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Nonhomogeneous distribution of 5-hydroxyindoleacetic acid and homovanillic acid in the lumbar cerebrospinal fluid of man.

Abstract：

:The volume of the lumbar sac measured in 4 subjects was found to be 15.5 ml. Exactly 15 ml of lumbar cerebrospinal fluid (L-CSF) was permitted to flow freely out during a lumbar puncture in 20 neurological patients and small samples of the L-CSF were collected in the beginning (sample 1), at the middle (sample 2), and at the end (sample 3) of this procedure either for 5-HIAA or HVA measurement. The concentrations of 5-HIAA and HVA increased in an exponential manner from sample 1 to sample 3. These results indicate that CSF in the lumbar sac is not a homogeneous fluid as is generally believed and that certain rules have to be followed in the sampling of the L-CSF to obtain reproducible biochemical data.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Jakupcević M,Lacković Z,Stefoski D,Bulat M

doi

10.1016/0022-510x(77)90103-4

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

165-71

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(77)90103-4

journal_volume

31

pub_type

杂志文章

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