当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

Abstract：

:Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humoral factors in sera from PD patients could inhibit cell dopaminergic activity, the aim of this study was to determine whether a plasma circulating factor from PD patients could modify *NO metabolism in PMN from healthy control subjects. To this purpose, we determined simultaneously the maximal production rate of *NO and hydrogen peroxide (H2O2) of PMA-activated PMN isolated from healthy control subjects in the presence of aliquots of plasma of PD patients. The results showed that, after 30 min incubation, plasma from newly diagnosed (n=4) or from L-Dopa chronically treated (n=7) PD patients enhanced *NO release in neutrophils isolated from healthy controls by about 50% and 47% respectively, with respect to non-parkinsonian control plasma (n = 10); in the same condition, H2O2 production did not differ among the groups. These data suggest that an overproduction of *NO related to plasma circulating factors, already detected at initial stages of the disease, participates in the pathophysiology of Parkinson's disease.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

doi

10.1016/s0022-510x(99)00079-9

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

66-70

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(99)00079-9

journal_volume

165

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Early intervention with immunomodulatory agents in the treatment of multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a lifelong neurologic disease leading to moderate or severe disability in the majority of affected patients. Studies of the natural history of MS suggest that 90% of patients with relapsing-remitting MS eventually develop secondary progressive (SP) disease. Magnetic resonance imaging (MRI) s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(02)00039-4

    authors： Jeffery DR

    更新日期：2002-05-15 00:00:00

  • Acute ischaemic neuropathy in the rabbit.

    abstract：:Ligation of either the common and internal iliac or the internal and external iliac arteries produced ischaemic lesions of the sciatic nerve and its branches, as well as direct muscle damage, in 5 out of 6 rabbits. In one animal, ligation of the aorta and of the internal iliac artery on one side produced a similar mix...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90220-x

    authors： Hess K,Eames RA,Darveniza P,Gilliatt RW

    更新日期：1979-12-01 00:00:00

  • Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.

    abstract：:The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identifie...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2009.09.009

    authors： Palace J

    更新日期：2009-11-15 00:00:00

  • Seasonal variations of 25-OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients.

    abstract：:Low 25-hydroxy vitamin D (25-[OH]-D) serum concentrations have been associated with higher disease activity in multiple sclerosis (MS) patients. In a large cross-sectional study we assessed the vitamin D status in MS patients in relation to seasonality and relapse rate. 415 MS-patients (355 relapsing-remitting MS and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.01.059

    authors： Hartl C,Obermeier V,Gerdes LA,Brügel M,von Kries R,Kümpfel T

    更新日期：2017-04-15 00:00:00

  • Videofluoroscopic assessment of swallowing function in patients with myasthenia gravis.

    abstract：:Swallowing function in myasthenia gravis (MG) was investigated by videofluoroscopy (VF). A total of 23 VF examinations were performed on 11 MG patients at various time points over the exacerbation and remission stages of disease. The assessment parameters on VF examination are set as follows: bolus transport from the ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.12.007

    authors： Higo R,Nito T,Tayama N

    更新日期：2005-04-15 00:00:00

  • Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.

    abstract：:Pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS), is an autosomal recessive neurodegenerative disorder characterized by iron accumulation in the brain. Mutations in the pantothenate kinase 2 (PANK2) gene are known to be responsible for PKAN. Several studies h...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.11.008

    authors： Doi H,Koyano S,Miyatake S,Matsumoto N,Kameda T,Tomita A,Miyaji Y,Suzuki Y,Sawaishi Y,Kuroiwa Y

    更新日期：2010-03-15 00:00:00

  • Late onset cerebello-pontomesencephalic degeneration.

    abstract：:Two siblings are presented with late onset, rapidly progressive truncal ataxia, paralysis of down-gaze and loss of up-gaze saccades in association with other oculomotor dysfunctions as well as dementia. Electron microscopic muscle studies revealed abnormal distribution and form of the mitochondria, probably being the ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90202-5

    authors： al-Din AS,al-Zuhair AG,al-Salem MK,al-Nassar KE,Rudwan MA,Khafaja S,Hamawi T

