当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese--a case control study.

Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese--a case control study.

Abstract：

BACKGROUND:Interleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase the risk of MS. However, their effects on NMO have been less well studied. METHODS:Fifty-two anti-aquaporin 4 antibody-positive NMO patients, 69 anti-aquaporin 4 antibody-negative conventional MS patients, and 131 controls were genotyped for the IL-17A rs2275913 and IL-17F rs763780 single nucleotide polymorphisms by DNA sequencing. RESULTS:Significantly higher frequencies of the rs763780 T allele (p(uncorr)=0.011) and TT genotype (p(uncorr)=0.007, p(corr)=0.042) were observed in NMO patients versus controls. CONCLUSIONS:The rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Wang H,Zhong X,Wang K,Qiu W,Li J,Dai Y,Hu X

doi

10.1016/j.jns.2011.11.005

subject

Has Abstract

pub_date

2012-03-15 00:00:00

pages

26-8

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(11)00657-5

journal_volume

314

pub_type

杂志文章

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