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Advances in vasospasm treatment and prevention.

Abstract：

:Outcome after aSAH depends on several factors, including the severity of the initial event, perioperative medical management, surgical variables, and the incidence of complications. Cerebral vasospasm (CV) is ure to consistently respond to treatment, emphasizing the need for further research into the underlying mechanisms of SAH-induced cerebrovascular dysfunction. To this end, our paper reviews the relevant literature on the main therapies employed for CV after aSAH and discusses possible avenues for future investigations. Current management of this condition consists of maximal medical therapy, including triple H regimen and oral administration of calcium antagonists, followed by endovascular balloon angioplasty and/or injection of vasodilatory agents for refractory cases. As the precise pathophysiology of CV is further elucidated, the development of promising investigational therapies will follow.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Komotar RJ,Zacharia BE,Valhora R,Mocco J,Connolly ES Jr

doi

10.1016/j.jns.2007.04.046

subject

Has Abstract

pub_date

2007-10-15 00:00:00

pages

134-42

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(07)00313-9

journal_volume

261

pub_type

杂志文章,评审

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