：2011-06-15 00:00:00

  • Androgen receptor mRNA with increased size of tandem CAG repeat is widely expressed in the neural and nonneural tissues of X-linked recessive bulbospinal neuronopathy.

    abstract：:We detected androgen receptor (AR) mRNA expression in various tissues in the patients with X-BSNP and controls using reverse transcription polymerase chain reaction (RT-PCR) and Northern blot analysis. The AR mRNAs were expressed in a wide variety of tissues including the testis, scrotal skin, liver, skeletal and card...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90133-3

    authors： Doyu M,Sobue G,Kimata K,Yamamoto K,Mitsuma T

    更新日期：1994-12-01 00:00:00

  • Wrong-way deviation: contralateral conjugate eye deviation in acute supratentorial stroke.

    abstract：BACKGROUND AND PURPOSE:Supratentorial stroke can cause conjugate eye deviation directed contralateral to the affected side (wrong-way deviation). It is rare and thought to be associated exclusively with hemorrhagic stroke. We prospectively investigated the clinical features and prognostic significance of this wrong-way...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.06.010

    authors： Johkura K,Nakae Y,Yamamoto R,Mitomi M,Kudo Y

    更新日期：2011-09-15 00:00:00

  • Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles.

    abstract：:We have used light microscopic histomorphometry to quantify the developmental histopathological changes induced by muscular dystrophy in the soleus and extensor digitorum longus (EDL) muscles of the mdx mouse. We find that this X-linked disease exhibits early fibre necrosis with foci of invasive cells, clustering of a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(87)90219-x

    authors： Carnwath JW,Shotton DM

    更新日期：1987-08-01 00:00:00

  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status.

    abstract：:We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolu...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0022-510x(97)00156-1

    authors： Rohowsky-Kochan C,Molinaro D,Devereux C,Troiano R,Bansil S,Zito G,Wolansky L,Jotkowitz A,Denny T,Oleske J,Dowling P,Cook SD

    更新日期：1997-11-25 00:00:00

  • Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

    abstract：:Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00079-9

    authors： Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

    更新日期：1999-05-01 00:00:00

  • Hydroxychloroquine reduces microglial activity and attenuates experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:Microglial activation is thought to be a key pathophysiological mechanism underlying disease activity in all forms of MS. Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory properties that is widely used in the treatment of rheumatological diseases. In this series of experiments, we explo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.08.1525

    authors： Koch MW,Zabad R,Giuliani F,Hader W Jr,Lewkonia R,Metz L,Wee Yong V

    更新日期：2015-11-15 00:00:00

  • Analysis of the McLeod syndrome gene in three patients with neuroacanthocytosis.

    abstract：:McLeod syndrome is a rare X-linked disorder involving neurological defects and acanthocytosis. We examined the XK gene in three patients with neuroacanthocytosis, one of whom had cardiomyopathy, and his symptoms were very similar to those of McLeod syndrome. We found two new transversions (C to G at codon 204 and G to...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00067-1

    authors： Shizuka M,Watanabe M,Aoki M,Ikeda Y,Mizushima K,Okamoto K,Itoyama Y,Abe K,Shoji M

    更新日期：1997-09-10 00:00:00

  • Treatment options: the latest evidence with galantamine (Reminyl).

    abstract：:Vascular dementia (VaD) has a great deal of overlap (in terms of features and symptoms) with Alzheimer's disease (AD). Mixed dementia, or AD with concomitant cerebrovascular disease (AD with CVD), is increasingly being recognized as a distinct clinical condition that occurs with substantial frequency. The robust evide...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00267-8

    authors： Erkinjuntti T

    更新日期：2002-11-15 00:00:00

  • Progression in multiple sclerosis: further evidence of an age dependent process.

    abstract：:The relapsing-remitting phase and the progressive phase of multiple sclerosis (MS) seem to be the result of distinct pathophysiological processes. Previous research on the natural history of MS was largely focussed on relapses and disability scores. In this study we evaluated 438 patients with secondary or primary pro...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.01.067

    authors： Koch M,Mostert J,Heersema D,De Keyser J

    更新日期：2007-04-15 00:00:00

  • Association of ankle-brachial index level with stroke.

    abstract：BACKGROUND:There are conflicting data on the relationship between peripheral arterial disease (PAD) as defined by an ankle-brachial index (ABI) of <0.9 and stroke risk, and these prior data have largely focused on a single race or gender. Furthermore, the association between subsequent ABIs above the established 0.9 th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.08.016

    authors： Ovbiagele B

    更新日期：2009-01-15 00:00:00

  • CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia.

    abstract：:The in vivo diagnosis of Alzheimer's disease (AD) may be facilitated by cerebro-spinal fluid (CSF) biomarkers in combination with imaging and clinical assessments. By determining the concentration of beta amyloid fragments, total tau (t-tau) and phospho-tau (p-tau), it is possible to detect the conversion of mild cogn...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.02.343

    authors： Stefani A,Sancesario G,Pierantozzi M,Leone G,Galati S,Hainsworth AH,Diomedi M

    更新日期：2009-08-15 00:00:00

  • The concept of vascular cognitive impairment.

    abstract：:Vascular dementia (VaD) is increasingly recognised to reflect an outmoded concept in that it identifies cases too late for preventive therapy to have an opportunity to prevent the development of dementia and uses a cognitive paradigm inappropriately based on Alzheimer's disease. A replacement is urgently required and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00253-8

    authors： Bowler JV

    更新日期：2002-11-15 00:00:00