当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis (ALS).

Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis (ALS).

Abstract：

:Amyotrophic lateral sclerosis (ALS) mainly affects the motor neurons but may also include other organs such as the skin. We aimed to determine whether matrix metalloproteinases could provide a link between neuronal degeneration and skin alterations in ALS. We measured CSF, serum and skin tissue MMP-2 and MMP-9 using ELISA and malondialdehyde (MDA), a marker of lipid peroxidation, using High Performance Liquid Chromatography (HPLC) in 54 ALS patients and 36 controls. We found CSF and skin MMP-9 to be elevated in ALS as compared to controls (p<0.001, p=0.03, respectively). We observed CSF MMP-9 to be highest in patients with a rapid progressive course of disease (p=0.008). In contrast, we found no significant differences of CSF, serum or skin concentrations of MMP-2 as compared to controls. CSF MMP-2 concentrations decreased with duration of disease (p=0.04, R=-0.31). MDA was elevated in serum of ALS (p<0.001), though no correlation with MMP-2 or MMP-9 was observed. Our findings indicate a general upregulation of MMP-9 in ALS. MMP-9 seems to play a role in both neurodegeneration and skin changes in ALS and could thus be a common factor linking otherwise distant aspects of disease pathology.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Fang L,Huber-Abel F,Teuchert M,Hendrich C,Dorst J,Schattauer D,Zettlmeissel H,Wlaschek M,Scharffetter-Kochanek K,Tumani H,Ludolph AC,Brettschneider J

doi

10.1016/j.jns.2009.05.025

subject

Has Abstract

pub_date

2009-10-15 00:00:00

pages

62-6

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(09)00630-3

journal_volume

285

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases.

    abstract：:We assayed IL-6 in 105 cerebrospinal fluid (CSF) samples from patients with ALS, MS, HTLV-1 associated myelopathy (HAM), and controls. There was considerable overlap in IL-6 levels in all patient groups. The mean IL-6 in 27 patients with ALS was significantly higher than in 21 patients in the other neurological diseas...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(97)00228-1

    authors： Sekizawa T,Openshaw H,Ohbo K,Sugamura K,Itoyama Y,Niland JC

    更新日期：1998-02-05 00:00:00

  • Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry.

    abstract：OBJECTIVES:Though much information exists about the diagnosis, treatment, and epidemiology of myasthenia gravis (MG), a comprehensive data registry and biorepository is critical to better understand disease mechanisms, treatment outcomes, and the impact of treatment strategies. We aimed to design and implement the "Exp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116830

    authors： Anil R,Kumar A,Alaparthi S,Sharma A,Nye JL,Roy B,O'Connor KC,Nowak RJ

    更新日期：2020-07-15 00:00:00

  • Transplanted human bone marrow cells generate new brain cells.

    abstract：:Multiple studies have reported that adult cells of bone marrow origin can differentiate into muscle, skin, liver, lung, epithelial cells, and neurons. To determine whether such cells might produce neurons and other cells in the human brain, we examined paraffin sections from female patients who had received bone marro...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2005.03.017

    authors： Crain BJ,Tran SD,Mezey E

    更新日期：2005-06-15 00:00:00

  • Prospective study of clinical epidemiology of Guillain-Barré syndrome in Harbin, China.

    abstract：:Clinical manifestations, outcomes, prognostic indicators, and clinico-epidemiological subgroups were described based on the information of 71 patients with Guillain-Barré syndrome (GBS), who were identified from a prospective survey in Harbin, China during a 1-year period from 1 October 1997 to 30 September 1998. GBS ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(03)00187-4

    authors： Cheng Q,Wang DS,Jiang GX,Han H,Zhang Y,Wang WZ,Fredrikson S

    更新日期：2003-11-15 00:00:00

  • Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry.

    abstract：:The REduction of Atherothrombosis for Continued Health (REACH) Registry is a large, international, prospective cohort of patients with atherothrombosis or multiple (>or=3) risk factors (MRFs) for atherothrombosis. Japanese patients (n=5193) were enrolled into the REACH registry between August and December 2004. One-ye...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2009.09.011

    authors： Uchiyama S,Goto S,Matsumoto M,Nagai R,Origasa H,Yamazaki T,Shigematsu H,Shimada K,Yamada N,Bhatt DL,Steg PG,Ikeda Y,REduction of Atherothrombosis for Continued Health Registry Investigators.

