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High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease.

Abstract：

:High resolution positron emission tomography (PET) with the newly developed HRRT scanner (Siemens/CTI) permits the reliable quantification of 18-Fluorodeoxyglucose (FDG) uptake as a marker of neuronal activity in small subcortical nuclei which are involved in the pathophysiology of Parkinson's disease (PD). We investigated the normalized cerebral metabolic rates of glucose (nCMRGlc) with HRRT PET in basal ganglia (BG) nuclei of 10 early-stage PD patients and in 9 healthy volunteers. PET data were co-registered to magnetic resonance images and analyzed in a three-dimensional volume-of-interest (VOI) approach. After normalization for global brain activity, PD patients showed a significantly higher nCMRGlc than controls bilaterally in the BG output nuclei (pallidum, substantia nigra) and unilateral in the caudate and putamen. The metabolic activity of the nucleus accumbens, the subthalamic nucleus, the corpus amygdaloideum and the red nucleus was normal. These first HRRT PET data in living parkinsonian humans extend previous brain imaging findings of abnormal network activity in the BG and confirm output nuclei and striatal overactivation also in early stage PD patients.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Eggers C,Hilker R,Burghaus L,Schumacher B,Heiss WD

doi

10.1016/j.jns.2008.08.029

subject

Has Abstract

pub_date

2009-01-15 00:00:00

pages

27-30

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(08)00433-4

journal_volume

276

pub_type

杂志文章

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