Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect.


:A variety of neurological conditions and disease states are accompanied by pseudobulbar affect (PBA), an emotional disorder characterized by uncontrollable outbursts of laughing and crying. The causes of PBA are unclear but may involve lesions in neural circuits regulating the motor output of emotional expression. Several agents used in treating other psychiatric disorders have been applied in the treatment of PBA with some success but data are limited and these agents are associated with unpleasant side effects due to nonspecific activity in diffuse neural networks. Dextromethorphan (DM), a widely used cough suppressant, acts at receptors in the brainstem and cerebellum, brain regions implicated in the regulation of emotional output. The combination of DM and quinidine (Q), an enzyme inhibitor that blocks DM metabolism, has recently been tested in phase III clinical trials in patients with multiple sclerosis and amyotrophic lateral sclerosis and was both safe and effective in palliating PBA symptoms. In addition, clinical studies pertaining to the safety and efficacy of DM/Q in a variety of neurological disease states are ongoing.


J Neurol Sci


Miller A,Panitch H




Has Abstract


2007-08-15 00:00:00














  • SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.

    abstract::Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOEε4-negative Caucasian population. To investigate the potential association between the rs...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Xia M,Yu JT,Miao D,Lu RC,Zheng XP,Tan L

    更新日期:2014-01-15 00:00:00

  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status.

    abstract::We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolu...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Rohowsky-Kochan C,Molinaro D,Devereux C,Troiano R,Bansil S,Zito G,Wolansky L,Jotkowitz A,Denny T,Oleske J,Dowling P,Cook SD

    更新日期:1997-11-25 00:00:00

  • Lewy body-free nigral degeneration--a case report.

    abstract::A 70-year-old Japanese woman developed progressive, dopa-responsive parkinsonism consisting of akinesia, resting tremor, rigidity, and postural instability. Neuropathological examination revealed a marked loss of nigral neurons, but no Lewy bodies (LBs) were observed. Lewy bodies were also absent from their usual site...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Ishihara K,Nonaka A,Fukui T,Kawamura M,Shiota J,Nakano I

    更新日期:2002-06-15 00:00:00

  • Brain metal accumulation in Wilson's disease.

    abstract:INTRODUCTION:Brain metal accumulation is suggested in the pathogenesis of numerous neurodegenerative disorders. In Wilson's disease (WD), only copper has been examined. The aim of the present study was to evaluate the copper, iron, manganese, and zinc concentrations in autopsy tissue samples from the brains of WD patie...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Litwin T,Gromadzka G,Szpak GM,Jabłonka-Salach K,Bulska E,Członkowska A

    更新日期:2013-06-15 00:00:00

  • Neuropathology of S. Paulo south coast epidemic encephalitis (Rocio flavivurus).

    abstract::The neuropathology of 8 cases of S. Paulo south coast epidemic encephalitis (Rocio flavivirus), a new arbo B virus encephalitis, is described. The topographic pattern of the lesions appears to be almost specific. The gray matter is predominantly affected. Interstitial mononuclear infiltration, microglial proliferation...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Rosemberg S

    更新日期:1980-02-01 00:00:00

  • A minute demyelinating lesion causing acute positional vertigo.

    abstract::Clinico-anatomical correlations in multiple sclerosis patients presenting with central positional vertigo are lacking. We report on a patient with acute onset positional vertigo mimicking benign paroxysmal positional vertigo with a single enhancing lesion in the inner part of the superior cerebellar peduncle, disclose...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Anagnostou E,Varaki K,Anastasopoulos D

    更新日期:2008-03-15 00:00:00

  • Roentgenmorphological aspects of muscular pseudohypertrophy.

    abstract::Using special soft tissue X-ray investigations the authors have found that the increase in volume of the calf musculature in progressive muscular dystrophy does not seem to be in complete accordance with the criteria of pseudohypertrophy. It has been demonstrated that this structural alteration of the musculature does...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Pálvölgyi R,Gallai M

    更新日期:1979-09-01 00:00:00

  • Risk factors for stroke among patients with hypertension: a case-control study.

    abstract:BACKGROUND:In some African countries, more than half of the adult population are estimated to be hypertensive leading to an escalated burden of stroke in the continent. We conducted the first study to unravel the major risk factors for stroke among hypertensive patients (Nigerian-Africans) using a case-control design w...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Owolabi MO,Agunloye AM

    更新日期:2013-02-15 00:00:00

  • Early intervention with immunomodulatory agents in the treatment of multiple sclerosis.