    更新日期：2009-12-15 00:00:00

  • Immunofluorescence study of lymphocytic infiltration in gliomas. Identification of T-lymphocytes.

    abstract：:Five human brain tumours (3 glioblastomas and 2 astrocytomas) and 5 rat brain tumours induced in Sprague--Dawley animals by systemic administration of N-methyl-N-nitrosourea (3 pleomorphic gliomas and 2 mixed gliomas) were studied. The human brain tumours were surgical specimens excised from patients with no cranial s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90200-3

    authors： Stavrou D,Anzil AP,Weidenbach W,Rodt H

    更新日期：1977-08-01 00:00:00

  • Asymmetric dynamic center-of-pressure in Parkinson's disease.

    abstract：BACKGROUND:Gait disturbance gradually worsens as Parkinson's disease (PD) progresses, which significantly affects the quality of life of PD patients. Treadmill-based gait analysis systems can measure gait parameters including the dynamic center-of-pressure (COP) trajectory during ambulation. In this study, we hypothesi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116559

    authors： Shin C,Ahn TB

    更新日期：2020-01-15 00:00:00

  • Steroids and brain atrophy in multiple sclerosis.

    abstract：:In this review, we focus on different pathogenetic mechanisms of corticosteroids that induce short- and long-term brain volume fluctuations in a variety of systemic conditions and disorders, as well as on corticosteroid-induced immunomodulatory, immunosuppressive and anti-inflammatory mechanisms that contribute to the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2005.03.006

    authors： Zivadinov R

    更新日期：2005-06-15 00:00:00

  • Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat.

    abstract：:A nitric oxide releasing compound, NOC-18, was injected intrathecally in order to determine the role of NO in spinal nociceptive mechanisms in rats. The nociceptive threshold was evaluated by the radiant heat tail-flick test. The effects of intrathecal injection of N-nitro-L-arginine methyl ester (L-NAME), an NO synth...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00188-3

    authors： Inoue T,Mashimo T,Shibuta S,Yoshiya I

    更新日期：1997-12-09 00:00:00

  • Acute vertigo due to hemispheric stroke: a case report and comprehensive review of the literature.

    abstract：:Acute cortical lesions rarely cause vertigo. We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nausea due to middle cerebral artery infarction. The central origin of the acute vestibular syndrome was revealed by a normal head imp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2014.02.005

    authors： von Brevern M,Süßmilch S,Zeise D

    更新日期：2014-04-15 00:00:00

  • Peripheral nerve involvement in pernicious anaemia.

    abstract：:Impairment of nervous function and thiamine metabolism were studied in 40 patients suffering from pernicious anaemia, 20 of whom had not been treated and the other 20 were on hydroxocobalamin therapy. Of the untreated patients 13 (65%) showed signs of peripheral nerve dysfunction with reduced conduction velocities, as...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90180-x

    authors： Cox-Klazinga M,Endtz LJ

    更新日期：1980-03-01 00:00:00

  • Lower urinary tract dysfunction in patients with functional movement disorders.

    abstract：INTRODUCTION:Functional movement disorders (FMD) are not associated with the kind of structural or biochemical alterations seen in other movement disorders and therefore would be unlikely to be associated with lower urinary tract (LUT) dysfunction. However, LUT symptoms have been observed in patients with FMD. OBJECTI...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.12.048

    authors： Batla A,Pareés I,Edwards MJ,Stamelou M,Bhatia KP,Panicker JN

    更新日期：2016-02-15 00:00:00

  • Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia.

    abstract：:Primary progressive aphasia (PPA) is a group of disorders with progressive language impairment. Abnormal behaviour may develop in PPA as the disease evolves, but the clinical features and brain basis of behavioural change in PPA have not been fully defined. 33 PPA patients (9 semantic dementia, SD, 14 progressive nonf...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.03.012

    authors： Rohrer JD,Warren JD

    更新日期：2010-06-15 00:00:00

  • DNA and RNA antibodies in serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients.