    更新日期：1989-11-01 00:00:00

  • Contraction tension and kinetics of the peroneus longus muscle in golden retriever muscular dystrophy.

    abstract：:Contraction tension and kinetics of the peroneus longus muscle were studied in dogs with the Duchenne homologue, golden retriever muscular dystrophy (GRMD), in advance of evaluating localized therapies such as myoblast transplantation. Absolute and both muscle- and body-weight-corrected twitch tension in GRMD dogs wer...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90210-0

    authors： Kornegay JN,Sharp NJ,Bogan DJ,Van Camp SD,Metcalf JR,Schueler RO

    更新日期：1994-05-01 00:00:00

  • Safety and pharmacodynamics of a novel recombinant botulinum toxin E (rBoNT-E): Results of a phase 1 study in healthy male subjects compared with abobotulinumtoxinA (Dysport®).

    abstract：:Naturally occurring botulinum toxin (BoNT) serotypes have different pharmacological features of therapeutic and aesthetic interest. This phase 1, double-blind, placebo-controlled study (EudraCT: 2016-002609-20) assessed safety, tolerability and pharmacodynamics (PD) of the first recombinant BoNT serotype E (rBoNT-E) v...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jns.2019.116516

    authors： Pons L,Vilain C,Volteau M,Picaut P

    更新日期：2019-12-15 00:00:00

  • Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1.

    abstract：:Charcot-Marie-Tooth disease type 1 (CMT1) is a heterogeneous disorder. Most CMT1 patients are associated with a duplication of 17p11.2-p12 (CMT1A duplication), but a small number of patients have mutations of peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ), connexin 32 (Cx32) and early growth response ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(03)00028-5

    authors： Numakura C,Shirahata E,Yamashita S,Kanai M,Kijima K,Matsuki T,Hayasaka K

    更新日期：2003-06-15 00:00:00

  • Greater intraprocedural systolic blood pressure and blood pressure variability are associated with contrast-induced neurotoxicity after neurointerventional procedures.

    abstract：BACKGROUND:Contrast-induced neurotoxicity (CIN) is a rare complication of neurointerventional procedures and its understanding remains limited. We evaluated the association of CIN with systemic hemodynamics in patients undergoing neuroendovascular interventions. METHODS:We conducted a 1:2 matched case-control study fr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.117209

    authors： Zevallos CB,Dai B,Dandapat S,Quispe-Orozco D,Holcombe A,Ansari S,Farooqui M,Derdeyn CP,Samaniego EA,Ortega-Gutierrez S

    更新日期：2021-01-15 00:00:00

  • Comparison of major cortical aminopeptidase activity in normal brain and brain from patients with Alzheimer's disease.

    abstract：:In order to develop a greater understanding of the importance of peptide catabolism in the intracellular protein degradation process in normal and pathological human brain, we have undertaken a systematic investigation of the aminopeptidase group of enzymes. Although a wide range of aminoacyl-7-amino-4-methylcoumarin ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90024-5

    authors： Mantle D,Lauffart B,Perry EK,Perry RH

    更新日期：1989-02-01 00:00:00

  • IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease.

    abstract：:The production of interleukin-2 (IL-2) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (MNC) was assessed in patients with Alzheimer's disease (AD) who were subdivided into two groups--mild and moderately-severe--according to the severity of the disease, probable vascular dementia (VaD) patients and eld...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/0022-510x(95)00016-u

    authors： Huberman M,Sredni B,Stern L,Kott E,Shalit F

    更新日期：1995-06-01 00:00:00

  • Duchenne muscular dystrophy: do both parents contribute genetically to the disease?

    abstract：:By observing the effect of 0.08 and 0.02 mg/ml linoleic acid (LA on the electrophoretic mobility of fresh red blood cells derived from the parents of a subject with DMD, it has been shown that all of 16 fathers as well as 15 mothers, consistently differ from normal. In normal subjects, whilst 0.08 mg/ml LA causes incr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(87)90021-9

    authors： Field EJ,Joyce G

    更新日期：1987-12-01 00:00:00

  • Association of ankle-brachial index level with stroke.

