当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Antibodies against myelin oligodendrocyte glycoprotein in the cerebrospinal fluid of multiple sclerosis patients.

Antibodies against myelin oligodendrocyte glycoprotein in the cerebrospinal fluid of multiple sclerosis patients.

Abstract：

:Antibodies against myelin oligodendrocyte glycoprotein (MOG) mediate demyelination in experimental autoimmune encephalomyelitis (EAE) in different animal species and are implicated in the immunopathogenesis of multiple sclerosis (MS). In order to evaluate the anti-MOG response, we have analyzed the cerebrospinal fluids (CSFs) from 44 MS patients and 51 controls, 11 with other inflammatory neurological disorders (OIND) and 40 with non-inflammatory neurological disorders (NIND). The frequency of anti-MOG antibodies positive patients in the MS group (30%) was significantly higher compared to the NIND (8%, p=0.02), but not compared to the OIND group (55%, p=0.228). Interestingly, all six patients with neurosarcoidosis had MOG-specific antibodies in their CSF. Frequency of anti-MOG antibodies was similar in patients with clinically active and stable MS (32% and 26%, respectively; p=0.921). However, in clinically active MS patients, antibody titers were higher in comparison with patients with stable disease, although the difference did not reach the level of statistical significance (p=0.06). These results further support the potential role of anti-MOG antibodies in the immunopathology of MS in the subset of patients with this disease. Furthermore, our findings suggest for the first time that anti-MOG antibodies could be an accessory diagnostic tool in neurosarcoidosis.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Markovic M,Trajkovic V,Drulovic J,Mesaros S,Stojsavljevic N,Dujmovic I,Mostarica Stojkovic M

doi

10.1016/s0022-510x(03)00066-2

subject

Has Abstract

pub_date

2003-07-15 00:00:00

pages

67-73

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022510X03000662

journal_volume

211

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash.

    abstract：:We describe a 54-year-old diabetic woman who developed ischemic optic neuropathy followed by acute retinal necrosis and multiple areas of focal venous beading. Vitreous fluid contained amplifiable VZV DNA but not HSV-1, CMV or toxoplasma DNA. The clinical presentation was remarkable for jaw claudication and intermitte...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.12.021

    authors： Mathias M,Nagel MA,Khmeleva N,Boyer PJ,Choe A,Durairaj VD,Bennett JL,Mandava N,Gilden D

    更新日期：2013-02-15 00:00:00

  • Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.

    abstract：:Myotonic Dystrophy Type 1 (DM1) in combination with demyelinating neuropathy is very rare in literature. In this study, DM1 and demyelinating neuropathy were demonstrated clinically and electromyographically in a 43-year-old female patient from Turkey. In the patient an expanded CTG repeat in the Myotonic Dystrophy Pr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.09.028

    authors： Kurt S,Karaer H,Kaplan Y,Akat I,Battaloglu E,Eruslu D,Basak AN

    更新日期：2010-01-15 00:00:00

  • Effects of castration, testosterone and immobilization on the activities of choline acetyltransferase and cholinesterase in rat limb muscles.

    abstract：:Thirteen months after castration of male rats the weight of their soleus muscles was lowered to 82% and their choline acetyltransferase (ChAc) activity to 83% of control values. The administration of testosterone lasting 5 weeks increased the weight of the soleus muscles of castrated animals by 19% and their ChAc acti...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(76)90008-3

    authors： Tucek S,Kŏstírová D,Gutmann E

    更新日期：1976-03-01 00:00:00

  • Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: a functional MRI study.

    abstract：BACKGROUND:The evidence suggests that the origin of primary dystonia is at least partly associated with widespread dysfunction of the basal ganglia and cortico-striato-thalamo-cortical circuits. The aim of the study was to assess the sensorimotor activation pattern outside the circuits controlling the affected body par...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jns.2011.03.040

    authors： Opavský R,Hluštík P,Otruba P,Kaňovský P

    更新日期：2011-07-15 00:00:00

  • Accuracy of CSF and MRI criteria for dissemination in space in the diagnosis of multiple sclerosis.

    abstract：:Demonstration of lesion dissemination in space (DIS) and time (DIT) is necessary for the diagnosis of multiple sclerosis (MS) in clinically isolated syndromes (CIS). The McDonald criteria accepted two methods to demonstrate DIS. The fulfillment of at least three of four MRI Barkhof criteria (MRI-BC) or, alternatively,...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.08.030

    authors： Villar LM,García-Barragán N,Sádaba MC,Espiño M,Gómez-Rial J,Martínez-San Millán J,González-Porqué P,Alvarez-Cermeño JC