    abstract：:DNA and RNA (nucleic) antibodies were found in the CSF of 18 patients with multiple sclerosis (MS) (out of 45), 11 with subacute sclerosing panencephalitis (SSPE) (out of 12) and 9 controls (out of 30). Viral (measles and rubella, by HAI) antibodies were present in all SSPE, 23 MS and 11 control patients. A clear corr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90225-3

    authors： Schuller E,Delasnerie N,Lebon P

    更新日期：1978-06-01 00:00:00

  • Direct immunofixation after isoelectric focusing. An improved method for identification of cerebrospinal fluid and serum proteins.

    abstract：:An improved method for identification of CSF and serum proteins is described, using analytical isoelectric focusing followed by direct immunofixation in polyacrylamide gel. This method offers high sensitivity together with retained resolution after isoelectric focusing and is technically easy to perform. The gamma-tra...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90059-5

    authors： Stibler H

    更新日期：1979-07-01 00:00:00

  • Necessity of continuous antigenic stimulation by the locally retained antigens in chronic relapsing experimental allergic encephalomyelitis.

    abstract：:Chronic relapsing experimental allergic encephalomyelitis has been induced in juvenile strain 13 guinea pigs with isologous spinal cord in Freund's complete adjuvant. Retention of antigen at the injection site and in the draining lymph nodes was studied by immunocytochemical staining with antiserum to myelin basic pro...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90145-x

    authors： Tabira T,Itoyama Y,Kuroiwa Y

    更新日期：1984-10-01 00:00:00

  • Physical activity and subclinical MRI cerebral infarcts: the ARIC Study.

    abstract：BACKGROUND:We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. OBJECTIVES:We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2009.04.011

    authors： Dubbert PM,Penman AD,Evenson KR,Reeves RR,Mosley TH Jr

    更新日期：2009-09-15 00:00:00

  • Improvement in motor evoked potentials and clinical course post-steroid therapy in multiple sclerosis.

    abstract：:Motor evoked potentials (MEP) were recorded in 23 patients with definite relapsing multiple sclerosis before and after treatment with a short course of high dose of methylprednisolone. MEP were performed together with clinical examination just before treatment, and 6 and 60 days later. The following results were obser...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90049-q

    authors： Salle JY,Hugon J,Tabaraud F,Boulesteix JM,Vallat JM,Dumas M,Poser CM

    更新日期：1992-04-01 00:00:00

  • Sleep structure and nocturnal disordered breathing in familial dysautonomia.

    abstract：:In 13 patients with familial dysautonomia sleep recordings were obtained to investigate the possibility that autonomic nervous system dysfunction plays a role in disordered breathing during sleep. Sleep structure in some of our patients was abnormal, showing decreased amount of REM sleep and increased REM latencies. A...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(83)90131-4

    authors： Gadoth N,Sokol J,Lavie P

    更新日期：1983-07-01 00:00:00

  • Electrophysiological evaluation of the afferent spinal roots and nerves in patients with conus medullaris and cauda equina lesions.

    abstract：:The clinical value and practical application of the lumbosacral evoked electrospinogram (Espg) and somatosensory cerebral evoked potentials (SEP) were investigated in 52 patients with conus medullaris or cauda equina lesions. It was shown that the destruction or compression of the conus/cauda equina region by traumati...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90113-6

    authors： Ertekin C,Mutlu R,Sarica Y,Uçkardeşler L

    更新日期：1980-12-01 00:00:00

  • Overview of sleep disturbances and their management in Parkinson plus disorders.

    abstract：:Sleep disturbance is one of the commonly reported non-motor symptoms in patients with Parkinson's disease (PD) as well as in Parkinson plus disorders such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). Although there is a wealth...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2020.116891

    authors： Bhattacharya A,Lenka A,Stezin A,Kamble N,Pal PK

    更新日期：2020-08-15 00:00:00

  • Increased cathepsin B activity in multiple sclerosis brain.

