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Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy.

Abstract：

:We report here the results of a simple and reproducible technique which can be used in semi-routine analysis of peripheral nerve biopsy specimens, so as to have a quantitative analysis of the major lipid classes, i.e. cholesterol, cerebrosides, ethanolamine phospholipids, phosphatidyl-choline, phosphatidyl-serine + phosphatidylinositol, sphingomyelin and gangliosides. Glycolipid hexoses, cholesterol and total phospholipids have been compared in different age groups. Although all lipid classes increased from the younger to the older age group, the molar ratio of cholesterol to phospholipid differed less than the glycolipid to phospholipid ratio. Both increased significantly, even between age group 10--16 and older patients (36, 54, 61, 68, 72 and 73 years old). Although individual variations in lipid content are noteworthy, it must be emphasized that evolution with age of the lipid composition must be taken into account. Furthermore, this study confirms and extends earlier findings of increased ganglioside levels in some cases of peripheral neuropathies observed during perhexiline maleate therapy where characteristic lipid-like polymorphous inclusions have been demonstrated.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Pollet S,Hauw JJ,Turpin JC,Le Saux F,Escourolle R,Baumann N

doi

10.1016/0022-510x(79)90039-x

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

199-206

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(79)90039-X

journal_volume

41

pub_type

杂志文章

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