The pattern of E2F1 and c-myb immunoreactivities in the CA1 region is different from those in the CA2/3 region of the gerbil hippocampus induced by transient ischemia.

abstract：:Transgenic mice that express the G93A mutation of human Cu,Zn superoxide dismutase (SOD1(G93A)), found in familial amyotrophic lateral sclerosis (FALS), showed clinical symptoms and histopathological changes of sporadic ALS, including fragmentation of the neuronal Golgi apparatus (GA). The finding of fragmented neuron...

journal_title：Journal of the neurological sciences

authors： Stieber A,Gonatas JO,Gonatas NK

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808 polymorphisms and the risk of developing essential tremor (ET) in Icelandic people. Because the results of further association studies were controversial, we conducted a...

journal_title：Journal of the neurological sciences

authors： Jiménez-Jiménez FJ,García-Martín E,Lorenzo-Betancor O,Pastor P,Alonso-Navarro H,Agúndez JA

更新日期：2012-06-15 00:00:00

abstract：:Concentrations of somatostatin-like immunoreactivity (SLI) were examined in human cerebrospinal fluid (CSF). To validate the assay it was shown that CSF which had been run over a somatostatin immunoaffinity column showed no interference with binding of synthetic standards. Reversed phase HPLC showed that the immunorea...

journal_title：Journal of the neurological sciences

authors： Beal MF,Mazurek MF,Black PM,Martin JB

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:A recent pilot study suggested spasticity improvement during glatiramer acetate (GA) treatment in multiple sclerosis (MS) patients who previously received interferon-β (IFN-β). OBJECTIVE:To evaluate changes in spasticity in MS patients switching from IFN-β to GA. METHODS:Observational, multicentre study in...

journal_title：Journal of the neurological sciences

authors： Meca-Lallana JE,Balseiro JJ,Lacruz F,Guijarro C,Sanchez O,Cano A,Costa-Frossard L,Hernández-Clares R,Sanchez-de la Rosa R,Escala Study Group.

更新日期：2012-04-15 00:00:00

abstract：:Etiology and source of amyloid deposition in senile plaques of Alzheimer's disease (AD) are still unknown. In order to know whether or not fibronectin (Fn), an adhesive glycoprotein, is related to the amyloid deposition in the senile plaque, we conducted immunohistochemical studies using polyclonal anti-Fn and affinit...

journal_title：Journal of the neurological sciences

authors： Koike F,Kunishita T,Nakayama H,Tabira T

更新日期：1988-05-01 00:00:00

abstract：INTRODUCTION:TCS is a well-established technique for diagnosis of Parkinson's disease (PD). Volumetric 3D-TCS is a promising complementary approach for objective acquisition and analysis, in particular for less experienced sonographers. This study provides baselines for Parkinson detection (sensitivity and specificity)...

journal_title：Journal of the neurological sciences

authors： Plate A,Maiostre J,Levin J,Bötzel K,Ahmadi SA

更新日期：2019-02-15 00:00:00

abstract：:This is the first report of a patient presenting with a combination of Wallenberg and posterior spinal artery syndromes. The patient developed right hemiplegia and sensory disturbances on the right side of the face and over the whole body. MRI showed infarcts of the cerebellum, medulla oblongata, and upper cervical co...

journal_title：Journal of the neurological sciences

authors： Manabe Y,Murase T,Iwatsuki K,Warita H,Hayashi T,Sakai K,Abe K

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, also called distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion body myopathy (HIBM), is a rare, progressive autosomal recessive disorder caused by mutations in the GNE gene. Here, we examined the relationship b...

journal_title：Journal of the neurological sciences

authors： Mori-Yoshimura M,Monma K,Suzuki N,Aoki M,Kumamoto T,Tanaka K,Tomimitsu H,Nakano S,Sonoo M,Shimizu J,Sugie K,Nakamura H,Oya Y,Hayashi YK,Malicdan MC,Noguchi S,Murata M,Nishino I

更新日期：2012-07-15 00:00:00

abstract：:Our objective was to apply the technique of measuring diameters of optic nerve sheath (ONSD) for the intracranial pressure assessment for the cases with traumatic head injury without hemorrhage. In a retrospective study, CT data of 720 adult patients were collected and analyzed. ONSDs were measured at the point where ...

journal_title：Journal of the neurological sciences

authors： Bekerman I,Sigal T,Kimiagar I,Vaiman M

更新日期：2016-09-15 00:00:00

abstract：:Although lomerizine is used as a first-line prophylactic drug for migraines in Japan, approximately 30% of patients fail to respond to this treatment. On the basis of medical records, we investigated the involvement of clinical factors in response to lomerizine used in patients with migraine as primary headache and es...

