当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Progression in multiple sclerosis: further evidence of an age dependent process.

Progression in multiple sclerosis: further evidence of an age dependent process.

Abstract：

:The relapsing-remitting phase and the progressive phase of multiple sclerosis (MS) seem to be the result of distinct pathophysiological processes. Previous research on the natural history of MS was largely focussed on relapses and disability scores. In this study we evaluated 438 patients with secondary or primary progressive MS. The influence of gender, initial disease course, onset manifestation and age at disease onset on age at progression and time to progression were evaluated with Kaplan-Meier survival analysis and Cox multivariate regression models. The analysis of these data showed that the initial disease course (SPMS or PPMS) had no influence on the age at progression. Gender had no influence on age at progression in PPMS and SPMS patients nor on time to progression in SPMS patients. PPMS patients with visual or brainstem/cerebellar onset had a significantly younger age at progression. SPMS patients with motor onset had a significantly higher age at progression and longer time to progression. Time to progression was significantly shorter in SPMS patients with higher age at disease onset. Our data give further support to the notion that progression in MS is an age dependent process independent of relapses.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Koch M,Mostert J,Heersema D,De Keyser J

doi

10.1016/j.jns.2007.01.067

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

35-41

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(07)00092-5

journal_volume

255

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Posterior tibial and sural nerve somatosensory evoked potentials in dystrophia myotonica.

    abstract：:Somatosensory evoked potentials (SEPs) were recorded in a group of 18 patients with dystrophia myotonica and in 28 control subjects after stimulating the right and left posterior tibial (SEP-PT) and sural (SEP-S) nerves at the ankles. Recording electrodes were placed in the popliteal fossae, overlying the L3 spinal ve...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(85)90187-x

    authors： Bartel P,Lotz B,Robinson E,Van der Meyden C

    更新日期：1985-08-01 00:00:00

  • LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan.

    abstract：:Previous case-control studies in Japanese and ethnic Chinese populations reported that the LRRK2 Gly2385Arg variant is a risk factor for Parkinson's disease (PD). We aimed to validate the previous findings and investigate whether cigarette smoking influences the relationship between the Gly2385Arg variant and PD. Incl...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.07.002

    authors： Miyake Y,Tsuboi Y,Koyanagi M,Fujimoto T,Shirasawa S,Kiyohara C,Tanaka K,Fukushima W,Sasaki S,Yamada T,Oeda T,Miki T,Kawamura N,Sakae N,Fukuyama H,Hirota Y,Nagai M,Fukuoka Kinki Parkinson's Disease Study Group.

    更新日期：2010-10-15 00:00:00

  • Effects of electrical stimulation in vestibular cortex areas in humans.

    abstract：:The case of a patient with focal epilepsy is reported who underwent presurgical evaluation by stereotactic intracranial electroencephalographic (EEG) recording. A subdural semi-grid electrode, consisting of three multi-channel strip electrodes, was implanted over the temporal lobe and temporo-occipital region; one mul...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.12.003

    authors： Best C,Stefan H,Hopfengaertner R,Dieterich M

    更新日期：2010-03-15 00:00:00

  • Progressive aphemia in a patient with Pick's disease: a neuropsychological and anatomic study.

    abstract：:We describe a patient with progressive aphemia with agrammatism that was later overlaid with buccofacial apraxia and pseudobulbar palsy. Pathological findings were consistent with those of classic Pick's disease with argyrophilic inclusions and neuronal achromasia, except for restricted cortical atrophy in the frontal...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00159-2

    authors： Sakurai Y,Murayama S,Fukusako Y,Bando M,Iwata M,Inoue K

    更新日期：1998-08-14 00:00:00

  • Impact of cladribine therapy on changes in circulating dendritic cell subsets, T cells and B cells in patients with multiple sclerosis.

    abstract：BACKGROUND:Cladribine causes sustained reduction in peripheral T and B cell populations while sparing other immune cells. We determined two populations of dendritic cells (DCs): namely CD1c(+)/CD19(-) (myeloid DCs) and CD303(+)/CD123(+) (plasmacytoid DCs), CD19(+) B lymphocytes, CD3(+) T lymphocytes and CD4(+) or CD8(+...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.06.003

    authors： Mitosek-Szewczyk K,Tabarkiewicz J,Wilczynska B,Lobejko K,Berbecki J,Nastaj M,Dworzanska E,Kolodziejczyk B,Stelmasiak Z,Rolinski J

