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Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy.

Abstract：

:There is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-HT receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. We describe two sisters with hemiplegic migraine, low CSF and platelet serotonin levels, and progressive spastic paraparesis associated with profound spinal cord atrophy whose lower extremity strength and ambulation responded to a precursor replacement strategy (5-hydroxytryptophan and carbidopa administration), an approach that may have broader applicability in myelopathies of diverse etiology where descending serotonergic projections are compromised.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Horvath GA,Meisner L,Selby K,Stowe R,Carleton B

doi

10.1016/j.jns.2017.04.047

subject

Has Abstract

pub_date

2017-07-15 00:00:00

pages

59-62

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(17)30290-3

journal_volume

378

pub_type

杂志文章

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