journal_title：Journal of the neurological sciences

authors： Ishii M,Katoh H,Kurihara T,Kawamura M,Shimizu S

更新日期：2013-12-15 00:00:00

abstract：:A blink reflex consists of an early unilateral component, R1, and a late bilateral component, R2. During an acute phase of hemispheric cerebrovascular accident, R1 and R2 were abnormal in 30 and 50 of 66 patients, respectively. Paired stimuli usually corrected R1 but not R2, which was profoundly suppressed. The discre...

journal_title：Journal of the neurological sciences

authors： Kimura J,Wilkinson JT,Damasio H,Adams HR Jr,Shivapour E,Yamada T

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Age of onset modifiers are of considerable importance in Alzheimer's and related dementias. Arboleda-Valesquez et al., reporting on a single PSEN1 subject, suggested that homozygosity for the Christchurch variant of APOE could represent such a modifier. METHODS:We studied APOE Christchurch and Kloth-VS ge...

journal_title：Journal of the neurological sciences

authors： Yu CE,Chen S,Jayadev S,Bird T

更新日期：2020-11-15 00:00:00

abstract：:Proinflammatory cytokines contribute to the regulation of the disease process in inflammatory neuropathies. Cellular localisation of cytokine expression in CIDP nerve biopsies should provide further insight into the pathogenic mechanisms of the disease and the individual cells involved. In this study in situ hybridisa...

journal_title：Journal of the neurological sciences

authors： Mathey EK,Pollard JD,Armati PJ

更新日期：1999-02-01 00:00:00

abstract：:There is evidence that visuo-spatial capacity can become overloaded when processing a secondary visual task (Dual Task, DT), as occurs in daily life. Hence, we investigated the influence of the visuo-spatial interference in the identification of emotional facial expressions (EFEs) in early stages of Parkinson's diseas...

journal_title：Journal of the neurological sciences

authors： García-Rodríguez B,Guillén CC,Barba RJ,io Valladolid GR,Arjona JA,Ellgring H

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Differential diagnosis between idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA) is often difficult in early disease stages. Since MSA is misdiagnosed as PD in more than 20% of the early stages, there is need for methods refining the differentiation of the two disease entities. In PD post...

journal_title：Journal of the neurological sciences

authors： Druschky A,Hilz MJ,Platsch G,Radespiel-Tröger M,Druschky K,Kuwert T,Neundörfer B

更新日期：2000-04-01 00:00:00

abstract：:The scalp distribution of the response to stimulation of the tibial nerve at the medial malleolus was systematically analysed. The somatosensory evoked potential (SEP) was recorded with electrodes placed in a transversal line over the ipsilateral and contralateral postcentral gyri and in a sagittal line over the longi...

journal_title：Journal of the neurological sciences

authors： Berić A,Prevec TS

更新日期：1983-05-01 00:00:00

abstract：:Recently, the beneficial role of minocycline on endogenous neurogenesis after cerebral ischemia has been contradicted by many reports. We examined whether minocycline influences post-ischemic neurogenesis in the subventricular zone. Adult male Sprague-Dawley rats were subjected to focal cerebral ischemia for 2 h, and ...

journal_title：Journal of the neurological sciences

authors： Kim BJ,Kim MJ,Park JM,Lee SH,Kim YJ,Ryu S,Kim YH,Yoon BW

更新日期：2009-04-15 00:00:00

abstract：:Respiratory failure accounts for the majority of deaths in amyotrophic lateral sclerosis (ALS) but only rarely is ALS diagnosed on the basis of respiratory insufficiency. We report four ALS patients presenting with acute respiratory failure. In three patients we have performed EMG needle examination of both hemidiaphr...

journal_title：Journal of the neurological sciences

authors： de Carvalho M,Matias T,Coelho F,Evangelista T,Pinto A,Luís ML

更新日期：1996-08-01 00:00:00

abstract：:Lipopolysaccharide (LPS) induces a strong immune response, and pretreatment with low dose of LPS suppresses the production of proinflammatory mediators. In the present study, we investigated the effect of LPS preconditioning on the delayed neuronal death in the gerbil hippocampal CA1 region after 5 min of transient ce...

journal_title：Journal of the neurological sciences

authors： Yu JT,Lee CH,Yoo KY,Choi JH,Li H,Park OK,Yan B,Hwang IK,Kwon YG,Kim YM,Won MH

更新日期：2010-09-15 00:00:00

abstract：:The neuropathological findings in two siblings with Menkes' disease were compared with representative material obtained from lambs suffering from swayback (enzootic ataxia). The aim of the study was to demonstrate the similarity of lesions in a genetic and a nutritional form of copper deficiency in support of the view...

