Abstract:
:Increased resistance to ischemic nerve conduction failure (RINCF) has been demonstrated in the spontaneously diabetic BB Wistar rat as well as in non-insulin dependent but hyperglycemic litter-mates. There is marked variability in the severity of the ischemic resistance in insulin dependent rats but not in the non-insulin dependent litter-mates suggesting that the administration of insulin could acutely alter RINCF. We therefore studied the effects of rapid normalization of the blood glucose on RINCF in diabetic rats. Injection of insulin produced a rapid fall in blood glucose to normal levels by 2 h. This was closely followed by a significant fall in RINCF which reached normal levels by the time that the blood glucose had been normal for 2 h. These results suggest that increased RINCF in diabetes is a function of the availability of substrate for energy metabolism which is directly related to the blood glucose concentration and underscores the importance of measuring the blood glucose level whenever measurements of nerve function are made.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Parry GJ,Kohzu Hdoi
10.1016/0022-510x(89)90161-5subject
Has Abstractpub_date
1989-10-01 00:00:00pages
61-7issue
1eissn
0022-510Xissn
1878-5883pii
0022-510X(89)90161-5journal_volume
93pub_type
杂志文章abstract::With the publication of a patient with severe exercise intolerance, in whom the mutated mtDNA in muscle was shown to be paternally inherited, the strict maternal inheritance of mtDNA was challenged. Paternal mtDNA inheritance may have gone unrecognized in cases of mitochondrial disease with no clear maternal pattern o...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
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doi:10.1016/0022-510x(77)90128-9
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2012.05.050
更新日期:2012-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2007-06-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1988-02-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(77)90093-4
更新日期:1977-10-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/s0022-510x(99)00282-8
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1996-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(97)00150-0
更新日期:1997-11-06 00:00:00
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journal_title:Journal of the neurological sciences
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doi:10.1016/j.jns.2010.10.014
更新日期:2011-02-15 00:00:00
abstract::Autoimmune mechanisms are thought to have a major role in the pathogenesis of multiple sclerosis (MS) and vitamin D is hypothesised to contribute to disease susceptibility. Cow's milk allergy (CMA) is a common childhood allergy arising from an immune system imbalance and can also lead to vitamin D deficiency due to da...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2009.10.021
更新日期:2010-04-15 00:00:00
abstract::Areas of persistent demyelination were created in the dorsal columns of the cat spinal cord by injecting ethidium bromide into white matter which had previously been exposed to 40 Grays of X-irradiation. In the centre of such lesions demyelinated axons occurred in a glial-free area while axons next to normal tissue we...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(85)90088-7
更新日期:1985-09-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2014-11-15 00:00:00
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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更新日期:2012-04-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2002-11-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(77)90103-4
更新日期:1977-03-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.jns.2006.05.010
更新日期:2006-10-25 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(75)90116-1
更新日期:1975-09-01 00:00:00
abstract::We examined insulin-like growth factor I (IGF-I)-dependent phosphorylation and protein tyrosine kinase (PTK) activity in cerebellar cortex of normal humans, patients with olivopontocerebellar atrophy (OPCA) ("C" kindred) and in lurcher mutant mouse, a suggested animal model for OPCA. PTK activity and IGF-I-dependent p...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(99)00285-3
更新日期:2000-01-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jns.2019.04.029
更新日期:2019-06-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2009.03.008
更新日期:2009-06-15 00:00:00