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Gangliosides containing glucosamine and galactosamine in transformed Tay-Sachs disease and normal human brain cell lines.

Abstract：

:Human SV-40 transformed brain cell lines derived from Tay-Sachs disease (TSD) and normal fetal cerebra were grown in culture and analyzed for their ganglioside content. Both the TSD and normal cells contained GM3, GM2, and a novel triheoxyl N-acetylglucosamine-containing ganglioside. In order to increase tumorigenicity, the cells were cloned on soft agar. The cloned cells still contained GM3, GM2, and the N-acetylglucosamine-containing ganglioside. The per cent distribution of gangliosides in the TSD and normal SV-40 transformed cell lines was surprisingly similar despite the fact that the TSD transformed cells still lacked hexosaminidase A, the isoenzyme which is required to break down GM2.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Schneck L,Hoffman LM,Brooks SE,Amsterdam D

doi

10.1016/s0022-510x(80)80013-x

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

123-8

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(80)80013-X

journal_volume

45

pub_type

杂志文章

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