    更新日期：2013-09-15 00:00:00

  • Linear lesions may assist early diagnosis of neuromyelitis optica and longitudinally extensive transverse myelitis, two subtypes of NMOSD.

    abstract：PURPOSE:To investigate the relationship between linear lesions (LL) and the development of longitudinally extensive spinal cord lesions (LESCL) in Chinese patients with neuromyelitis optica or longitudinally extensive transverse myelitis. METHOD:The clinical records of 143 patients with these conditions were reviewed....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.11.040

    authors： Cai W,Tan S,Zhang L,Shan Y,Wang Y,Lin Y,Zhou F,Zhang B,Chen X,Zhou L,Wang Y,Huang X,Men X,Li H,Qiu W,Hu X,Lu Z

    更新日期：2016-01-15 00:00:00

  • Thalamic amnesia: Korsakoff syndrome due to left thalamic infarction.

    abstract：:In order to support the concept that a lesion of the thalamus is sufficient to cause a Korsakoff syndrome, we are presenting 5 patients, all of whom developed the syndrome after sustaining a left (dominant) thalamic infarction. Two patients had pure thalamic strokes followed by a permanent Korsakoff syndrome. One of t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90010-i

    authors： Cole M,Winkelman MD,Morris JC,Simon JE,Boyd TA

    更新日期：1992-07-01 00:00:00

  • Updates on Somatoform Disorders (SFMD) in Parkinson's Disease and Dementia with Lewy Bodies and discussion of phenomenology.

    abstract：:Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had ne...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.07.010

    authors： Onofrj M,Thomas A,Tiraboschi P,Wenning G,Gambi F,Sepede G,Di Giannantonio M,Di Carmine C,Monaco D,Maruotti V,Ciccocioppo F,D'Amico MC,Bonanni L

    更新日期：2011-11-15 00:00:00

  • Herpes simplex virus encephalitis in a mouse model: PCR evidence for CNS latency following acute infection.

    abstract：:We have used a mouse model of herpes simplex encephalitis produced by intranasal inoculation of virus to study the expression of viral immediate early, early and late genes and latency associated transcript (LAT) in trigeminal ganglia and brain at various times after inoculation. A PCR technique was used to detect the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90068-x

    authors： Drummond CW,Eglin RP,Esiri MM

    更新日期：1994-12-20 00:00:00

  • Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes.

    abstract：OBJECTIVE:To determine the sensitivity and specificity of clonal immunoglobulin heavy chain gene rearrangement (IGHR) analysis in the distinction of benign and malignant lymphoproliferative diseases. METHODS:A retrospective analysis was conducted of patients in whom a malignant lymphoproliferative process was suspecte...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.05.044

    authors： Baehring JM,Hochberg FH,Betensky RA,Longtine J,Sklar J

    更新日期：2006-09-25 00:00:00

  • A study of neuroendocrine dysfunction in patients of tuberculous meningitis.

    abstract：BACKGROUND:Endocrine dysfunction is known to occur in various infectious diseases of the brain. The neuroendocrine dysfunction is not well studied in patients of Tuberculous meningitis (TBM). In this study, we aimed at knowing pattern of endocrine dysfunction in newly diagnosed patients of tuberculous meningitis, struc...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.06.015

    authors： More A,Verma R,Garg RK,Malhotra HS,Sharma PK,Uniyal R,Pandey S,Mittal M

    更新日期：2017-08-15 00:00:00

  • Roentgenmorphological aspects of muscular pseudohypertrophy.

    abstract：:Using special soft tissue X-ray investigations the authors have found that the increase in volume of the calf musculature in progressive muscular dystrophy does not seem to be in complete accordance with the criteria of pseudohypertrophy. It has been demonstrated that this structural alteration of the musculature does...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90074-1

    authors： Pálvölgyi R,Gallai M

    更新日期：1979-09-01 00:00:00

  • Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke.

    abstract：:Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability o...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.09.012

    authors： Wheaton LA,Villagra F,Hanley DF,Macko RF,Forrester LW

    更新日期：2009-01-15 00:00:00

  • Untapped targets in multiple sclerosis.

