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Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability.

Abstract：

OBJECTIVE:This study used reaction time (RT) as an objective marker of cognitive fatigue and fatigability in patients with multiple sclerosis (MS). METHOD:RT was measured in fifteen healthy controls and in thirty MS patients with cognitive fatigue identified with the Fatigue Scale for Motor and Cognitive Function (FSMC). Secondary fatigue was excluded through the Epworth Sleepiness Scale and the Beck Depression Inventory. RT was measured at rest (t1), following a 2.5 hour test session inducing high cognitive load (t2), and a one hour recovery period (t3). RESULTS:At rest mean RT was longer in patients than in controls (391 ms vs 205 ms). After exerting cognitive load (t2), RT in patients increased dramatically but remained unchanged in controls. After the recovery period (t3), RT returned to baseline levels in most patients. Patients further showed a significant correlation between RT and FMSC scores at t1, t2 and t3. CONCLUSION:RT performance is a suitable surrogate marker for assessing fatigue. RT is sensitive to cognitive load and the recovery from cognitive demand. It hence represents an objective index for fatigability which can inform the management and treatment of MS.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Neumann M,Sterr A,Claros-Salinas D,Gütler R,Ulrich R,Dettmers C

doi

10.1016/j.jns.2014.03.024

subject

Has Abstract

pub_date

2014-05-15 00:00:00

pages

178-82

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(14)00168-3

journal_volume

340

pub_type

杂志文章

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