Metronidazole-induced encephalopathy.


:We report the clinical, neuropsychological, and neuroimaging findings of two patients of diffuse encephalopathy associated with the use of metronidazole. Both patients showed characteristic abnormalities on magnetic resonance imaging (MRI) with diffusion weighted imaging (DWI) and recovered incompletely after the discontinuation of metronidazole. We also suggest that MRI with DWI may be useful in the diagnosis of metronidazole-induced encephalopathy, and that they have a role in the prediction of prognosis.


J Neurol Sci


Kim DW,Park JM,Yoon BW,Baek MJ,Kim JE,Kim S




Has Abstract


2004-09-15 00:00:00














  • Specificity of the clinical diagnosis of dementia.

    abstract::The specificity of anatomo-clinical observations were investigated on 776 out of 982 consecutive persons hospitalized at the University Psychiatric Clinic of Geneva. Discriminant function analysis shows that most of the anatomical classes (no dementia, senile dementia, Alzheimerized senile dementia and Alzheimer's pre...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Todorov AB,Go RC,Constantinidis J,Elston RC

    更新日期:1975-09-01 00:00:00

  • Selective type II fibre muscular atrophy in patients with osteoarthritis of the hip.

    abstract::The size and the distribution of type I and tye II fibres was determined in the gluteus maximus (21 cases), gluteus medius (56 cases) and tensor faciae latae (27 cases) muscles of patients with osteoarthritis of the hip. The patients were of both sexes, aged between 37 and 64 years (younger group) and between 65 and 7...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Sĭrca A,Susec-Michieli M

    更新日期:1980-01-01 00:00:00

  • Brainstem auditory evoked potential (BAEP) abnormalities in brucellosis.

    abstract::Twelve patients with neurobrucellosis and 17 patients with systemic brucellosis without neurological involvement underwent a brainstem auditory evoked potentials (BAEP) study. All neurobrucellosis patients (100%) showed abnormalities in their BAEP recordings, suggestive of brainstem lesions at various levels. On the o...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Khuraibet AJ,Shakir RA,Trontelj JV,Butinar D,al-Din AS

    更新日期:1988-11-01 00:00:00

  • Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.

    abstract::The purpose of this study was to compare magnetic resonance imaging (MRI) features and proton MR spectroscopy (1H-MRS) patterns of multiple sclerosis (MS) plaques in order to define the metabolic substrate in different lesion subtypes. Combined MRI and single-voxel 1H-MRS investigation was performed in 54 MS patients ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Simone IL,Tortorella C,Federico F,Liguori M,Lucivero V,Giannini P,Carrara D,Bellacosa A,Livrea P

    更新日期:2001-01-01 00:00:00

  • Postural control, falls and fear of falling in people with multiple sclerosis without mobility aids.

    abstract::The purpose of the study was to determine the relationship between static postural control parameters to fear of falling and falling history in people with multiple sclerosis (MS) without mobility assistive devices. One-hundred and seven relapsing-remitting patients diagnosed with MS, 62 women aged 42.8 (S.D.=12.0), p...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kalron A,Achiron A

    更新日期:2013-12-15 00:00:00

  • Panencephalitic Creutzfeldt-Jakob disease in a Chinese family. Unusual presentation with PrP codon 210 mutation and identification by PCR-SSCP.

    abstract::A point mutation at codon 210 (GTT to ATT) of the prion protein gene on chromosome 20 was found in a 48-year-old CJD-affected woman of a Chinese family. This affected woman had an early onset and long-duration form of CJD. Serial magnetic resonance image (MRI) analysis of this woman showed severe brain atrophy, promin...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Shyu WC,Hsu YD,Kao MC,Tsao WL

    更新日期:1996-11-01 00:00:00

  • Extraocular, limb and diaphragm muscle group-specific antioxidant enzyme activity patterns in control and mdx mice.

    abstract::The mechanisms primarily responsible for the degenerative processes occurring in dystrophic skeletal muscle remain unresolved. The identification of the mechanisms that lead to the complete sparing of extraocular muscle in dystrophinopathies is of particular interest. A number of studies have provided evidence to sugg...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Ragusa RJ,Chow CK,St Clair DK,Porter JD

    更新日期:1996-08-01 00:00:00

  • Clinical applications of quantitative sensory testing (QST).

    abstract::Quantitative sensory testing (QST) has been used clinically for the last two decades, yielding a substantial number of publications regarding these applications. In this review we tried to amass together the major findings of these publications into one monograph, excluding those dealing with pain. This was done with ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Zaslansky R,Yarnitsky D

    更新日期:1998-01-08 00:00:00

  • Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis.

    abstract::Predicting clinical outcome is one of the major and most interesting issues in MS patients. If the global evolution of disability (usually chosen levels on the Kurtzke's Disability Status Scale) has been widely studied, much less is known about the progression of disability during the secondary progressive phase of th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Vukusic S,Confavreux C

    更新日期:2003-02-15 00:00:00

  • Unusual neuro-ophthalmologic findings in a patient with anti-Yo-associated cerebellar degeneration.