    abstract：:Multiple sclerosis is a chronic inflammatory disease of the white and grey matter which results in irrevocable axonal and neuronal damage. Grey matter injury is widespread and reflects disability to a greater extent than do white matter lesions. Growing understanding of the immunopathology of multiple sclerosis is lea...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/S0022-510X(11)70003-X

    authors： Meinl E

    更新日期：2011-12-01 00:00:00

  • Practical issues in measuring autoantibodies to neuronal cell-surface antigens in autoimmune neurological disorders: 190 cases.

    abstract：OBJECTIVES:To address practical issues in measuring autoantibodies to neuronal cell-surface antigens (NSAs) in various autoimmune neurological disorders (ANDs). METHODS:We retrospectively reviewed the clinical information of 221 patients with clinically suspected ANDs who underwent antibody testing for NSAs between Ja...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.04.009

    authors： Kaneko J,Kanazawa N,Tominaga N,Kaneko A,Suga H,Usui R,Ishima D,Kitamura E,Akutsu T,Yoshida K,Nishiyama K,Iizuka T

    更新日期：2018-07-15 00:00:00

  • Friedreich ataxia with minimal GAA expansion presenting as adult-onset spastic ataxia.

    abstract：:Around a quarter of Friedreich ataxia (FA) patients, despite being homozygous for GAA expansion within the FRDA gene, show atypical presentations. Our aim is to describe the case of three brothers with long-term follow-up suffering from late onset FA manifested with spastic ataxia. The three patients belong to a famil...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00681-5

    authors： Berciano J,Mateo I,De Pablos C,Polo JM,Combarros O

    更新日期：2002-02-15 00:00:00

  • Nutritional optic neuropathies.

    abstract：:Nutritional deficiency may be the cause of a genuine optic neuropathy, sometimes associated with involvement of the peripheral nervous system. Nutritional optic neuropathies are usually bilateral, painless, chronic, insidious and slowly progressive. Most often, they present as a non-specific retrobulbar optic neuropat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2007.06.038

    authors： Orssaud C,Roche O,Dufier JL

    更新日期：2007-11-15 00:00:00

  • Physiological alterations of motor units in hemiplegia.

    abstract：:Isometric contractions of single motor units in the first dorsal interosseous muscle were recorded with an intramuscular microstimulation technique in patients with short- or long-term hemiplegia and compared with controls. In the hemiplegic patients motor units could be classified as in controls, utilizing twitch con...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(82)90203-9

    authors： Young JL,Mayer RF

    更新日期：1982-06-01 00:00:00

  • Evaluation of the drug-induced morphological differentiation of rat glioma cells (C-6) from the aspects of S-100 protein level and con A binding pattern.

    abstract：:The intracellular content of the nervous system specific protein S-100 began to increase with 4 days latency following the morphological differentiation of cultured rat glioma cells (C-6) with 1 mM dibutyryl cyclic AMP (dbcAMP), rising to approximately 10-fold over the control level at 15 days after the treatment. The...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90065-4

    authors： Tabuchi K,Furuta T,Norikane H,Tsuboi M,Moriya Y,Nishimoto A

    更新日期：1981-07-01 00:00:00

  • The refractory period of the visual evoked potential produced by pattern reversal in multiple sclerosis.

    abstract：:Refractoriness of the visual evoked potential to pattern-reversal stimulation has been studied using a light-emitting diode stimulator, the effect on a test P100 of a conditioning pattern reversal being determined for conditioning-test intervals of 20 ms, 50 ms and 100 ms. In 20 normal subjects, the latency of the tes...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(86)90064-x

    authors： Skuse NF,Burke D

    更新日期：1986-03-01 00:00:00

  • Brain volumetry counterparts of cognitive impairment in patients with multiple sclerosis.

    abstract：BACKGROUND:Cognitive impairment is frequent in multiple sclerosis (MS). Tissue-specific atrophy measures have been shown to correlate with cognitive performance in several studies. Voxel-based morphometry (VBM) aims to identify regional differences in the local composition of brain tissue and makes possible to correlat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.12.019

    authors： Sastre-Garriga J,Arévalo MJ,Renom M,Alonso J,González I,Galán I,Montalban X,Rovira A

    更新日期：2009-07-15 00:00:00

  • Twenty-four-hour heart rate power spectrum for evaluation of autonomic dysfunction in Guillain-Barré syndrome.