    更新日期：2008-03-15 00:00:00

  • A fatal congenital myopathy with severe type I fibre atrophy, central nuclei and multicores.

    abstract：:An unusual fatal congenital myopathy in a Chinese female infant is described. Muscle biopsy showed type I fibre smallness with central nuclei and focal decrease in oxidative enzyme activities affecting mainly larger type II fibres. Longitudinal sections from glutaldehyde-fixed araldite-embedded material stained with t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90173-8

    authors： Lee YS,Yip WC

    更新日期：1981-05-01 00:00:00

  • Early-onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.

    abstract：:Familial hemiplegic migraine type 1, spinocerebellar ataxia type 6 (SCA6) and episodic ataxia type 2 (EA2) are allelic disorders associated with mutations in the CACNA1A gene, which encodes the alpha1 subunit of the P/Q-type calcium channel (Ca(V)2.1). SCA6 and EA2 share a number of clinical features, such as prominen...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.01.008

    authors： Cricchi F,Di Lorenzo C,Grieco GS,Rengo C,Cardinale A,Racaniello M,Santorelli FM,Nappi G,Pierelli F,Casali C

    更新日期：2007-03-15 00:00:00

  • Neuropathology of sporadic amyotrophic lateral sclerosis of long duration.

    abstract：:We performed post-mortem examinations of three patients with progressive neurogenic amyotrophy of long duration. One patient had been clinically diagnosed as having sporadic amyotrophic lateral sclerosis (ALS) and two had been diagnosed with progressive spinal muscular atrophy (PSMA). The disease durations were 10, 17...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)00297-3

    authors： Iwanaga K,Hayashi S,Oyake M,Horikawa Y,Hayashi T,Wakabayashi M,Kondo H,Tsuji S,Takahashi H

    更新日期：1997-03-10 00:00:00

  • Preimplantation factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model.

    abstract：INTRODUCTION:Embryo-derived PIF modulates systemic maternal immunity without suppression. Synthetic analog (sPIF) prevents juvenile diabetes, preserves islet function, reducing oxidative stress/protein misfolding. We investigate sPIF effectiveness in controlling neuroinflammation/MS. METHODS:Examine sPIF-induced prote...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.07.050

    authors： Weiss L,Or R,Jones RC,Amunugama R,JeBailey L,Ramu S,Bernstein SA,Yekhtin Z,Almogi-Hazan O,Shainer R,Reibstein I,Vortmeyer AO,Paidas MJ,Zeira M,Slavin S,Barnea ER

    更新日期：2012-01-15 00:00:00

  • Abnormal apocrine secretory cell mitochondria in a Huntington disease patient.

    abstract：:Over two decades, a 42-year old woman experienced the gradual onset of choreic involuntary movements, dystonia, and tics. Decreased caudate nucleus metabolism on 2-deoxyglucose PET scan and a heterozygous 49-CAG repeat expansion within the HTT gene established the diagnosis of HD, although no other family history was ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.08.034

    authors： Sidiropoulos C,LeWitt P,Hashimoto K

    更新日期：2012-12-15 00:00:00

  • Reduced adhesiveness between skin fibroblasts from patients with Duchenne muscular dystrophy.

    abstract：:The intercellular adhesiveness of skin fibroblasts from patients with Duchenne muscular dystrophy and normal controls has been measured by determining the collision efficencies of cells using the couette viscometer. The collision efficencies for dystrophic cells were significantly lower that those for normal cells (0....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90025-x

    authors： Jones GE,Witkowski JA

    更新日期：1979-11-01 00:00:00

  • Spinocerebellar ataxia type 6: founder effect in Western Japan.

    abstract：:An accumulation of SCA6 cases has been observed in the Chugoku area of Western Japan. In the Tottori prefecture, located in the northeastern part of the Chugoku district, we observed a cluster of SCA6 families within the eastern area, suggesting that there may be a founder in the Japanese SCA6 population. Genotyping w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00453-1

    authors： Mori M,Adachi Y,Kusumi M,Nakashima K

    更新日期：2001-03-15 00:00:00

  • High-dose, frequently administered interferon beta therapy for relapsing-remitting multiple sclerosis must be maintained over the long term: the interferon beta dose-reduction study.

    abstract：:Long-term trials have demonstrated the continued efficacy of interferon (IFN) beta treatment in patients with relapsing-remitting (RR) multiple sclerosis (MS) during prolonged administration. The objective of the work was to evaluate the effects of reducing IFN beta administration frequency and total weekly dose in pa...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jns.2004.03.023

    authors： Barbero P,Verdun E,Bergui M,Pipieri A,Clerico M,Cucci A,Ricci A,Bergamasco B,Durelli L

