Micro-RNAs in ALS muscle: Differences in gender, age at onset and disease duration.

Abstract:

:Few studies have explored the role of microRNAs (or miRNAs) in Amyotrophic Lateral Sclerosis (ALS) muscle, possibly because of the difficulty in obtaining samples and because this is a rare disease. We measured the expression levels of muscle-specific miRNAs (miRNA-1, miRNA-206, miRNA-133a, miRNA-133b, miRNA-27a) and inflammatory/angiogenic miRNAs (miRNA-155, miRNA-146a, miRNA-221, miRNA-149*) in the muscles of 13 ALS patients and controls. To highlight differences, patients were subdivided according to their gender, age at onset of symptoms, and disease duration. A significant over-expression of all miRNAs was observed in ALS patients versus controls, in male patients versus females, in patients with early onset versus patients with late onset, and in patients with long disease duration versus patients with short duration. A differential expression of miRNAs according to gender could be explained by the hormonal regulation which determines the body muscle mass. The course of the disease might reflect differential degree of muscle atrophy and signaling at miRNA levels. An evident role is also played by inflammatory/angiogenetic factors as shown by the observed miRNA changes.

journal_name

J Neurol Sci

authors

Pegoraro V,Merico A,Angelini C

doi

10.1016/j.jns.2017.07.008

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

58-63

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(17)30432-X

journal_volume

380

pub_type

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