    abstract：BACKGROUND:There are conflicting data on the relationship between peripheral arterial disease (PAD) as defined by an ankle-brachial index (ABI) of <0.9 and stroke risk, and these prior data have largely focused on a single race or gender. Furthermore, the association between subsequent ABIs above the established 0.9 th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.08.016

    authors： Ovbiagele B

    更新日期：2009-01-15 00:00:00

  • Aberrant androgen action and increased size of tandem CAG repeat in androgen receptor gene in X-linked recessive bulbospinal neuronopathy.

    abstract：:Plasma levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) after 3 or 6 days of administration of the synthetic androgenic hormone fluoxymesterone (10 mg/day) were measured in 26 patients with X-linked recessive bulbospinal neuronopathy (X-BSNP) and 22 age-matched male controls. The...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90347-6

    authors： Sobue G,Doyu M,Morishima T,Mukai E,Yasuda T,Kachi T,Mitsuma T

    更新日期：1994-02-01 00:00:00

  • Benign intracranial hypertension. A retrospective and follow-up study.

    abstract：:Thirty-six patients with benign intracranial hypertension (BIH) were reviewed. Follow-up was obtained on 33 patients (91%) after a mean period of 7 1/2 years. Precipitating factors were found in 27 patients (75%). On admission, 5 patients had retro-ocular pain, especially on eye movements, a complaint not yet describe...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90200-4

    authors： Bulens C,De Vries WA,Van Crevel H

    更新日期：1979-02-01 00:00:00

  • Discrete lesions in the sensorimotor control system. A clinical-topographical study of lacunar infarcts.

    abstract：:In 50 patients with computed tomography-verified small, deep, lacunar, infarcts from a prospective stroke registry, we studied the lesion site in relationship with the clinical syndromes pure motor stroke, sensorimotor stroke and ataxic hemiparesis. Seventy per cent (95% confidence interval: 57-83%) of the lesions wer...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90138-w

    authors： Boiten J,Lodder J

    更新日期：1991-10-01 00:00:00

  • Olfactory function and neuropsychological profile to differentiate dementia with Lewy bodies from Alzheimer's disease in patients with mild cognitive impairment: A 5-year follow-up study.

    abstract：BACKGROUND:Mild cognitive impairment (MCI) is a well-known precursor of Alzheimer's disease (AD) but often also precedes dementia with Lewy bodies (DLB). The early differentiation of DLB from AD is important to delay disease progression. Olfactory dysfunction is a well-known early sign of both AD and Lewy body disorder...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.06.013

    authors： Yoon JH,Kim M,Moon SY,Yong SW,Hong JM

    更新日期：2015-08-15 00:00:00

  • Roentgenmorphological aspects of muscular pseudohypertrophy.

    abstract：:Using special soft tissue X-ray investigations the authors have found that the increase in volume of the calf musculature in progressive muscular dystrophy does not seem to be in complete accordance with the criteria of pseudohypertrophy. It has been demonstrated that this structural alteration of the musculature does...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90074-1

    authors： Pálvölgyi R,Gallai M

    更新日期：1979-09-01 00:00:00

  • Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis.

    abstract：BACKGROUND AND OBJECTIVE:Multiple sclerosis (MS) has been consistently associated with the HLA-DR2 haplotype and particularly with the HLA-DRB1*15 allele. Epistatic interactions between both parental alleles in the DRB1 loci have been shown to modify the MS susceptibility risk. This study investigated the frequencies o...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.07.026

    authors： Romero-Pinel L,Pujal JM,Martínez-Yélamos S,Gubieras L,Matas E,Bau L,Torrabadella M,Azqueta C,Arbizu T

    更新日期：2010-11-15 00:00:00

  • Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship.

    abstract：:In this study, we investigated the dose-effect relationship and safety of tissue plasminogen activator (tPA) for the treatment of intraventricular hemorrhage/hematoma (IVH) in rats. Adult male Sprague-Dawley rats were injected with autologous blood into the left lateral ventricle to establish IVH. Two hours later, Rin...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00243-5

    authors： Wang YC,Lin CW,Shen CC,Lai SC,Kuo JS

    更新日期：2002-10-15 00:00:00

  • Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity.