    更新日期：2004-07-15 00:00:00

  • Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat.

    abstract：:Recently, the beneficial role of minocycline on endogenous neurogenesis after cerebral ischemia has been contradicted by many reports. We examined whether minocycline influences post-ischemic neurogenesis in the subventricular zone. Adult male Sprague-Dawley rats were subjected to focal cerebral ischemia for 2 h, and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.12.025

    authors： Kim BJ,Kim MJ,Park JM,Lee SH,Kim YJ,Ryu S,Kim YH,Yoon BW

    更新日期：2009-04-15 00:00:00

  • Intravascular lymphomatosis presenting with sudden hearing loss.

    abstract：:Intravascular lymphoma (IVL) is a rare disorder characterized by the aggregation of malignant large cell lymphoma cells in small vessels. Neurological manifestations are typically the initial and, often the only, clinically obvious consequences of this malignancy. Diagnosis is dependent on biopsy or postmortem demonst...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2005.01.001

    authors： Berger JR,Jones R,Wilson D

    更新日期：2005-05-15 00:00:00

  • Novel drug development for amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) has become an increasingly attractive area for the pharmaceutical industry, the most experimentally tractable of the neurodegenerative diseases. Mechanisms underlying cell death in ALS are likely to be important in more common but more complex disorders. Riluzole, the only drug laun...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(00)00419-6

    authors： Hurko O,Walsh FS

    更新日期：2000-11-01 00:00:00

  • Invalidation of Parkinson's disease diagnosis after years of follow-up based on clinical, radiological and neurophysiological examination.

    abstract：INTRODUCTION:Diagnosis of Parkinson's disease (PD) is mainly based on clinical features. Accurate neurological examination is required but dopamine transporter (DaT) single photon emission computed tomography (SPECT) could be perfomed to support the diagnosis in ambiguous cases. The aim of this work is to describe the ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116454

    authors： Coarelli G,Garcin B,Roze E,Vidailhet M,Degos B

    更新日期：2019-11-15 00:00:00

  • Multiple cerebral infarctions in a young patient with heroin-induced hypereosinophilic syndrome.

    abstract：:Hypereosinophilic syndrome represents a rare cause for cerebral infarctions and inflammatory neurological disorders. Various possible pathogenic mechanisms for cerebral infarctions have already been discussed. Complex mechanisms including a local hypercoagulability by eosinophilic granules as well as a direct damage t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.06.031

    authors： Bolz J,Meves SH,Kara K,Reinacher-Schick A,Gold R,Krogias C

    更新日期：2015-09-15 00:00:00

  • Anhedonia and its correlation with clinical aspects in Parkinson's disease.

    abstract：:Anhedonia is one of the non-motor symptoms observed in the Parkinson's disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relati...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2016.10.051

    authors： Nagayama H,Maeda T,Uchiyama T,Hashimoto M,Nomoto N,Kano O,Takahashi T,Terashi H,Hamada S,Hasegawa T,Hatano T,Takahashi T,Baba Y,Sengoku R,Watanabe H,Inoue M,Kadowaki T,Kaneko S,Shimura H,Kubo SI,Young Japanese Exp

    更新日期：2017-01-15 00:00:00

  • Paraneoplastic neurological syndromes in lung cancer patients with or without onconeural antibodies.

    abstract：BACKGROUND:Paraneoplastic neurological syndromes (PNS) are poorly described in patients without onconeural antibodies and in patients with non-small cell lung cancer (NSCLC). We compared the clinical characteristics of PNS in lung cancer patients with and without onconeural antibodies. METHODS:Medical records from pat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.10.040

    authors： Raspotnig M,Vedeler C,Storstein A

    更新日期：2015-01-15 00:00:00

  • Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis.

    abstract：:In recent years it has become clear that multiple sclerosis (MS) patients benefit from physical exercise as performed in aerobic training but little is known about the effect on functional domains and physiological factors mediating these effects. We studied immunological, endocrine and neurotrophic factors as well as...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jns.2004.06.009

    authors： Schulz KH,Gold SM,Witte J,Bartsch K,Lang UE,Hellweg R,Reer R,Braumann KM,Heesen C

    更新日期：2004-10-15 00:00:00

  • Correlation between the capacity of bacterial lipopolysaccharide to supress experimental allergic encephalomyelitis and its mitogenic activity for lymph node cells in guinea pigs.

