当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia.

A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia.

Abstract：

:We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM lambda monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Kira J,Inuzuka T,Hozumi I,Wada H,Tanaka K,Gondo H,Sato S,Tsuji S,Kobayashi T

doi

10.1016/s0022-510x(96)05305-1

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

47-52

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022510X96053051

journal_volume

148

pub_type

杂志文章

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