    abstract：:Long-term fluctuations of the heart rate have an important prognostic impact after myocardial infarction, in patients with chronic heart failure and even in elderly subjects. Autonomic dysfunction is a common complication in patients with Guillain-Barré syndrome, and particularly vagally-mediated bradyarrhythmias requ...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(99)00096-9

    authors： Flachenecker P,Reiners K

    更新日期：1999-06-01 00:00:00

  • Altered tumor growth factor beta mRNA expression is associated with thymectomy-related clinical remission in myasthenia gravis.

    abstract：:Clinical remission in myasthenia gravis after thymectomy and immune suppressive treatment may be reflected by changes of immunoregulatory cytokines. Mononuclear cells from paired blood samples from fifteen patients with myasthenia gravis before and after thymectomy and immunosuppressive therapy were examined by in sit...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00104-4

    authors： Weissert R,Melms A,Link H

    更新日期：1997-10-03 00:00:00

  • Immunofluorescence study of lymphocytic infiltration in gliomas. Identification of T-lymphocytes.

    abstract：:Five human brain tumours (3 glioblastomas and 2 astrocytomas) and 5 rat brain tumours induced in Sprague--Dawley animals by systemic administration of N-methyl-N-nitrosourea (3 pleomorphic gliomas and 2 mixed gliomas) were studied. The human brain tumours were surgical specimens excised from patients with no cranial s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90200-3

    authors： Stavrou D,Anzil AP,Weidenbach W,Rodt H

    更新日期：1977-08-01 00:00:00

  • Effects of carotid endarterectomy on cerebral blood flow and neuropsychological test performance in patients with high-grade carotid stenosis.

    abstract：:We examined the changes in cognitive function following carotid endarterectomy (CEA) in relation to the cerebral blood flow (CBF) in patients with high-grade carotid stenosis. The subjects consisted of 23 patients who underwent CEA and 17 controls matched by age and education. Single photon emission computed tomograph...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(03)00128-x

    authors： Kishikawa K,Kamouchi M,Okada Y,Inoue T,Ibayashi S,Iida M

    更新日期：2003-09-15 00:00:00

  • Reactive astrocytes in viral infections of the human brain express endothelin-like immunoreactivity.

    abstract：:In order to investigate the expression of endothelin-like immunoreactivity in astrocytes of viral infections of the human brain the avidin-biotin peroxidase complex method and a polyclonal antiserum were used. Autopsy material was obtained from 5 cases of herpes simplex encephalitis, two of progressive multifocal leuk...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)90271-2

    authors： Ma KC,Nie XJ,Höög A,Olsson Y,Zhang WW

    更新日期：1994-11-01 00:00:00

  • Interleukin-1 and interleukin-2 production by peripheral blood mononuclear cells in multiple sclerosis patients.

    abstract：:The production of interleukin-1 (IL-1) and interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBM) was assessed in multiple sclerosis (MS) patients in relapse, chronic progressive MS patients, patients with other neurological diseases (OND) and healthy subjects. Production was defined as the level of IL-1 and...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90036-6

    authors： Selmaj K,Nowak Z,Tchórzewski H

    更新日期：1988-05-01 00:00:00

  • Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses.

    abstract：:Laryngeal stridor is recognized as a characteristic clinical manifestation in patients with multiple system atrophy (MSA). However, the pathogenic mechanisms underlying this symptom are controversial. Neurogenic atrophy of the posterior cricoarytenoid muscle has been identified in cases of MSA, suggesting that larynge...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2016.01.007

    authors： Ozawa T,Sekiya K,Aizawa N,Terajima K,Nishizawa M

    更新日期：2016-02-15 00:00:00

  • White matter lesions and depression in patients with Parkinson's disease.

    abstract：:Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investig...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.07.021

    authors： Petrovic IN,Stefanova E,Kozic D,Semnic R,Markovic V,Daragasevic NT,Kostic VS

    更新日期：2012-11-15 00:00:00

  • Alcohol use and hospital readmissions following stroke: A safety net hospital experience.

    abstract：OBJECTIVE:The purpose of this study is to identify predictors of stroke-related readmissions at 30days on a safety net hospital level and suggest interventions to reduce the number of readmissions. BACKGROUND:Hospital readmissions are an important measure of the quality of health care services. Readmissions indicate u...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.12.016

    authors： Parikh S,George P,Wilson K,Rybin D,Hohler AD

    更新日期：2018-02-15 00:00:00