Abstract:
:Despite apparent relationships between ischemic stroke and the acute phase response (APR), considerable variation in the APR exists between individuals. We therefore performed post-hoc analysis of individual APR profiles in 31 patients with ischemic stroke in relation to volume of brain infarction. Patients with ischemic stroke had serial blood samples taken within 12 h, and up to 12 months of symptom onset, for analysis of plasma C-reactive protein (CRP) and interleukin-6 (IL-6). Computed tomography (CT) brain infarct volume was measured at 5 to 7 days (median 23.9 cm(3)). An increase in plasma CRP after the admission sample was evident in 94% of patients by day 5 to 7 (median increase 558% of admission value). CRP response, assessed as area under the curve between admission and day 5 to 7, correlated strongly (r=0.62, p<0.001) with CT infarct volume. Those with greater infarct volumes had more evidence of infection, either prior to or during the first week after stroke. The pattern of response was similar for IL-6, although only 77% showed an increase in plasma IL-6 after the admission sample (median increase 148% of admission value). These data suggest that, although infection and other factors may contribute to systemic inflammation, the extent of acute brain injury after ischemic stroke is a major factor influencing the magnitude and variability of the APR.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Smith CJ,Emsley HC,Vail A,Georgiou RF,Rothwell NJ,Tyrrell PJ,Hopkins SJdoi
10.1016/j.jns.2006.09.011subject
Has Abstractpub_date
2006-12-21 00:00:00pages
77-81issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(06)00381-9journal_volume
251pub_type
杂志文章abstract::The effect of aluminum (Al) was studied in an in vitro system of cultured hippocampal neurons from fetal rats in a chemically defined medium. Neuronal aggregates interconnected by neurites were detected light and electron microscopically in control and Al-treated cultures. In the Al-treated cultures disruptions of the...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(89)90186-x
更新日期:1989-11-01 00:00:00
abstract::An immunocytochemical study of surface and cytoplasmic markers of the monocyte/macrophage lineage was undertaken on peripheral blood (PB) and cerebrospinal fluid (CSF) cells in patients with multiple sclerosis (MS) or other neurological diseases (OND) and in three healthy controls. Size and granularity were assessed b...
journal_title:Journal of the neurological sciences
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2016.12.033
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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更新日期:1991-04-01 00:00:00
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更新日期:1995-06-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(89)90063-4
更新日期:1989-07-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2012.11.020
更新日期:2013-02-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2001-08-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1976-05-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(77)90017-x
更新日期:1977-07-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(80)90032-5
更新日期:1980-07-01 00:00:00
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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更新日期:2015-02-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2007-06-15 00:00:00