journal_title：Journal of the neurological sciences

authors： Tan N,Urich H

更新日期：1983-12-01 00:00:00

abstract：:Polyglutamine (poly-Q) diseases are late-onset neurodegenerative disorders arising from the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract of glutamine residues. This kind of mutant proteins may be aggregated and accumulated, and thereby enhance cellular oxidative stress. In o...

journal_title：Journal of the neurological sciences

authors： Liu CS,Cheng WL,Kuo SJ,Li JY,Soong BW,Wei YH

更新日期：2008-01-15 00:00:00

abstract：PURPOSE:This study aimed to provide an updated overview of primary central lymphoma (PCL) using a large cohort of 33 years. That being said, we attempted to examine the patient demographics, management plans and their outcome, causes of death and the time trends in overall incidence and mortality rates of these patient...

journal_title：Journal of the neurological sciences

authors： Ghozy S,Dibas M,Afifi AM,Hashim MA,Abbas AS,Abdel-Daim MM,Phan K

更新日期：2020-08-15 00:00:00

abstract：:Primary progressive aphasia (PPA) is a group of disorders with progressive language impairment. Abnormal behaviour may develop in PPA as the disease evolves, but the clinical features and brain basis of behavioural change in PPA have not been fully defined. 33 PPA patients (9 semantic dementia, SD, 14 progressive nonf...

journal_title：Journal of the neurological sciences

authors： Rohrer JD,Warren JD

更新日期：2010-06-15 00:00:00

abstract：:In recent years it has become clear that multiple sclerosis (MS) patients benefit from physical exercise as performed in aerobic training but little is known about the effect on functional domains and physiological factors mediating these effects. We studied immunological, endocrine and neurotrophic factors as well as...

journal_title：Journal of the neurological sciences

authors： Schulz KH,Gold SM,Witte J,Bartsch K,Lang UE,Hellweg R,Reer R,Braumann KM,Heesen C

更新日期：2004-10-15 00:00:00

abstract：:We have investigated protein expression and genotype in 59 Becker muscular dystrophy (BMD) patients. The aim was to identify possible causes of the marked variability in phenotype in patients with similar deletions/mutations. The patients were examined neurologically and functionally and underwent Manual Muscle Testin...

journal_title：Journal of the neurological sciences

authors： Morandi L,Mora M,Confalonieri V,Barresi R,Di Blasi C,Brugnoni R,Bernasconi P,Mantegazza R,Dworzak F,Antozzi C

更新日期：1995-10-01 00:00:00

abstract：:Clinical and electrophysiological observations have been carried out on 12 patients with myotonic dystrophy. Neurological examination showed that the tendon reflexes were absent or weak in almost all cases, whereas the cutaneous reflexes were normal. Examination of both deep and superficial sensibility gave normal res...

journal_title：Journal of the neurological sciences

authors： Messina C,Tonali P,Scoppetta C

更新日期：1976-12-01 00:00:00

abstract：:Severe weakness of lower cranial and girdle muscles has been found in 4 subjects among 20 dialysis patients treated with carnitine in order to correct their high plasma triglyceride level. Neurophysiological investigation showed an impairment of neuromuscular transmission with short-term reduction of evoked muscle res...

journal_title：Journal of the neurological sciences

authors： De Grandis D,Mezzina C,Fiaschi A,Pinelli P,Bazzato G,Morachiello M

更新日期：1980-06-01 00:00:00

abstract：:The internodal length of remyelinated internodes was examined by observations on teased CNS nerve fibres following primary demyelination induced by intraspinal injections of lysolecithin into the white matter of cats. A remyelinated internode was identified as a thinly-myelinated internode, where a node of Ranvier was...

journal_title：Journal of the neurological sciences

authors： Blakemore WF,Murray JA

更新日期：1981-02-01 00:00:00

abstract：:Mutations in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1) have been reported in association with Charcot-Marie-Tooth disease type 2F or dHMN type II. We describe an Italian patient with wasting and weakness of distal muscles, involving primarily and mostly the lower limbs and later the upper limbs, in ...

journal_title：Journal of the neurological sciences

authors： Luigetti M,Fabrizi GM,Madia F,Ferrarini M,Conte A,Del Grande A,Tasca G,Tonali PA,Sabatelli M

更新日期：2010-11-15 00:00:00

abstract：OBJECTIVE:It has been suggested that autoantibodies may induce axonal damage in multiple sclerosis (MS). Optical coherence tomography (OCT) showed that thinning of peripapillary retinal nerve fiber layer (RNFL) and ganglion cell layer/inner plexiform (GCIPL) measurements reflect axonal loss in the disease. We investiga...

journal_title：Journal of the neurological sciences

authors： Álvarez-Cermeño JC,Muñoz-Negrete FJ,Costa-Frossard L,Sainz de la Maza S,Villar LM,Rebolleda G

更新日期：2016-01-15 00:00:00