Abstract:
:Motor neurone disease (MND) is a useful paradigm for many progressive disabling neurological disorders and serves as a particularly opposite model for the study of patients' responses to progressive and irreversible disability. We studied the progression of disability and the patients' perception of their health in a group of MND patients (n = 14) for 6 months from diagnosis or soon after. A comparison group of similar age, gender ratio and initial disability on Barthel index were Parkinson's disease (PD) patients, admitted because of poor response to outpatient drug therapy and increasing disability (n = 22). MND patients showed rapid deterioration in all aspects of self care and mobility, as assessed by Barthel Index. 32% PD patients showed a significant improvement in disability during their admission. For both groups, perception of their physical health on the SF36 was very poor at recruitment compared to age- and sex-matched population norms. However for patients in both groups the SF36 could not be used to monitor changes in perception of health because of floor effects. In those in whom change could be assessed, there was a trend for MND patients to deteriorate and PD patients to improve. We conclude that loss of independence in self care and failing mobility may occur more rapidly than current medical and social services can accommodate. There is a need for planning and proactive intervention to support patients and careers. The patients' perception of their physical health is poor from time of diagnosis as assessed by the SF36, but this scale cannot be used to monitor patients with MND or late stage PD over time.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Young CA,Tedman BM,Williams IRdoi
10.1016/0022-510x(95)00062-7subject
Has Abstractpub_date
1995-05-01 00:00:00pages
50-3eissn
0022-510Xissn
1878-5883pii
0022510X95000627journal_volume
129 Supplpub_type
临床试验,杂志文章abstract::Nitric oxide (NO) may be involved in myelin and oligodendrocyte injury associated with multiple sclerosis (MS), a demyelinating disease of unknown etiology. The cerebrospinal fluid (CSF) from MS patients may provide an important signal inducing a pathologic process within the central nervous system (CNS). To investiga...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(96)00164-5
更新日期:1996-10-01 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2010-11-15 00:00:00
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更新日期:1991-10-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2017-02-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:1987-10-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(98)00098-7
更新日期:1998-06-11 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(79)90039-x
更新日期:1979-04-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2013.09.036
更新日期:2014-01-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2006-12-21 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,meta分析
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更新日期:2014-01-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1978-03-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2012-12-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2015-04-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2007.09.016
更新日期:2008-03-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2007.11.019
更新日期:2008-05-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2011-03-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2014-06-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2020-07-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:1982-12-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1997-03-10 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章
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更新日期:1999-10-31 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1998-07-15 00:00:00
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更新日期:2018-11-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1977-11-01 00:00:00
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更新日期:2020-04-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2016-09-15 00:00:00
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更新日期:2020-08-15 00:00:00