    abstract：:Protection of guinea pigs from experimental allergic encephalomyelitis (EAE) was attempted using bacterial lipopolysaccharide (LPS) from 4 sources. The ability of these LPS to induce DNA synthesis in guinea pig lymph node (LN) cells in vitro was also investigated. It was found that there existed a good correlation bet...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90174-6

    authors： Nagasawa K,Mori R,Kondo S,Hisatsune K

    更新日期：1979-08-01 00:00:00

  • Zolpidem-induced sleep-related eating disorder.

    abstract：:An association between zolpidem administration and sleep-related eating disorder (SRED) has been suggested. The authors observed zolpidem-induced SRED in restless legs syndrome (RLS). With the review of previous reports, we identified a common occurrence of RLS in zolpidem-induced SRED. ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.09.026

    authors： Yun CH,Ji KH

    更新日期：2010-01-15 00:00:00

  • Metallothionein in Menkes' disease: induction in cultured muscle cells.

    abstract：:Menkes' disease is an inherited disturbance of copper metabolism. Addition of copper to the medium of cultured fibroblasts and lymphoblasts from patients with Menkes' disease results in an increased induction of metallothionein. We investigated the metallothionein induction in response to copper and zinc in muscle cel...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90012-c

    authors： Herzberg NH,Wolterman RA,van den Berg GJ,Barth PG,Bolhuis PA

    更新日期：1990-12-01 00:00:00

  • Myasthenia due to carnitine treatment.

    abstract：:Severe weakness of lower cranial and girdle muscles has been found in 4 subjects among 20 dialysis patients treated with carnitine in order to correct their high plasma triglyceride level. Neurophysiological investigation showed an impairment of neuromuscular transmission with short-term reduction of evoked muscle res...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90061-1

    authors： De Grandis D,Mezzina C,Fiaschi A,Pinelli P,Bazzato G,Morachiello M

    更新日期：1980-06-01 00:00:00

  • Susceptibility of human skeletal muscle culture to influenza virus infection. Part 2. Ultrastructural cytopathology.

    abstract：:Cultured post-fused human skeletal muscle monolayers exposed to WSN influenza A virus were analyzed by scanning and transmission electron microscopy. At 12-14h post-inoculation (p.i.), affected mononuclear cells retracted from the cell surface, but remained anchored to the substrate by taut filar processes. Retraction...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90162-4

    authors： Miranda AF,Gamboa ET,Armstrong CL,Hsu KC

    更新日期：1978-03-01 00:00:00

  • Advances in vasospasm treatment and prevention.

    abstract：:Outcome after aSAH depends on several factors, including the severity of the initial event, perioperative medical management, surgical variables, and the incidence of complications. Cerebral vasospasm (CV) is ure to consistently respond to treatment, emphasizing the need for further research into the underlying mechan...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2007.04.046

    authors： Komotar RJ,Zacharia BE,Valhora R,Mocco J,Connolly ES Jr

    更新日期：2007-10-15 00:00:00

  • Anosmia is associated with lower in-hospital mortality in COVID-19.

    abstract：BACKGROUND:Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We analysed whether anosmia predicts in-hospital mortality; and if patients with anosmia have a different clinical presentation, inflammatory response, or disease severity. METHODS:Retrospective cohort study including all...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.117163

    authors： Talavera B,García-Azorín D,Martínez-Pías E,Trigo J,Hernández-Pérez I,Valle-Peñacoba G,Simón-Campo P,de Lera M,Chavarría-Miranda A,López-Sanz C,Gutiérrez-Sánchez M,Martínez-Velasco E,Pedraza M,Sierra Á,Gómez-Vicente B,Guerre

    更新日期：2020-12-15 00:00:00

  • Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese.

    abstract：BACKGROUND:Ischemic stroke is the end phenotype of a complex interaction between various genetic and environmental factors. OBJECTIVE:We aimed to explore association of two lipid-relevant genetic variants and conventional risk factors with risk of having ischemic stroke in Northern Han Chinese. METHODS:Genotyping was...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.09.013

    authors： Wang B,Zhao H,Zhou L,Dai X,Wang D,Cao J,Niu W

    更新日期：2009-01-15 00:00:00

  • Cardiac transplantation in Friedreich Ataxia: Extended follow-up.

    abstract：:Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder most commonly caused by guanine-adenine-adenine (GAA) trinucleotide repeat expansions in both alleles of the FXN gene. Although progressive ataxia remains the hallmark clinical feature, patients with FRDA are at high risk of developing cardi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.01.027

    authors： McCormick A,Shinnick J,Schadt K,Rodriguez R,Addonizio L,Hirano M,Perlman S,Lin KY,Lynch DR

    更新日期：2017-04-15 00:00:00