    abstract：:Cathepsin B (CB) activity was measured in aqueous extracts of frozen autopsy specimens of centrum semiovale from three MS patients, five control patients with other neurological diseases, and five normal individuals. Mean activity was significantly increased in the MS tissue compared with controls. The mean activity i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(95)00039-5

    authors： Bever CT Jr,Garver DW

    更新日期：1995-07-01 00:00:00

  • A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia.

    abstract：:We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM lambda monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)05305-1

    authors： Kira J,Inuzuka T,Hozumi I,Wada H,Tanaka K,Gondo H,Sato S,Tsuji S,Kobayashi T

    更新日期：1997-05-01 00:00:00

  • A minute demyelinating lesion causing acute positional vertigo.

    abstract：:Clinico-anatomical correlations in multiple sclerosis patients presenting with central positional vertigo are lacking. We report on a patient with acute onset positional vertigo mimicking benign paroxysmal positional vertigo with a single enhancing lesion in the inner part of the superior cerebellar peduncle, disclose...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.09.013

    authors： Anagnostou E,Varaki K,Anastasopoulos D

    更新日期：2008-03-15 00:00:00

  • Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease.

    abstract：:We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had similar CSF levels of glutamat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(96)00115-3

    authors： Jiménez-Jiménez FJ,Molina JA,Vargas C,Gómez P,Navarro JA,Benito-León J,Ortí-Pareja M,Gasalla T,Cisneros E,Arenas J

    更新日期：1996-09-15 00:00:00

  • Myoclonic involuntary movement associated with chronic manganese poisoning.

    abstract：:We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-wei...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00111-9

    authors： Ono K,Komai K,Yamada M

    更新日期：2002-07-15 00:00:00

  • The contribution of magnetic resonance imaging in the differential diagnosis of optic nerve damage.

    abstract：:In this paper we review the findings of magnetic resonance imaging (MRI) in optic neuritis and visual dysfunction due to other optic neuropathies. With advances in MRI technology, it has become possible to visualise optic nerve pathology. STIR and RARE sequences, contrast-enhanced sequences, and phased array surface c...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(99)00272-5

    authors： Gass A,Moseley IF

    更新日期：2000-01-15 00:00:00

  • Guillain-Barré syndrome as leading manifestation of graft-versus-host disease in an allogeneic bone marrow transplanted patient.

    abstract：:Guillain-Barré Syndrome (GBS) is the most frequent cause of neuromuscular paralysis in industrialized countries and usually occurs after respiratory and gastrointestinal infections. However, in rare cases GBS is associated with Graft-versus-Host Disease (GvHD). In the present case we report on a female allogeneic bone...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.01.020

    authors： Thöne J,Lamprecht S,Hohaus A,Erbguth F,Bickel A

    更新日期：2010-05-15 00:00:00

  • Altered tumor growth factor beta mRNA expression is associated with thymectomy-related clinical remission in myasthenia gravis.

    abstract：:Clinical remission in myasthenia gravis after thymectomy and immune suppressive treatment may be reflected by changes of immunoregulatory cytokines. Mononuclear cells from paired blood samples from fifteen patients with myasthenia gravis before and after thymectomy and immunosuppressive therapy were examined by in sit...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00104-4

    authors： Weissert R,Melms A,Link H

    更新日期：1997-10-03 00:00:00

  • Bayesian mapping of multiple sclerosis prevalence in the province of Pavia, northern Italy.

    abstract：:The geographical analysis of a disease risk is particularly difficult when the disease is non-frequent and the area units are small. The practical use of the Bayesian modelling, instead of the classical frequentist one, is applied to study the geographical variation of multiple sclerosis (MS) across the province of Pa...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.01.013

    authors： Bergamaschi R,Montomoli C,Candeloro E,Monti MC,Cioccale R,Bernardinelli L,Fratino P,Cosi V,PREMS (Pavia REgister of Multiple Sclerosis) Group.

    更新日期：2006-05-15 00:00:00