    abstract::We report a woman with anti-Yo-associated cerebellar degeneration, severe eye movement abnormalities, and no evidence of malignancy after 3 years of extensive evaluation. The prominent neuro-ophthalmologic findings suggest brainstem involvement, which may be a novel manifestation of anti-Yo associated paraneoplastic s...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Cohen AB,Zupa-Fernandez A,Dalmau J,Galetta SL

    更新日期:2004-10-15 00:00:00

  • Galantamine inhibits beta-amyloid aggregation and cytotoxicity.

    abstract::The ability of galantamine (Reminyl) to inhibit the aggregation and toxicity of the beta-amyloid peptide (Abeta) was investigated. Galantamine showed concentration-dependent inhibition of aggregation of both Abeta 1-40 and Abeta 1-42, as determined by an ELISA method. Electron microscope studies of Abeta 1-40 incubate...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Matharu B,Gibson G,Parsons R,Huckerby TN,Moore SA,Cooper LJ,Millichamp R,Allsop D,Austen B

    更新日期:2009-05-15 00:00:00

  • The pattern of E2F1 and c-myb immunoreactivities in the CA1 region is different from those in the CA2/3 region of the gerbil hippocampus induced by transient ischemia.

    abstract::In this study, we examined transient ischemia-induced changes in transcription factor E2F1 and c-myb expressions in the gerbil hippocampus after 5 min of transient forebrain ischemia. E2F1 immunoreactivity significantly increased in the CA1 region 6-12 h after ischemia/reperfusion. c-myb immunoreactivity increased mai...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hwang IK,Yoo KY,Cho BM,Hwang HS,Kim SM,Oh SM,Choi SK,Hwang DY,Won MH,Moon SM

    更新日期:2006-09-25 00:00:00

  • Effect of arundic acid on serum S-100beta in ischemic stroke.

    abstract::We prospectively examined the effect of arundic acid (AA; ONO-2506) on S-100beta, an astrocyte-derived protein, in a phase I acute stroke study. Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days 1-7 and post-infus...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pettigrew LC,Kasner SE,Gorman M,Atkinson RP,Funakoshi Y,Ishibashi H,Arundic Acid (ONO-2506) Stroke Study Group.

    更新日期:2006-12-21 00:00:00

  • Effects of the rotigotine transdermal patch versus oral levodopa on swallowing in patients with Parkinson's disease.

    abstract:OBJECTIVES:Abnormal swallowing or dysphagia is a potentially fatal symptom in Parkinson's disease (PD) and is characterized by frequent silent aspiration, which is an unrecognized risk for aspiration pneumonia. While the effects of oral levodopa on swallowing functions remain controversial, several small-scale studies ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hirano M,Isono C,Fukuda K,Ueno S,Nakamura Y,Kusunoki S

    更新日期:2019-09-15 00:00:00

  • New spectrum of the neurologic consequences of Zika.

    abstract::Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barré Syndrome by an autoimmune response against peripheral myelin and/or axonal componen...

    journal_title:Journal of the neurological sciences

    pub_type: 社论


    authors: Medina MT,Medina-Montoya M

    更新日期:2017-12-15 00:00:00

  • Neurological aspects of eclampsia.

    abstract::Eclampsia accounts for a third of maternal mortality in developing countries. The neurological manifestations of eclampsia consist of seizures and alteration of sensorium or coma on a background of pre-eclampsia. Occasionally there can be focal neurological deficits too. Recent studies with CT scan and MRI have demons...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Thomas SV

    更新日期:1998-02-18 00:00:00

  • Quantitative changes during the postnatal maturation of the human visual cortex.

    abstract::Postnatal development of the human visual cortex is characterized by an overshooting growth pattern of its volume with a maximum at 8 postnatal months and by loss of a substantial proportion of its neurons. The highest rate of reduction in neuronal numbers is observed in layers II-IVa, with other layers showing a more...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Klekamp J,Riedel A,Harper C,Kretschmann HJ

    更新日期:1991-06-01 00:00:00

  • Sleep disordered breathing in facioscapulohumeral muscular dystrophy.

    abstract::Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent forms of muscular dystrophy. The aims of this study were: 1) to evaluate the prevalence of sleep disordered breathing (SDB) in patients with FSHD; 2) to define the sleep-related respiratory patterns in FSHD patients with SDB; and 3) to find the ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Della Marca G,Frusciante R,Dittoni S,Vollono C,Buccarella C,Iannaccone E,Rossi M,Scarano E,Pirronti T,Cianfoni A,Mazza S,Tonali PA,Ricci E

    更新日期:2009-10-15 00:00:00

  • Blink reflex in patients with hemispheric cerebrovascular accident (CVA). Blink reflex in CVA.

    abstract::A blink reflex consists of an early unilateral component, R1, and a late bilateral component, R2. During an acute phase of hemispheric cerebrovascular accident, R1 and R2 were abnormal in 30 and 50 of 66 patients, respectively. Paired stimuli usually corrected R1 but not R2, which was profoundly suppressed. The discre...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kimura J,Wilkinson JT,Damasio H,Adams HR Jr,Shivapour E,Yamada T

