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Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship.

Abstract：

:In this study, we investigated the dose-effect relationship and safety of tissue plasminogen activator (tPA) for the treatment of intraventricular hemorrhage/hematoma (IVH) in rats. Adult male Sprague-Dawley rats were injected with autologous blood into the left lateral ventricle to establish IVH. Two hours later, Ringer's saline or 0.25-2 microg of tPA were administered directly to the IVH over 3 h. The regional cerebral blood flow (rCBF) on the surface of the left parietal cortex was measured with laser Doppler flowmetry. Twenty-four hours after the build-up of IVH, the brains were removed for morphometrical and histological studies. A dose of 0.5-2 microg tPA significantly diminished the IVH in a dose-dependent manner (p < 0.001). However, only the dose of 0.5 microg tPA significantly ameliorated the reduction of rCBF 24 h after IVH (p < 0.01). TPA did not improve the ventricular dilatation on the side with IVH. Instead, 1-2 microg of tPA caused additional injuries, including intraventricular leukocytosis and edema of periventricular tissues and choroid plexus on both hemispheres. These results indicate that higher doses of tPA may have detrimental effects on the brain. The dosage rate of 0.5 microg seems beneficial to treat 5 microl of IVH (equals to a dose of 0.1 mg/ml blood) in our model in terms of the satisfactory fibrinolysis and less damage to the brain.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Wang YC,Lin CW,Shen CC,Lai SC,Kuo JS

doi

10.1016/s0022-510x(02)00243-5

subject

Has Abstract

pub_date

2002-10-15 00:00:00

pages

35-41

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022510X02002435

journal_volume

202

pub_type

杂志文章

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