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    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Jeffery DR

    更新日期:2002-05-15 00:00:00

  • Suppression of experimental allergic encephalomyelitis by retinoic acid.

    abstract::Administration of retinoic acid (RA) prevented the development of experimental allergic encephalomyelitis (EAE) in Lewis rats. RA suspended in corn oil was given for 3 days before the expected onset of the disease to rats immunized with myelin and to controls. The drug suppressed the neurological symptoms as well as t...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Massacesi L,Abbamondi AL,Giorgi C,Sarlo F,Lolli F,Amaducci L

    更新日期:1987-08-01 00:00:00

  • Hyperreactivity to myelin basic protein in multiple sclerosis.

    abstract::Multiple sclerosis patients, control patients with other neurological diseases, and normal volunteers were assayed in a short-term 51chromium release assay for cell-mediated cytotoxicity against lymphocyte targets coated with myelin basic protein. Multiple sclerosis patients, compared to the other two groups, were hyp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Eggers AE,Tarmin L,Plank CR,Gamboa ET

    更新日期:1981-11-01 00:00:00

  • Concordance of Mini-Mental State Examination, Montreal Cognitive Assessment and Parkinson Neuropsychometric Dementia Assessment in the classification of cognitive performance in Parkinson's disease.

    abstract:BACKGROUND:Cognitive impairment (CI) is frequently observed in Parkinson's disease (PD) and negatively influences the patient's and carer's quality of life. As a first step, assessment of CI is often accomplished by using screening instruments (level I diagnosis). Three commonly used instruments are the Mini-Mental Sta...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Scheffels JF,Fröhlich L,Kalbe E,Kessler J

    更新日期:2020-05-15 00:00:00

  • Incidence of idiopathic normal pressure hydrocephalus (iNPH): a 10-year follow-up study of a rural community in Japan.

    abstract:BACKGROUND:The epidemiology and pathophysiology of iNPH remain unclear. We aimed to investigate the incidence of iNPH in elderly inhabitants of the community, and to identify how ventriculomegaly develops on brain MRIs and how symptoms develop in iNPH patients. METHODS:In 2000, 350 inhabitants, all 70-year-olds living...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Iseki C,Takahashi Y,Wada M,Kawanami T,Adachi M,Kato T

    更新日期:2014-04-15 00:00:00

  • Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomeylitis. Preliminary report.

    abstract::Three patients with acute disseminated encephalomyelitis (ADE) and 4 patients in the terminal stages of multiple sclerosis (MS) were subjected to treatment with Cop 1, a synthetic copolymer of amino acids, which had previously been shown to have a beneficial effect in the treatment of experimental allergic encephalomy...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Abramsky O,Teitelbaum D,Arnon R

    更新日期:1977-04-01 00:00:00

  • Cingulate infarction: A neuropsychological and neuroimaging study.

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    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kumral E,Erdoğan CE,Bayam FE,Arslan H

    更新日期:2019-07-15 00:00:00

  • Late onset cerebello-pontomesencephalic degeneration.

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    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: al-Din AS,al-Zuhair AG,al-Salem MK,al-Nassar KE,Rudwan MA,Khafaja S,Hamawi T

    更新日期:1989-11-01 00:00:00

  • Experimental ischemic myopathy. Effects of aortic ligation and serotonin.

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    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kelts KA,Kaiser KK

    更新日期:1979-01-01 00:00:00

  • Quantitative examination of internodal length of remyelinated nerve fibres in the central nervous system.

    abstract::The internodal length of remyelinated internodes was examined by observations on teased CNS nerve fibres following primary demyelination induced by intraspinal injections of lysolecithin into the white matter of cats. A remyelinated internode was identified as a thinly-myelinated internode, where a node of Ranvier was...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Blakemore WF,Murray JA

    更新日期:1981-02-01 00:00:00

  • A Japanese family with adrenoleukodystrophy with a codon 291 deletion: a clinical, biochemical, pathological, and genetic report.

    abstract::We report a Japanese family with adrenoleukodystrophy (ALD) with a three base pair deletion (delGAG 291) in the ALD gene. A variety of phenotypes were observed within this family. While the proband (patient 1) was classified as having a rare intermediate type of adult cerebral and cerebello-brain stem forms, his young...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kano S,Watanabe M,Kanai M,Koike R,Onodera O,Tsuji S,Okamoto K,Shoji M

    更新日期:1998-06-30 00:00:00

  • Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease.

    abstract:OBJECTIVE:We estimated the extent and pattern of cardiovascular autonomic dysfunction in dementia with Lewy bodies (DLB) as compared with that in Parkinson's disease (PD). METHODS:We performed meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy of the heart and hemodynamic autonomic function testing using the Valsalva...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,收录出版


    authors: Oka H,Morita M,Onouchi K,Yoshioka M,Mochio S,Inoue K

    更新日期:2007-03-15 00:00:00

  • Yes/yes head tremor without appendicular tremor after bilateral cerebellar infarction.

    abstract::We report a 67-year-old man who developed yes/yes head tremor without appendicular tremor six weeks after right occipital and bilateral cerebellar infarction. The tremor was resting-postural. Its activity increased with excitement, decreased either after ethanol, lateroflexion or rest and stopped at sleep. Four-vessel...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Finsterer J,Muellbacher W,Mamoli B

