Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect.

Abstract:

:A variety of neurological conditions and disease states are accompanied by pseudobulbar affect (PBA), an emotional disorder characterized by uncontrollable outbursts of laughing and crying. The causes of PBA are unclear but may involve lesions in neural circuits regulating the motor output of emotional expression. Several agents used in treating other psychiatric disorders have been applied in the treatment of PBA with some success but data are limited and these agents are associated with unpleasant side effects due to nonspecific activity in diffuse neural networks. Dextromethorphan (DM), a widely used cough suppressant, acts at receptors in the brainstem and cerebellum, brain regions implicated in the regulation of emotional output. The combination of DM and quinidine (Q), an enzyme inhibitor that blocks DM metabolism, has recently been tested in phase III clinical trials in patients with multiple sclerosis and amyotrophic lateral sclerosis and was both safe and effective in palliating PBA symptoms. In addition, clinical studies pertaining to the safety and efficacy of DM/Q in a variety of neurological disease states are ongoing.

journal_name

J Neurol Sci

authors

Miller A,Panitch H

doi

10.1016/j.jns.2006.06.030

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

67-73

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(07)00155-4

journal_volume

259

pub_type

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