当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Androgen receptor mRNA with increased size of tandem CAG repeat is widely expressed in the neural and nonneural tissues of X-linked recessive bulbospinal neuronopathy.

Androgen receptor mRNA with increased size of tandem CAG repeat is widely expressed in the neural and nonneural tissues of X-linked recessive bulbospinal neuronopathy.

Abstract：

:We detected androgen receptor (AR) mRNA expression in various tissues in the patients with X-BSNP and controls using reverse transcription polymerase chain reaction (RT-PCR) and Northern blot analysis. The AR mRNAs were expressed in a wide variety of tissues including the testis, scrotal skin, liver, skeletal and cardiac muscles, sciatic nerve, sympathetic and dorsal root ganglia and spinal cord, and were all abnormally elongated in the size of the CAG repeat in the patients. The mutant AR gene with increased size of tandem CAG repeat was directly transcribed in various tissues, and would be related to a wide spectrum of phenotypic manifestations in X-BSNP.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Doyu M,Sobue G,Kimata K,Yamamoto K,Mitsuma T

doi

10.1016/0022-510x(94)90133-3

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

43-7

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(94)90133-3

journal_volume

127

pub_type

杂志文章

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