    更新日期:1996-08-01 00:00:00

  • Median and tibial somatosensory evoked potentials. Changes in short- and long-latency components in patients with lesions of the thalamus and thalamo-cortical radiations.

    abstract::Alterations in short- and long-latency components of median and tibial somatosensory evoked potentials (SEPs) were studied in patients with lesions in the thalamus and thalamo-cortical radiations. When the lesions were located primarily in the ventro-posterior thalamus, the SEP changes consisted of the following combi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Chu NS

    更新日期:1986-12-01 00:00:00

  • Rapid sideline performance meets outpatient clinic: Results from a multidisciplinary concussion center registry.

    abstract:OBJECTIVE:This study investigated the utility of sideline concussion tests, including components of the Sports Concussion Assessment Tool, 3rd Edition (SCAT3) and the King-Devick (K-D), a vision-based test of rapid number naming, in an outpatient, multidisciplinary concussion center treating patients with both sports-r...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kyle Harrold G,Hasanaj L,Moehringer N,Zhang I,Nolan R,Serrano L,Raynowska J,Rucker JC,Flanagan SR,Cardone D,Galetta SL,Balcer LJ

    更新日期:2017-08-15 00:00:00

  • Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation.

    abstract::Cortical excitability to magnetic stimulation was investigated interictally in 10 patients with migraine with aura, 10 with migraine without aura and in 10 healthy volunteers. Thresholds, latencies and amplitudes of the magnetic-evoked potentials (MEPs) were measured from threshold to 100% stimulus intensity in 10% st...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: van der Kamp W,Maassen VanDenBrink A,Ferrari MD,van Dijk JG

    更新日期:1996-07-01 00:00:00

  • LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor.

    abstract::Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3 gene is mapped to chromosome 12q13.2, a region that is frequently deleted in a subset of glioblastoma multiforme (GBM). It has been reported that perinuclear LRIG3 staining correlated with low WHO grade of glioma and better survival of the patients. However...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Guo D,Yang H,Guo Y,Xiao Q,Mao F,Tan Y,Wan X,Wang B,Lei T

    更新日期:2015-03-15 00:00:00

  • Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study.

    abstract:BACKGROUND:The impact of deep brain stimulation (DBS) on cognitive and urinary disorders, falls, and eventually hospitalizations and mortality in Parkinson's disease (PD) is still debated. OBJECTIVE:We compared the rates of dementia, mild cognitive impairment (MCI), urinary incontinence, nocturia, falls, hospitalizati...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究


    authors: Scelzo E,Beghi E,Rosa M,Angrisano S,Antonini A,Bagella C,Bianchi E,Caputo E,Lena F,Lopiano L,Marcante A,Marceglia S,Massaro F,Modugno N,Pacchetti C,Pilleri M,Pozzi NG,Romito LM,Santilli M,Tamma F,Weis L,Zibetti

    更新日期:2019-10-15 00:00:00

  • Ingested (oral) anti-IL-12/23 inhibits EAE.

    abstract:BACKGROUND:Blocking the activity of IL-12/23 can inhibit autoimmune diseases such as psoriasis. OBJECTIVE:We examined whether an antibody against IL-12/23, ustekinumab (UTZ) (Stelera®), used clinically in psoriasis would have similar anti-inflammatory effects in EAE after oral administration. DESIGN/METHODS:B6 mice w...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Brod SA

    更新日期:2016-02-15 00:00:00

  • Abnormal apocrine secretory cell mitochondria in a Huntington disease patient.

    abstract::Over two decades, a 42-year old woman experienced the gradual onset of choreic involuntary movements, dystonia, and tics. Decreased caudate nucleus metabolism on 2-deoxyglucose PET scan and a heterozygous 49-CAG repeat expansion within the HTT gene established the diagnosis of HD, although no other family history was ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Sidiropoulos C,LeWitt P,Hashimoto K

    更新日期:2012-12-15 00:00:00

  • Evaluation of a screening tool for the identification of neurological disorders in rural Uganda.

    abstract:BACKGROUND:Neurological disorders are common in sub-Saharan African, but accurate neuroepidemiologic data are lacking from the region. We assessed a neuroepidemiological screening tool in a rural Ugandan cohort with high HIV prevalence. METHODS:Participants were recruited from the Rakai Neurology Study in rural Rakai ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Tran A,Thakur KT,Nakasujja N,Nakigozi G,Kisakye A,Batte J,Mayanja R,Anok A,Gray RH,Wawer MJ,Rubin LH,Sacktor N,Saylor D

    更新日期:2020-12-24 00:00:00

  • Sympathetic skin response: a decade later.

    abstract::Sympathetic skin response (SSR) is a simple, reproducible test of function of a polysynaptic reflex having diverse afferents, a common efferent pathway through the spinal cord, pre and post-ganglionic sympathetic fibers and with sweat glands as effectors. The reflex is co-ordinated in the posterior hypothalamus or upp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Arunodaya GR,Taly AB

    更新日期:1995-04-01 00:00:00