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Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects.

Abstract：

RATIONALE:Hypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the reflection of a high energy metabolic level, but this alteration seems controversial. The main objective of the study was to confirm the existence of HM during ALS compared to healthy subjects. METHODS:A cohort of ALS patients was compared to a control group without metabolic disorder. The assessment included anthropometric criteria measurements, body composition by bioelectric impedance analysis and resting energy expenditure (REE) by indirect calorimetry. HM was defined as a variation > +10% between measured and calculated REE. Statistical analysis used Mann-Withney and Chi2 tests. Multivariate analysis included logistic regression. RESULTS:287 patients and 75 controls were included. The metabolic level was higher in ALS patients (1500 kcal/24 h [1290-1693] vs. 1230 kcal/24 h [1000-1455], p < 0.0001) as well as the REE/fat free mass ratio (33.5 kcal/kg/24 h [30.4-37.8] vs. 28.3 kcal/kg/24 h [26.1-33.6], p < 0.0001). 55.0% of ALS patients had HM vs. 13.3% of controls (p < 0.0001). HM was strongly and positively associated with ALS (OR = 9.50 [4.49-20.10], p < 0.0001). CONCLUSIONS:HM in ALS is a reality, which affects more than half of the patients and is associated with ALS. This work confirms a very frequent metabolic deterioration during ALS. The identification of HM can allow a better adaptation of the patients' nutritional intake.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Fayemendy P,Marin B,Labrunie A,Boirie Y,Walrand S,Achamrah N,Coëffier M,Preux PM,Lautrette G,Desport JC,Couratier P,Jésus P

doi

10.1016/j.jns.2020.117257

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

117257

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(20)30593-1

journal_volume

420

pub_type

杂志文章

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