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Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome.

Abstract：

OBJECTIVES:Several studies have established the relevance of S-100 in blood as a marker of brain damage after traumatic brain injury. However, a more specific marker is required and glial fibrillary acidic protein (GFAP) is considered to be a good candidate. METHODS:In order to assess the increase of GFAP in serum (s-GFAP) after a severe traumatic brain injury (TBI) we collected daily serum samples from 59 patients with severe TBI starting on the day of the trauma. S-GFAP was measured using a sandwich ELISA. The Glasgow outcome scale (GOS) assessed outcome after 1 year. RESULTS:All but one patient had maximal s-GFAP values above the laboratory reference value (median increased 10-fold). The highest detected levels were seen during the first days after TBI and then decreased gradually. Patients with unfavourable outcome had significantly (p<0.001) higher maximal s-GFAP values in the acute phase compared with patients with favourable outcome. All patients (n=5) with s-GFAP>15.04 microg /L died (reference level<0.15 microg/L). We found no significant difference in the maximal s-GFAP levels of patients with isolated brain injury in comparison with patients with multiple traumas. CONCLUSION:Serum-GFAP is increased during the first days after a severe traumatic brain injury and related to clinical outcome.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Nylén K,Ost M,Csajbok LZ,Nilsson I,Blennow K,Nellgård B,Rosengren L

doi

10.1016/j.jns.2005.09.007

subject

Has Abstract

pub_date

2006-01-15 00:00:00

pages

85-91

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(05)00342-4

journal_volume

240

pub_type

杂志文章

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