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Susceptibility of human skeletal muscle culture to influenza virus infection. I. Cytopathology and immunofluorescence.

Abstract：

:We found that fused human muscle in culture supports neurotropic influenza A viral infection, as demonstrated by viral growth experiments, hemadsorption, observation of cytopathic changes and detection of intracellular viral antigen. The time of peak virion production and the appearance of cytopathic effects in these experiments were similar to previously described characteristics in influenza A-susceptible organotypic cultures of other tissues. Cytopathological changes occurred earlier in mononucleated cells than in myotubes and included cell-rounding; cytoplasmic retraction, granularity and vacuolization; ribonucleic acid-containing cytoplasmic inclusions; nucleolar enlargement; and clumping of chromatin. Immunofluorescent staining demonstrated early nuclear fluorescence, followed by spread of viral antigen into the cytoplasm. A subpopulation of mononucleated cells, shown by cloning studies to be myoblasts, showed no cytopathic effects or evidence of intracellular viral antigen and was presumably resistant to neurotropic influenza A infection. The adverse effects of influenza A on fused human muscle cells in tissue culture contrast with the inability of the virus to replicate in skeletal muscle after animal inoculation in acute experiments. Therefore, host factors may affect attempts to produce an animal model of human muscle disease with this virus.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Armstrong CL,Miranda AF,Hsu KC,Gamboa ET

doi

10.1016/0022-510x(78)90101-6

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

43-57

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(78)90101-6

journal_volume

35

pub_type

杂志文章

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