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The presence of autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptor in the blood serum of patients with epilepsy.

Abstract：

:We have analyzed the serum from patients with refractory epilepsy for the presence of autoreactive antibodies to AMPA glutamate receptor subunits. The presence and the level of autoantibodies were assessed using immunoblot and ELISA with synthetic peptides specific for subregions of AMPA glutamate receptor subunits. Patients with refractory epilepsy exhibited strong immunoreactivity to GluR1 subunit compared to healthy donors and patients with Parkinson's disease and Alzheimer's disease. Weak immunoreactivity to other AMPA glutamate receptor subunits was also detected and the signal was diminished in the raw GluR4>GluR3>GluR2. The occurrence of autoantibodies to specific neurotransmitter subunits in the sera of patients with refractory epilepsy suggest that autoimmune process may underlie this disorder.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Dambinova SA,Izykenova GA,Burov SV,Grigorenko EV,Gromov SA

doi

10.1016/s0022-510x(97)00150-0

subject

Has Abstract

pub_date

1997-11-06 00:00:00

pages

93-7

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022510X97001500

journal_volume

152

pub_type

杂志文章

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