    更新日期:1985-01-01 00:00:00

  • Correlations of platelet-leukocyte aggregates with P-selectin S290N and P-selectin glycoprotein ligand-1 M62I genetic polymorphisms in patients with acute ischemic stroke.

    abstract:BACKGROUND:Platelet-leukocyte aggregations (PLA) play key roles in acute ischemic stroke (AIS) process and they are formed by the combination of P-selectin (SELP) expressed on the surface of the platelet membranes with P-selectin glycoprotein ligand-1(PSGL-1) expressed on the surface of the leukocytes. There are geneti...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Tao L,Changfu W,Linyun L,Bing M,Xiaohui H

    更新日期:2016-08-15 00:00:00

  • A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack.

    abstract::The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Chen L,Luo S,Yan L,Zhao W

    更新日期:2014-02-15 00:00:00

  • Immunologic derangement in myotonic dystrophy--abnormal contact sensitization to dinitrochlorobenzene.

    abstract::A broad spectrum of immunologic parameters was investigated in 13 cases of myotonic muscular dystrophy (MyD), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old woman having both MyD and a thymoma. This association between MyD and thymoma is probably coinciden...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kuroiwa Y,Sugita H,Toyokura Y,Mizoguchi M,Matsuo H,Nonaka Y

    更新日期:1980-08-01 00:00:00

  • Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in diffuse Lewy body disease.

    abstract::We performed a quantitative neuropathological investigation of senile plaques and neurofibrillary tangles in the brains of 14 Japanese patients with diffuse Lewy body disease (DLBD), and examined apolipoprotein E (APOE) gene polymorphism in these patients. Most DLBD brains had as many senile plaques as those with Alzh...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kawanishi C,Suzuki K,Odawara T,Iseki E,Onishi H,Miyakawa T,Yamada Y,Kosaka K,Kondo N,Yamamoto T

    更新日期:1996-03-01 00:00:00

  • Apolipoprotein E polymorphisms status in Iranian patients with multiple sclerosis.

    abstract:BACKGROUND:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system. Evidences linking apolipoprotein E (APOE) to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggest that it may be relevant in MS. The main goal of this study was to determine whet...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Rafiei M,Zarif Yeganeh M,Sheikholeslami S,Gozalpour E,Ghaffarpour M,Hedayati M

    更新日期:2012-09-15 00:00:00

  • An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study.

    abstract:OBJECTIVE:The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hindenes LB,Håberg AK,Mathiesen EB,Vangberg TR

    更新日期:2021-01-15 00:00:00

  • Occurrence of fatigue over 20 years after recovery from Guillain-Barré syndrome.

    abstract:INTRODUCTION:Reports regarding outcome of Guillain-Barré syndrome (GBS) are usually limited to relatively short follow-up. We assessed the occurrence of fatigue and correlated it to clinical measures in patients who had suffered from GBS over 20 years previously. METHODS:We contacted 24 patients with GBS requiring in-...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Drory VE,Bronipolsky T,Bluvshtein V,Catz A,Korczyn AD

    更新日期:2012-05-15 00:00:00

  • Characterization of multi-joint upper limb movements in a single task to assess bradykinesia.

    abstract::Bradykinesia is a disabling symptom of Parkinson's disease (PD) which presents with slowness of movement. Visual assessment using clinical rating scales is currently the gold standard to assess bradykinesia. Such assessments require multiple separate movements, are subjective, and rely on the ability of the rater to d...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Delrobaei M,Tran S,Gilmore G,McIsaac K,Jog M

    更新日期:2016-09-15 00:00:00

  • Normal muscle CPT1 and CPT2 activities in hepatic presentation patients with CPT1 deficiency in fibroblasts. Tissue specific isoforms of CPT1?

    abstract::Human carnitine palmitoyltransferase (CPT) deficiency results in 2 clinical forms: a more common "muscular form" with myoglobinuria with or without delayed or impaired ketogenesis and a rare "hepatic form" with hypoketotic hypoglycemia, encephalopathy and seizures without muscular manifestations. We present 2 patients...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Tein I,Demaugre F,Bonnefont JP,Saudubray JM

    更新日期:1989-09-01 00:00:00

  • Right proatlantal artery type I, right internal carotid occlusion, and left internal carotid stenosis: case report and review of the literature.

    abstract::A 66-year-old man presented with right cerebellar infarction and ischemic lesions in the left dorsal thalamus and right upper parietal lobe. Angiography showed occlusion of the right internal carotid artery proximal to an ipsilateral proatlantal artery type I, 70% stenosis of the left internal carotid artery, and apla...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Kolbinger R,Heindel W,Pawlik G,Erasmi-Körber H

    更新日期:1993-07-01 00:00:00

  • The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis.

    abstract::The process of vascularisation was studied in transplanted astrocytomas in BD-IX rats. The development of blood vessels was followed from the earliest signs of angiogenesis throughout tumour growth. On the basis of tumour vasculature, 3 consecutive stages of tumour growth could be distinguished; avascular, early vascu...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Deane BR,Lantos PL

    更新日期:1981-01-01 00:00:00