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Methylprednisolone increases dystrophin levels by inhibiting myotube death during myogenesis of normal human muscle in vitro.

Abstract：

:The glucocorticoid methylprednisolone (Mepd) increased dystrophin and myosin heavy chain levels in differentiated cultures of cloned human myoblasts. Mepd increased the number of myotubes per area by preventing myotube death and detachment during myogenesis in vitro. Myotube death was the result of an endogenous process initiated early during myoblast fusion. It occurred between days 4 and 5 of differentiation (3 days after its initiation) and was inhibited by cycloheximide, indicating that a programmed death mechanism may be involved. Inhibition of myotube death accounted for the increased levels of muscle-specific proteins; the amount of dystrophin per myonucleus was the same with or without Mepd treatment. These effects of glucocorticoids on primary muscle cultures may bear on the recent observation that prednisone transiently enhances muscle function in Duchenne muscular dystrophy.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Sklar RM,Brown RH Jr

doi

10.1016/0022-510x(91)90019-4

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

73-81

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(91)90019-4

journal_volume

101

pub_type

杂志文章

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