    abstract：OBJECTIVE:To report the first histopathologic description of optic nerve demyelination from tacrolimus (FK 506) toxicity in the absence of toxic levels of tacrolimus in a patient presenting with asymmetric bilateral visual loss after 5 years of tacrolimus therapy. PATIENTS:We report a patient status post cardiac and r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.10.014

    authors： Venneti S,Moss HE,Levin MH,Vagefi MR,Brozena SC,Pruitt AA,Mourelatos Z,Trojanowski JQ,Galetta SL,Balcer LJ

    更新日期：2011-02-15 00:00:00

  • Right proatlantal artery type I, right internal carotid occlusion, and left internal carotid stenosis: case report and review of the literature.

    abstract：:A 66-year-old man presented with right cerebellar infarction and ischemic lesions in the left dorsal thalamus and right upper parietal lobe. Angiography showed occlusion of the right internal carotid artery proximal to an ipsilateral proatlantal artery type I, 70% stenosis of the left internal carotid artery, and apla...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0022-510x(93)90178-2

    authors： Kolbinger R,Heindel W,Pawlik G,Erasmi-Körber H

    更新日期：1993-07-01 00:00:00

  • HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression.

    abstract：OBJECTIVE:HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.10.030

    authors： Matsuura E,Nozuma S,Tashiro Y,Kubota R,Izumo S,Takashima H

    更新日期：2016-12-15 00:00:00

  • Changes in cerebral blood flow velocity after treatment with sumatriptan or placebo and implications for the pathophysiology of migraine.

    abstract：:Whether the primary mechanisms of migraine are vascular or neurogenic is, as yet, unresolved. In humans it is still unclear whether sumatriptan acts via constriction of dilated arteries or through other mechanisms. Doppler sonography is a non-invasive method for measuring blood flow velocities (BFV), an indirect marke...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0022-510x(95)00344-2

    authors： Limmroth V,May A,Auerbach P,Wosnitza G,Eppe T,Diener HC

    更新日期：1996-06-01 00:00:00

  • Parabiotic reinnervation in normal and dystrophic mice. Part 1. Muscle weight and physiological studies.

    abstract：:A technique called parabiotic reinnervation has been developed. This technique consisted of suturing the sectioned peripheral end of the common peroneal nerve of a normal mouse, strain 129 ReJ +/+ to that of the distal stump remaining after sectioning that same nerve in a dystrophic mouse, strain 129 ReJ dy/dy. The an...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(75)90211-7

    authors： Montgomery A

    更新日期：1975-11-01 00:00:00

  • Utility of auditory P300 in detection of presenile dementia.

    abstract：:The significance of P300 in investigation of the cognitive changes characteristic of aging and dementia is well established. But some controversies about sensitivity and specificity of P300 latency prolongation in detection of dementia still exist, and its predictive value and specificity in "real" clinical situations...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0022-510x(95)00093-h

    authors： Filipović SR,Kostić VS

    更新日期：1995-08-01 00:00:00

  • Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: an amplitude of low-frequency fluctuation study.

    abstract：PURPOSE:To investigate localized cerebral function abnormalities in patients with familial cortical myoclonic tremor and epilepsy (FCMTE) using resting-state functional magnetic resonance imaging (fMRI). METHODS:Seven patients with FCMTE from a Chinese family, seven patients with essential tremor (ET), and ten healthy...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.03.005

    authors： Wang P,Luo C,Dong L,Bin Y,Ma S,Yao D,Guo F,Yang Z

    更新日期：2015-04-15 00:00:00

  • More than hemifacial spasm? A case of unilateral facial spasms with systematic review of red flags.

    abstract：:Unilateral facial spasms (UFS) are frequently caused by hemifacial spasm (HFS), a disorder that usually results from vascular loop compression at the root exit zone of the facial nerve. However, UFS can also be a manifestation of other conditions, including brainstem tumours or demyelination, post-Bell's synkinesis, l...

    journal_title：Journal of the neurological sciences

    pub_type： 信件

    doi：10.1016/j.jns.2019.116532

    authors： Sringean J,Dressler D,Bhidayasiri R

    更新日期：2019-12-15 00:00:00