Abstract：
BACKGROUND:Cerebrospinal fluid (CSF) is essential for the medical workup of patients with neurological conditions and for disease-modifying clinical trials. Post- lumbar puncture (LP) headache is influenced by both operator and patient-related factors, including needle type and gauge, age, and gender. OBJECTIVES:We aimed to assess whether CSF volume measured based on pre-procedural brain MRI is associated with the risk of developing a post-LP headache. METHODS:In total, n = 117 participants (n = 58 Parkinson's disease patients, and n = 59 healthy controls) underwent an LP and CSF collection. Of those, n = 89 underwent MRI scans prior to the LP procedure acquiring high-resolution 3D magnetization-prepared rapid gradient echo (MP-RAGE) T1-weighted images using a 3 T MR scanner. Clinical and behavioral assessments were performed for all participants, and CSF was assessed for content. The T1-weighted images were segmented producing gray matter, white matter, and CSF probability maps. RESULTS:Thirteen participants (11.1%) experienced post-LP headache. They were younger (p = .033) and had lower CSF volumes (p = .040) compared to participants that did not develop a post LP headache. CONCLUSIONS:The results of this pilot study suggest that low CSF volumes might increase the risk for the occurrence of post-LP adverse events and should be taken into consideration when planning LP's.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Droby A,Omer N,Gurevich T,Kestenbaum M,Mina Y,Cedarbaum JM,Aizenstein O,Giladi N,Mirelman A,Thaler Adoi
10.1016/j.jns.2020.117059subject
Has Abstractpub_date
2020-10-15 00:00:00pages
117059eissn
0022-510Xissn
1878-5883pii
S0022-510X(20)30396-8journal_volume
417pub_type
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