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Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat.

Abstract：

:Recently, the beneficial role of minocycline on endogenous neurogenesis after cerebral ischemia has been contradicted by many reports. We examined whether minocycline influences post-ischemic neurogenesis in the subventricular zone. Adult male Sprague-Dawley rats were subjected to focal cerebral ischemia for 2 h, and divided into a minocycline-treated (90 mg/Kg on reperfusion and 45 mg/Kg daily for maintenance) and a saline-treated group. Bromodeoxyuridine was injected to determine levels of cell proliferation. Inflammation was assessed by counting polymorphonuclear cell and activated microglia and by measuring myeloperoxidase activity. Endogenous neurogenesis was quantified by immunohistochemical staining and functional outcome was measured by infarct size and behavioral tests. Minocycline treatment decreased inflammation on 1st and 4th days after ischemia. BrdU-positive cells on 7th day (saline vs. minocycline: 602.80+/-146.96 vs. 399.40+/-109.69) and the number of double labeling cells of BrdU/NeuN on 7th day (13.00+/-4.36 vs. 6.40+/-2.07) and BrdU/DCx on 4th day (17.00+/-5.00 vs. 7.50+/-1.91) were significantly decreased in minocycline-treated rats. Infarct size and behavioral tests were not different. Our results indicate that minocycline may reduce immediate post-ischemic neurogenesis despite adequately suppressed inflammation.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Kim BJ,Kim MJ,Park JM,Lee SH,Kim YJ,Ryu S,Kim YH,Yoon BW

doi

10.1016/j.jns.2008.12.025

subject

Has Abstract

pub_date

2009-04-15 00:00:00

pages

70-5

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(08)00607-2

journal_volume

279

pub_type

杂志文章

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